Altered cortical visual processing in PD with hallucinations: An fMRI study
To compare fMRI activation during two visual stimulation paradigms in Parkinson disease (PD) subjects with chronic visual hallucinations vs PD patients who had never hallucinated. Twelve pairs of PD subjects, matched for age, PD duration, and dopaminergic drug exposure duration, participated in this...
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| Veröffentlicht in: | Neurology 2004-10, Vol.63 (8), p.1409-1416 |
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| creator | STEBBINS, G. T GOETZ, C. G CARRILLO, M. C BANGEN, K. J TURNER, D. A GLOVER, G. H GABRIELI, J. D. E |
| description | To compare fMRI activation during two visual stimulation paradigms in Parkinson disease (PD) subjects with chronic visual hallucinations vs PD patients who had never hallucinated.
Twelve pairs of PD subjects, matched for age, PD duration, and dopaminergic drug exposure duration, participated in this study. The authors examined group differences in activation during stroboscopic (flashing) vs no visual stimulation and kinematic (apparent motion) vs stationary visual stimulation.
During stroboscopic stimulation, non-hallucinating PD subjects showed significantly greater activation in the parietal lobe and cingulate gyrus compared to hallucinating PD subjects. In contrast, the hallucinating subjects showed significantly greater activation in the inferior frontal gyrus and the caudate nucleus. During kinematic stimulation, non-hallucinating PD subjects showed significantly greater activation in area V5/MT, parietal lobe, and cingulate gyrus compared to hallucinating PD subjects. Hallucinating PD subjects showed significantly greater activation in the superior frontal gyrus.
PD patients with chronic visual hallucinations respond to visual stimuli with greater frontal and subcortical activation and less visual cortical activation than non-hallucinating PD subjects. Shifting visual circuitry from posterior to anterior regions associated primarily with attention processes suggests altered network organization may play a role in the pathophysiology of visual hallucinations in PD. |
| doi_str_mv | 10.1212/01.WNL.0000141853.27081.BD |
| format | Article |
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Twelve pairs of PD subjects, matched for age, PD duration, and dopaminergic drug exposure duration, participated in this study. The authors examined group differences in activation during stroboscopic (flashing) vs no visual stimulation and kinematic (apparent motion) vs stationary visual stimulation.
During stroboscopic stimulation, non-hallucinating PD subjects showed significantly greater activation in the parietal lobe and cingulate gyrus compared to hallucinating PD subjects. In contrast, the hallucinating subjects showed significantly greater activation in the inferior frontal gyrus and the caudate nucleus. During kinematic stimulation, non-hallucinating PD subjects showed significantly greater activation in area V5/MT, parietal lobe, and cingulate gyrus compared to hallucinating PD subjects. Hallucinating PD subjects showed significantly greater activation in the superior frontal gyrus.
PD patients with chronic visual hallucinations respond to visual stimuli with greater frontal and subcortical activation and less visual cortical activation than non-hallucinating PD subjects. Shifting visual circuitry from posterior to anterior regions associated primarily with attention processes suggests altered network organization may play a role in the pathophysiology of visual hallucinations in PD.</description><identifier>ISSN: 0028-3878</identifier><identifier>EISSN: 1526-632X</identifier><identifier>DOI: 10.1212/01.WNL.0000141853.27081.BD</identifier><identifier>PMID: 15505157</identifier><identifier>CODEN: NEURAI</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Aged ; Attention - physiology ; Biological and medical sciences ; Case-Control Studies ; Caudate Nucleus - pathology ; Caudate Nucleus - physiopathology ; Cerebral Cortex - pathology ; Cerebral Cortex - physiopathology ; Chronic Disease ; Cohort Studies ; Dopamine Agents - therapeutic use ; Electrodiagnosis. Electric activity recording ; Frontal Lobe - pathology ; Frontal Lobe - physiopathology ; Gyrus Cinguli - pathology ; Gyrus Cinguli - physiopathology ; Hallucinations - diagnosis ; Hallucinations - etiology ; Hallucinations - physiopathology ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Imaging ; Medical sciences ; Nervous system ; Nervous system (semeiology, syndromes) ; Neurology ; Parietal Lobe - pathology ; Parietal Lobe - physiopathology ; Parkinson Disease - complications ; Photic Stimulation ; Visual Pathways - pathology ; Visual Pathways - physiopathology ; Visual Perception - physiology</subject><ispartof>Neurology, 2004-10, Vol.63 (8), p.1409-1416</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c345t-eb842b0d64fc79c87407e938b33dd8a7c6ca0277dbaa995aa18f27b82da1b213</citedby><cites>FETCH-LOGICAL-c345t-eb842b0d64fc79c87407e938b33dd8a7c6ca0277dbaa995aa18f27b82da1b213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16207015$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15505157$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>STEBBINS, G. T</creatorcontrib><creatorcontrib>GOETZ, C. G</creatorcontrib><creatorcontrib>CARRILLO, M. C</creatorcontrib><creatorcontrib>BANGEN, K. J</creatorcontrib><creatorcontrib>TURNER, D. A</creatorcontrib><creatorcontrib>GLOVER, G. H</creatorcontrib><creatorcontrib>GABRIELI, J. D. E</creatorcontrib><title>Altered cortical visual processing in PD with hallucinations: An fMRI study</title><title>Neurology</title><addtitle>Neurology</addtitle><description>To compare fMRI activation during two visual stimulation paradigms in Parkinson disease (PD) subjects with chronic visual hallucinations vs PD patients who had never hallucinated.
