Intestinal mucosal mast cell immune response and pathogenesis of two Eimeria acervulina isolates in broiler chickens
Four experiments were conducted comparing intestinal immune responses to 2 isolates of Eimeria acervulina (EA), EA1 and EA2. In experiments 1 and 2, broiler chicks of 2 commercial breeds were divided into control (nonchallenged), EA1-, or EA2-challenged groups. On d 6 postchallenge (PC), changes in...
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| Veröffentlicht in: | Poultry science 2004-10, Vol.83 (10), p.1667-1674 |
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| creator | Morris, B.C Danforth, H.D Caldwell, D.J Pierson, F.W McElroy, A.P |
| description | Four experiments were conducted comparing intestinal immune responses to 2 isolates of Eimeria acervulina (EA), EA1 and EA2. In experiments 1 and 2, broiler chicks of 2 commercial breeds were divided into control (nonchallenged), EA1-, or EA2-challenged groups. On d 6 postchallenge (PC), changes in BW were determined, intestinal lesions were scored, and duodenal tissue was evaluated for morphometric alterations and mucosal mast cell numbers. EA1 produced classical duodenal lesions and reduced villus height to crypt depth ratios compared with controls; however, no differences were found in mast cell counts. EA2 produced different results, and observed data were suggestive of an anaphylactic-like intestinal secretory response compared with EA1 or controls. In experiment 3, tissues were analyzed from d 2 through 6 PC. Villus atrophy and crypt hyperplasia were increased on d 5 PC in both challenged groups. Mast cell counts were significantly greater on d 3 and 4 PC in EA1-challenged birds. In experiment 4, EA2 oocysts were cleaned with 5.25% sodium hypochlorite to evaluate the possibility of a bacterial contaminant contributing to the pathogenesis of intestinal alterations. No evidence of a bacterial contaminant contributing to the pathology was observed. These data are indicative of differential host response and immunovariability between different isolates of the same Eimeria species in 2 breeds of commercial broiler chickens. |
| doi_str_mv | 10.1093/ps/83.10.1667 |
| format | Article |
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In experiments 1 and 2, broiler chicks of 2 commercial breeds were divided into control (nonchallenged), EA1-, or EA2-challenged groups. On d 6 postchallenge (PC), changes in BW were determined, intestinal lesions were scored, and duodenal tissue was evaluated for morphometric alterations and mucosal mast cell numbers. EA1 produced classical duodenal lesions and reduced villus height to crypt depth ratios compared with controls; however, no differences were found in mast cell counts. EA2 produced different results, and observed data were suggestive of an anaphylactic-like intestinal secretory response compared with EA1 or controls. In experiment 3, tissues were analyzed from d 2 through 6 PC. Villus atrophy and crypt hyperplasia were increased on d 5 PC in both challenged groups. Mast cell counts were significantly greater on d 3 and 4 PC in EA1-challenged birds. In experiment 4, EA2 oocysts were cleaned with 5.25% sodium hypochlorite to evaluate the possibility of a bacterial contaminant contributing to the pathogenesis of intestinal alterations. No evidence of a bacterial contaminant contributing to the pathology was observed. These data are indicative of differential host response and immunovariability between different isolates of the same Eimeria species in 2 breeds of commercial broiler chickens.