Clinical significance of isolated hippocampal volume asymmetry in childhood epilepsy
This study defines the clinical characteristics and evolution of 16 epileptic children with hippocampal asymmetry (HA) without sclerosis on MRI. The association of a positive family history of epilepsy (11/16), low incidence of febrile seizures (2/16), and benign prognosis (seizure control in monoth...
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| Veröffentlicht in: | Neurology 2004-10, Vol.63 (8), p.1503-1506 |
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| container_title | Neurology |
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| creator | MAJOR, P DECARIE, J.-C NADEAU, A DIADORI, P LORTIE, A NGUYEN, D COSSETTE, P CARMANT, L |
| description | This study defines the clinical characteristics and evolution of 16 epileptic children with hippocampal asymmetry (HA) without sclerosis on MRI. The association of a positive family history of epilepsy (11/16), low incidence of febrile seizures (2/16), and benign prognosis (seizure control in monotherapy in 11/16, mean follow-up = 4.3 years, range 1 to 10) suggest a different clinical presentation than patients with mesial temporal sclerosis. Genetic studies of these mostly French Canadian families should help confirm the existence of a distinct syndrome. |
| doi_str_mv | 10.1212/01.WNL.0000142079.79612.CB |
| format | Article |
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The association of a positive family history of epilepsy (11/16), low incidence of febrile seizures (2/16), and benign prognosis (seizure control in monotherapy in 11/16, mean follow-up = 4.3 years, range 1 to 10) suggest a different clinical presentation than patients with mesial temporal sclerosis. Genetic studies of these mostly French Canadian families should help confirm the existence of a distinct syndrome.</description><identifier>ISSN: 0028-3878</identifier><identifier>EISSN: 1526-632X</identifier><identifier>DOI: 10.1212/01.WNL.0000142079.79612.CB</identifier><identifier>PMID: 15505176</identifier><identifier>CODEN: NEURAI</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adolescent ; Age Factors ; Age of Onset ; Anticonvulsants - therapeutic use ; Atrophy - complications ; Atrophy - pathology ; Atrophy - physiopathology ; Biological and medical sciences ; Child ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Disease Progression ; Drug Resistance - genetics ; Epilepsy - diagnostic imaging ; Epilepsy - pathology ; Epilepsy - physiopathology ; Family Health ; Female ; Functional Laterality - physiology ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Hippocampus - diagnostic imaging ; Hippocampus - pathology ; Hippocampus - physiopathology ; Humans ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Nervous system (semeiology, syndromes) ; Neurology ; Predictive Value of Tests ; Prognosis ; Seizures, Febrile - epidemiology ; Tomography, X-Ray Computed</subject><ispartof>Neurology, 2004-10, Vol.63 (8), p.1503-1506</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c345t-8d881f5c2c60ef2b290fdc070730e1ac702a79fa9cde724344166dc8702000c3</citedby><cites>FETCH-LOGICAL-c345t-8d881f5c2c60ef2b290fdc070730e1ac702a79fa9cde724344166dc8702000c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16207034$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15505176$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MAJOR, P</creatorcontrib><creatorcontrib>DECARIE, J.-C</creatorcontrib><creatorcontrib>NADEAU, A</creatorcontrib><creatorcontrib>DIADORI, P</creatorcontrib><creatorcontrib>LORTIE, A</creatorcontrib><creatorcontrib>NGUYEN, D</creatorcontrib><creatorcontrib>COSSETTE, P</creatorcontrib><creatorcontrib>CARMANT, L</creatorcontrib><title>Clinical significance of isolated hippocampal volume asymmetry in childhood epilepsy</title><title>Neurology</title><addtitle>Neurology</addtitle><description>This study defines the clinical characteristics and evolution of 16 epileptic children with hippocampal asymmetry (HA) without sclerosis on MRI. The association of a positive family history of epilepsy (11/16), low incidence of febrile seizures (2/16), and benign prognosis (seizure control in monotherapy in 11/16, mean follow-up = 4.3 years, range 1 to 10) suggest a different clinical presentation than patients with mesial temporal sclerosis. Genetic studies of these mostly French Canadian families should help confirm the existence of a distinct syndrome.