Twelve pairs of PD subjects, matched for age, PD duration, and dopaminergic drug exposure duration, participated in this study. The authors examined group differences in activation during stroboscopic (flashing) vs no visual stimulation and kinematic (apparent motion) vs stationary visual stimulation.
During stroboscopic stimulation, non-hallucinating PD subjects showed significantly greater activation in the parietal lobe and cingulate gyrus compared to hallucinating PD subjects. In contrast, the hallucinating subjects showed significantly greater activation in the inferior frontal gyrus and the caudate nucleus. During kinematic stimulation, non-hallucinating PD subjects showed significantly greater activation in area V5/MT, parietal lobe, and cingulate gyrus compared to hallucinating PD subjects. Hallucinating PD subjects showed significantly greater activation in the superior frontal gyrus.
PD patients with chronic visual hallucinations respond to visual stimuli with greater frontal and subcortical activation and less visual cortical activation than non-hallucinating PD subjects. Shifting visual circuitry from posterior to anterior regions associated primarily with attention processes suggests altered network organization may play a role in the pathophysiology of visual hallucinations in PD.</description><subject>Aged</subject><subject>Attention - physiology</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Caudate Nucleus - pathology</subject><subject>Caudate Nucleus - physiopathology</subject><subject>Cerebral Cortex - pathology</subject><subject>Cerebral Cortex - physiopathology</subject><subject>Chronic Disease</subject><subject>Cohort Studies</subject><subject>Dopamine Agents - therapeutic use</subject><subject>Electrodiagnosis. Electric activity recording</subject><subject>Frontal Lobe - pathology</subject><subject>Frontal Lobe - physiopathology</subject><subject>Gyrus Cinguli - pathology</subject><subject>Gyrus Cinguli - physiopathology</subject><subject>Hallucinations - diagnosis</subject><subject>Hallucinations - etiology</subject><subject>Hallucinations - physiopathology</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical sciences</subject><subject>Nervous system</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Parietal Lobe - pathology</subject><subject>Parietal Lobe - physiopathology</subject><subject>Parkinson Disease - complications</subject><subject>Photic Stimulation</subject><subject>Visual Pathways - pathology</subject><subject>Visual Pathways - physiopathology</subject><subject>Visual Perception - physiology</subject><issn>0028-3878</issn><issn>1526-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMlOwzAURS0EomX4BWQhwS7BQxw73XVgqCiDUCXYWY7jUKM0KXYC6t_j0kp9m7c59w0HgEuMYkwwuUE4fn-exSgUTrBgNCYcCRyPJgegjxlJo5SSj0PQR4iIiAoueuDE-6-AM8KzY9DDjCGGGe-Dx2HVGmcKqBvXWq0q-GN9F9rKNdp4b-tPaGv4OoG_tl3AhaqqTttatbap_QAOa1g-vU2hb7tifQaOSlV5c77rp2B-dzsfP0Szl_vpeDiLNE1YG5lcJCRHRZqUmmda8ARxk1GRU1oUQnGdaoUI50WuVJYxpbAoCc8FKRTOCaan4Ho7Npz43RnfyqX12lSVqk3TeZny8CfnWQAHW1C7xntnSrlydqncWmIkNyYlwjKYlHuT8t-kHE1C-GK3pcuXpthHd-oCcLUDlA_eSqdqbf2eSwnaHEL_AL5sfIE</recordid><startdate>20041026</startdate><enddate>20041026</enddate><creator>STEBBINS, G. T</creator><creator>GOETZ, C. G</creator><creator>CARRILLO, M. C</creator><creator>BANGEN, K. J</creator><creator>TURNER, D. A</creator><creator>GLOVER, G. H</creator><creator>GABRIELI, J. D. E</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20041026</creationdate><title>Altered cortical visual processing in PD with hallucinations: An fMRI study</title><author>STEBBINS, G. T ; GOETZ, C. G ; CARRILLO, M. C ; BANGEN, K. J ; TURNER, D. A ; GLOVER, G. H ; GABRIELI, J. D. E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c345t-eb842b0d64fc79c87407e938b33dd8a7c6ca0277dbaa995aa18f27b82da1b213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Aged</topic><topic>Attention - physiology</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Caudate Nucleus - pathology</topic><topic>Caudate Nucleus - physiopathology</topic><topic>Cerebral Cortex - pathology</topic><topic>Cerebral Cortex - physiopathology</topic><topic>Chronic Disease</topic><topic>Cohort Studies</topic><topic>Dopamine Agents - therapeutic use</topic><topic>Electrodiagnosis. Electric activity recording</topic><topic>Frontal Lobe - pathology</topic><topic>Frontal Lobe - physiopathology</topic><topic>Gyrus