</description><identifier>ISSN: 0032-5791</identifier><identifier>EISSN: 1525-3171</identifier><identifier>DOI: 10.1093/ps/83.10.1667</identifier><identifier>PMID: 15510551</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Animals ; body weight ; broiler chickens ; Chickens - immunology ; Coccidiosis - immunology ; Coccidiosis - veterinary ; Eimeria - immunology ; Eimeria - pathogenicity ; Immunity, Mucosal - immunology ; intestinal mucosa ; Intestinal Mucosa - immunology ; Mast Cells - immunology ; Poultry Diseases - immunology ; strain differences ; villi</subject><ispartof>Poultry science, 2004-10, Vol.83 (10), p.1667-1674</ispartof><rights>Copyright Poultry Science Association Oct 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-d4ed7a9d964268ec319761faa32a0e156a3f5d43a44bba30c469f80a449b11b3</citedby><cites>FETCH-LOGICAL-c381t-d4ed7a9d964268ec319761faa32a0e156a3f5d43a44bba30c469f80a449b11b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15510551$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morris, B.C</creatorcontrib><creatorcontrib>Danforth, H.D</creatorcontrib><creatorcontrib>Caldwell, D.J</creatorcontrib><creatorcontrib>Pierson, F.W</creatorcontrib><creatorcontrib>McElroy, A.P</creatorcontrib><title>Intestinal mucosal mast cell immune response and pathogenesis of two Eimeria acervulina isolates in broiler chickens</title><title>Poultry science</title><addtitle>Poult Sci</addtitle><description>Four experiments were conducted comparing intestinal immune responses to 2 isolates of Eimeria acervulina (EA), EA1 and EA2. In experiments 1 and 2, broiler chicks of 2 commercial breeds were divided into control (nonchallenged), EA1-, or EA2-challenged groups. On d 6 postchallenge (PC), changes in BW were determined, intestinal lesions were scored, and duodenal tissue was evaluated for morphometric alterations and mucosal mast cell numbers. EA1 produced classical duodenal lesions and reduced villus height to crypt depth ratios compared with controls; however, no differences were found in mast cell counts. EA2 produced different results, and observed data were suggestive of an anaphylactic-like intestinal secretory response compared with EA1 or controls. In experiment 3, tissues were analyzed from d 2 through 6 PC. Villus atrophy and crypt hyperplasia were increased on d 5 PC in both challenged groups. Mast cell counts were significantly greater on d 3 and 4 PC in EA1-challenged birds. In experiment 4, EA2 oocysts were cleaned with 5.25% sodium hypochlorite to evaluate the possibility of a bacterial contaminant contributing to the pathogenesis of intestinal alterations. No evidence of a bacterial contaminant contributing to the pathology was observed. These data are indicative of differential host response and immunovariability between different isolates of the same Eimeria species in 2 breeds of commercial broiler chickens.</description><subject>Animals</subject><subject>body weight</subject><subject>broiler chickens</subject><subject>Chickens - immunology</subject><subject>Coccidiosis - immunology</subject><subject>Coccidiosis - veterinary</subject><subject>Eimeria - immunology</subject><subject>Eimeria - pathogenicity</subject><subject>Immunity, Mucosal - immunology</subject><subject>intestinal mucosa</subject><subject>Intestinal Mucosa - immunology</subject><subject>Mast Cells - immunology</subject><subject>Poultry Diseases - immunology</subject><subject>strain differences</subject><subject>villi</subject><issn>0032-5791</issn><issn>1525-3171</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkUGL1TAUhYMoznN06VaDC3edSXqbtFnKMOrAgAvHdbhN05mMbVJzW8V_b-p7ILi4HA58HDjnMvZaigspDFwudNnBxe60bp-wg1S1qkC28ik7CAF1pVojz9gLokch6h16zs6kUlKUO7D1Jq6e1hBx4vPmEu2KtHLnp4mHed6i59nTkiJ5jnHgC64P6d5HT4F4Gvn6K_HrMPsckKPz-ec2lTQeKE1YonmIvM8pTD5z9xDcdx_pJXs24kT-1UnP2d3H67urz9Xtl083Vx9uKwedXKuh8UOLZjC6qXXnHUjTajkiQo3CS6URRjU0gE3T9wjCNdqMnSjW9FL2cM7eH2OXnH5spaWdA-29MPq0kdWtKGtpKOC7_8DHtOUyCdm6Bqk60ZkCVUfI5USU_WiXHGbMv60Udn-FXch28NeVlQv_5hS69bMf_tGn7Qvw9giMmCze50D229daSBDCKAXQwB9HZ48B</recordid><startdate>20041001</startdate><enddate>20041001</enddate><creator>Morris, B.C</creator><creator>Danforth, H.D</creator><creator>Caldwell, D.J</creator><creator>Pierson, F.W</creator><creator>McElroy, A.P</creator><general>Oxford University Press</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L6V</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7S</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20041001</creationdate><title>Intestinal mucosal mast cell immune response and