</description><subject>Adolescent</subject><subject>Age Factors</subject><subject>Age of Onset</subject><subject>Anticonvulsants - therapeutic use</subject><subject>Atrophy - complications</subject><subject>Atrophy - pathology</subject><subject>Atrophy - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Disease Progression</subject><subject>Drug Resistance - genetics</subject><subject>Epilepsy - diagnostic imaging</subject><subject>Epilepsy - pathology</subject><subject>Epilepsy - physiopathology</subject><subject>Family Health</subject><subject>Female</subject><subject>Functional Laterality - physiology</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Hippocampus - diagnostic imaging</subject><subject>Hippocampus - pathology</subject><subject>Hippocampus - physiopathology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Seizures, Febrile - epidemiology</subject><subject>Tomography, X-Ray Computed</subject><issn>0028-3878</issn><issn>1526-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLxDAQgIMo7rr6F6QIemvNo01ab27xBYteFvQWsnm4kbSpTSv03xvdhZ3LDMM3M8wHwBWCGcII30KUvb-uMhgD5RiyKmMVRTirl0dgjgpMU0rwxzGYQ4jLlJSsnIGzEL4iXmBWnYIZKgpYIEbnYF0721opXBLsZ2tNLFupE28SG7wTg1bJ1nadl6LpIvTj3djoRISpafTQT4ltE7m1Tm29V4nurNNdmM7BiREu6It9XoD148O6fk5Xb08v9f0qlSQvhrRUZYlMIbGkUBu8wRU0SkIGGYEaCckgFqwyopJKM5yTPEeUKlnGfnxdkgW42a3tev896jDwxgapnROt9mPglMWHY0TwbgfK3ofQa8O73jainziC_E8ph4hHpfyglP8r5fUyDl_ur4ybRqvD6N5hBK73gAhRpOmjQRsOHI37IMnJLwr7gHU</recordid><startdate>20041026</startdate><enddate>20041026</enddate><creator>MAJOR, P</creator><creator>DECARIE, J.-C</creator><creator>NADEAU, A</creator><creator>DIADORI, P</creator><creator>LORTIE, A</creator><creator>NGUYEN, D</creator><creator>COSSETTE, P</creator><creator>CARMANT, L</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20041026</creationdate><title>Clinical significance of isolated hippocampal volume asymmetry in childhood epilepsy</title><author>MAJOR, P ; DECARIE, J.-C ; NADEAU, A ; DIADORI, P ; LORTIE, A ; NGUYEN, D ; COSSETTE, P ; CARMANT, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c345t-8d881f5c2c60ef2b290fdc070730e1ac702a79fa9cde724344166dc8702000c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adolescent</topic><topic>Age Factors</topic><topic>Age of Onset</topic><topic>Anticonvulsants - therapeutic use</topic><topic>Atrophy - complications</topic><topic>Atrophy - pathology</topic><topic>Atrophy - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Disease Progression</topic><topic>Drug Resistance - genetics</topic><topic>Epilepsy - diagnostic imaging</topic><topic>Epilepsy - pathology</topic><topic>Epilepsy - physiopathology</topic><topic>Family Health</topic><topic>Female</topic><topic>Functional Laterality - physiology</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Hippocampus - diagnostic imaging</topic><topic>Hippocampus - pathology</topic><topic>Hippocampus - physiopathology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Seizures, Febrile - epidemiology</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MAJOR, P</creatorcontrib><creatorcontrib>DECARIE, J.-C</creatorcontrib><creatorcontrib>NADEAU, A</creatorcontrib><creatorcontrib>DIADORI, P</creatorcontrib><creatorcontrib>LORTIE, A</creatorcontrib><creatorcontrib>NGUYEN, D</creatorcontrib><creatorcontrib>COSSETTE, P</creatorcontrib><creatorcontrib>CARMANT, L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MAJOR, P</au><au>DECARIE, J.-C</au><au>NADEAU, A</au><au>DIADORI, P</au><au>LORTIE, A</au><au>NGUYEN, D</au><au>COSSETTE, P</au><au>CARMANT, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical significance of isolated hippocampal volume asymmetry in childhood epilepsy</atitle><jtitle>Neurology</jtitle><addtitle>Neurology</addtitle><date>2004-10-26</date><risdate>2004</risdate><volume>63</volume><issue>8</issue><spage>1503</spage><epage>1506</epage><pages>1503-1506</pages><issn>0028-3878</issn><eissn>1526-632X</eissn><coden>NEURAI</coden><abstract>This study defines the clinical characteristics and evolution of 16 epileptic children with hippocampal asymmetry (HA) without sclerosis on MRI. The association of a positive family history of epilepsy (11/16), low incidence of febrile seizures (2/16), and benign prognosis (seizure control in monotherapy in 11/16, mean follow-up = 4.3 years, range 1 to 10) suggest a different clinical presentation than patients with mesial temporal sclerosis. Genetic studies of these mostly French Canadian families should help confirm the existence of a distinct syndrome.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>15505176</pmid><doi>10.1212/01.WNL.0000142079.79612.CB</doi><tpages>4</tpages></addata></record> |
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| ispartof | Neurology, 2004-10, Vol.63 (8), p.1503-1506 |
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| source | MEDLINE; Journals@Ovid Complete; Alma/SFX Local Collection |
| subjects | Adolescent Age Factors Age of Onset Anticonvulsants - therapeutic use Atrophy - complications Atrophy - pathology Atrophy - physiopathology Biological and medical sciences Child Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Progression Drug Resistance - genetics Epilepsy - diagnostic imaging Epilepsy - pathology Epilepsy - physiopathology Family Health Female Functional Laterality - physiology Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Hippocampus - diagnostic imaging Hippocampus - pathology Hippocampus - physiopathology Humans Magnetic Resonance Imaging Male Medical sciences Nervous system (semeiology, syndromes) Neurology Predictive Value of Tests Prognosis Seizures, Febrile - epidemiology Tomography, X-Ray Computed |
| title | Clinical significance of isolated hippocampal volume asymmetry in childhood epilepsy |
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