Differential regulation of gonadotropins and glycoprotein hormone alpha-subunit by IGF-I in anterior pituitary cells from male rats

IGF-I has been demonstrated to stimulate basal and GnRH-induced gonadotropin release. IGF-I also elicites alpha-subunit secretion in human pituitary tumor cells. The aims of this study were to evaluate both the effect of IGF-I on gonadotropin LH-beta and FSH-beta mRNA levels and glycoprotein alpha-s...

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Veröffentlicht in:	Journal of endocrinological investigation 2004-07, Vol.27 (7), p.670-675
Hauptverfasser:	Pazos, F, Sánchez-Franco, F, Balsa, J, Escalada, J, Cacicedo, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Culture Techniques Follicle Stimulating Hormone, beta Subunit - biosynthesis Gene Expression Regulation - drug effects Glycoprotein Hormones, alpha Subunit - biosynthesis Insulin-Like Growth Factor I - pharmacology Luteinizing Hormone, beta Subunit - biosynthesis Male Pituitary Gland - physiology Rats Rats, Wistar RNA, Messenger - analysis
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