Dicumarol, an inhibitor of ADP-ribosylation of CtBP3/BARS, fragments Golgi non-compact tubular zones and inhibits intra-Golgi transport

Dicumarol (3,3′-methylenebis[4-hydroxycoumarin]) is an inhibitor of brefeldin-A-dependent ADP-ribosylation that antagonises brefeldin-A-dependent Golgi tubulation and redistribution to the endoplasmic reticulum. We have investigated whether dicumarol can directly affect the morphology of the Golgi a...

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Veröffentlicht in:	European journal of cell biology 2004-07, Vol.83 (6), p.263-279
Hauptverfasser:	Mironov, Alexander A., Colanzi, Antonino, Polishchuk, Roman S., Beznoussenko, Galina V., Fusella, Aurora, Di Tullio, Giuseppe, Silletta, Maria Giuseppina, Corda, Daniela, De Matteis, Maria Antonietta, Luini, Alberto
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP-Ribosylation Factors - antagonists & inhibitors ADP-Ribosylation Factors - metabolism Animals Biological Transport - physiology Brefeldin A - metabolism Carrier Proteins - metabolism CHO Cells Coat Protein Complex I - metabolism Cricetinae Cricetulus dicumarol Dicumarol - pharmacology Endoplasmic Reticulum - ultrastructure Enzyme Inhibitors - pharmacology Golgi Golgi Apparatus - metabolism Golgi Apparatus - ultrastructure Microscopy, Electron, Transmission Rats Transcription Factors - metabolism transport tubules vesicles
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