Cinguli - pathology</topic><topic>Gyrus Cinguli - physiopathology</topic><topic>Hallucinations - diagnosis</topic><topic>Hallucinations - etiology</topic><topic>Hallucinations - physiopathology</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical sciences</topic><topic>Nervous system</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Parietal Lobe - pathology</topic><topic>Parietal Lobe - physiopathology</topic><topic>Parkinson Disease - complications</topic><topic>Photic Stimulation</topic><topic>Visual Pathways - pathology</topic><topic>Visual Pathways - physiopathology</topic><topic>Visual Perception - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>STEBBINS, G. T</creatorcontrib><creatorcontrib>GOETZ, C. G</creatorcontrib><creatorcontrib>CARRILLO, M. C</creatorcontrib><creatorcontrib>BANGEN, K. J</creatorcontrib><creatorcontrib>TURNER, D. A</creatorcontrib><creatorcontrib>GLOVER, G. H</creatorcontrib><creatorcontrib>GABRIELI, J. D. E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>STEBBINS, G. T</au><au>GOETZ, C. G</au><au>CARRILLO, M. C</au><au>BANGEN, K. J</au><au>TURNER, D. A</au><au>GLOVER, G. H</au><au>GABRIELI, J. D. E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Altered cortical visual processing in PD with hallucinations: An fMRI study</atitle><jtitle>Neurology</jtitle><addtitle>Neurology</addtitle><date>2004-10-26</date><risdate>2004</risdate><volume>63</volume><issue>8</issue><spage>1409</spage><epage>1416</epage><pages>1409-1416</pages><issn>0028-3878</issn><eissn>1526-632X</eissn><coden>NEURAI</coden><abstract>To compare fMRI activation during two visual stimulation paradigms in Parkinson disease (PD) subjects with chronic visual hallucinations vs PD patients who had never hallucinated.
Twelve pairs of PD subjects, matched for age, PD duration, and dopaminergic drug exposure duration, participated in this study. The authors examined group differences in activation during stroboscopic (flashing) vs no visual stimulation and kinematic (apparent motion) vs stationary visual stimulation.
During stroboscopic stimulation, non-hallucinating PD subjects showed significantly greater activation in the parietal lobe and cingulate gyrus compared to hallucinating PD subjects. In contrast, the hallucinating subjects showed significantly greater activation in the inferior frontal gyrus and the caudate nucleus. During kinematic stimulation, non-hallucinating PD subjects showed significantly greater activation in area V5/MT, parietal lobe, and cingulate gyrus compared to hallucinating PD subjects. Hallucinating PD subjects showed significantly greater activation in the superior frontal gyrus.
PD patients with chronic visual hallucinations respond to visual stimuli with greater frontal and subcortical activation and less visual cortical activation than non-hallucinating PD subjects. Shifting visual circuitry from posterior to anterior regions associated primarily with attention processes suggests altered network organization may play a role in the pathophysiology of visual hallucinations in PD.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>15505157</pmid><doi>10.1212/01.WNL.0000141853.27081.BD</doi><tpages>8</tpages></addata></record> |
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| ispartof | Neurology, 2004-10, Vol.63 (8), p.1409-1416 |
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| subjects | Aged Attention - physiology Biological and medical sciences Case-Control Studies Caudate Nucleus - pathology Caudate Nucleus - physiopathology Cerebral Cortex - pathology Cerebral Cortex - physiopathology Chronic Disease Cohort Studies Dopamine Agents - therapeutic use Electrodiagnosis. Electric activity recording Frontal Lobe - pathology Frontal Lobe - physiopathology Gyrus Cinguli - pathology Gyrus Cinguli - physiopathology Hallucinations - diagnosis Hallucinations - etiology Hallucinations - physiopathology Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging Medical sciences Nervous system Nervous system (semeiology, syndromes) Neurology Parietal Lobe - pathology Parietal Lobe - physiopathology Parkinson Disease - complications Photic Stimulation Visual Pathways - pathology Visual Pathways - physiopathology Visual Perception - physiology |
| title | Altered cortical visual processing in PD with hallucinations: An fMRI study |
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