pathogenesis of two Eimeria acervulina isolates in broiler chickens</title><author>Morris, B.C ; Danforth, H.D ; Caldwell, D.J ; Pierson, F.W ; McElroy, A.P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-d4ed7a9d964268ec319761faa32a0e156a3f5d43a44bba30c469f80a449b11b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>body weight</topic><topic>broiler chickens</topic><topic>Chickens - immunology</topic><topic>Coccidiosis - immunology</topic><topic>Coccidiosis - veterinary</topic><topic>Eimeria - immunology</topic><topic>Eimeria - pathogenicity</topic><topic>Immunity, Mucosal - immunology</topic><topic>intestinal mucosa</topic><topic>Intestinal Mucosa - immunology</topic><topic>Mast Cells - immunology</topic><topic>Poultry Diseases - immunology</topic><topic>strain differences</topic><topic>villi</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morris, B.C</creatorcontrib><creatorcontrib>Danforth, H.D</creatorcontrib><creatorcontrib>Caldwell, D.J</creatorcontrib><creatorcontrib>Pierson, F.W</creatorcontrib><creatorcontrib>McElroy, A.P</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Engineering Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Engineering Database</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Poultry science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morris, B.C</au><au>Danforth, H.D</au><au>Caldwell, D.J</au><au>Pierson, F.W</au><au>McElroy, A.P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intestinal mucosal mast cell immune response and pathogenesis of two Eimeria acervulina isolates in broiler chickens</atitle><jtitle>Poultry science</jtitle><addtitle>Poult Sci</addtitle><date>2004-10-01</date><risdate>2004</risdate><volume>83</volume><issue>10</issue><spage>1667</spage><epage>1674</epage><pages>1667-1674</pages><issn>0032-5791</issn><eissn>1525-3171</eissn><abstract>Four experiments were conducted comparing intestinal immune responses to 2 isolates of Eimeria acervulina (EA), EA1 and EA2. In experiments 1 and 2, broiler chicks of 2 commercial breeds were divided into control (nonchallenged), EA1-, or EA2-challenged groups. On d 6 postchallenge (PC), changes in BW were determined, intestinal lesions were scored, and duodenal tissue was evaluated for morphometric alterations and mucosal mast cell numbers. EA1 produced classical duodenal lesions and reduced villus height to crypt depth ratios compared with controls; however, no differences were found in mast cell counts. EA2 produced different results, and observed data were suggestive of an anaphylactic-like intestinal secretory response compared with EA1 or controls. In experiment 3, tissues were analyzed from d 2 through 6 PC. Villus atrophy and crypt hyperplasia were increased on d 5 PC in both challenged groups. Mast cell counts were significantly greater on d 3 and 4 PC in EA1-challenged birds. In experiment 4, EA2 oocysts were cleaned with 5.25% sodium hypochlorite to evaluate the possibility of a bacterial contaminant contributing to the pathogenesis of intestinal alterations. No evidence of a bacterial contaminant contributing to the pathology was observed. These data are indicative of differential host response and immunovariability between different isolates of the same Eimeria species in 2 breeds of commercial broiler chickens.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>15510551</pmid><doi>10.1093/ps/83.10.1667</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Poultry science, 2004-10, Vol.83 (10), p.1667-1674 |
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| subjects | Animals body weight broiler chickens Chickens - immunology Coccidiosis - immunology Coccidiosis - veterinary Eimeria - immunology Eimeria - pathogenicity Immunity, Mucosal - immunology intestinal mucosa Intestinal Mucosa - immunology Mast Cells - immunology Poultry Diseases - immunology strain differences villi |
| title | Intestinal mucosal mast cell immune response and pathogenesis of two Eimeria acervulina isolates in broiler chickens |
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