Role of neutralizing antibodies in PRRSV protective immunity
Little has been known about the components of the immune system that are effective in the protection of a pig against PRRSV infection. Although antibodies were initially perceived as a deleterious, ineffective component of the PRRSV-specific immune response, neutralizing antibodies (NA) are now cons...
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| Veröffentlicht in: | Veterinary immunology and immunopathology 2004-12, Vol.102 (3), p.155-163 |
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| container_title | Veterinary immunology and immunopathology |
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| creator | Lopez, O.J. Osorio, F.A. |
| description | Little has been known about the components of the immune system that are effective in the protection of a pig against PRRSV infection. Although antibodies were initially perceived as a deleterious, ineffective component of the PRRSV-specific immune response, neutralizing antibodies (NA) are now considered to be an important correlate of protective immunity against PRRSV. This paper reviews the current knowledge on arterivirus-specific NA, the role that NA have in protection against infection with PRRSV, as well as the viral molecular structures that are responsible for the production of this type of antibodies by the pig. This information should prove central to the design of new generation vaccines against PRRSV. |
| doi_str_mv | 10.1016/j.vetimm.2004.09.005 |
| format | Article |
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Although antibodies were initially perceived as a deleterious, ineffective component of the PRRSV-specific immune response, neutralizing antibodies (NA) are now considered to be an important correlate of protective immunity against PRRSV. This paper reviews the current knowledge on arterivirus-specific NA, the role that NA have in protection against infection with PRRSV, as well as the viral molecular structures that are responsible for the production of this type of antibodies by the pig. This information should prove central to the design of new generation vaccines against PRRSV.</description><identifier>ISSN: 0165-2427</identifier><identifier>EISSN: 1873-2534</identifier><identifier>DOI: 10.1016/j.vetimm.2004.09.005</identifier><identifier>PMID: 15507302</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; antibodies ; Antibodies, Viral - biosynthesis ; Antibodies, Viral - immunology ; disease course ; immune response ; immunity ; literature reviews ; Models, Immunological ; neutralizing antibodies ; porcine reproductive and respiratory syndrome ; Porcine Reproductive and Respiratory Syndrome - immunology ; Porcine Reproductive and Respiratory Syndrome - prevention & control ; Porcine Reproductive and Respiratory Syndrome - virology ; Porcine reproductive and respiratory syndrome virus ; Porcine respiratory and reproductive syndrome virus ; Porcine respiratory and reproductive syndrome virus - immunology ; swine ; Swine - immunology ; Swine - virology ; viral antigens ; viral proteins ; Viral Vaccines - immunology</subject><ispartof>Veterinary immunology and immunopathology, 2004-12, Vol.102 (3), p.155-163</ispartof><rights>2004 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-d55e428bd370b5de78d90e604570ec699b3883e83d57b395c3297deaa3e1835c3</citedby><cites>FETCH-LOGICAL-c479t-d55e428bd370b5de78d90e604570ec699b3883e83d57b395c3297deaa3e1835c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165242704002363$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15507302$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lopez, O.J.</creatorcontrib><creatorcontrib>Osorio, F.A.</creatorcontrib><title>Role of neutralizing antibodies in PRRSV protective immunity</title><title>Veterinary immunology and immunopathology</title><addtitle>Vet Immunol Immunopathol</addtitle><description>Little has been known about the components of the immune system that are effective in the protection of a pig against PRRSV infection. 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This information should prove central to the design of new generation vaccines against PRRSV.</description><subject>Animals</subject><subject>antibodies</subject><subject>Antibodies, Viral - biosynthesis</subject><subject>Antibodies, Viral - immunology</subject><subject>disease course</subject><subject>immune response</subject><subject>immunity</subject><subject>literature reviews</subject><subject>Models, Immunological</subject><subject>neutralizing antibodies</subject><subject>porcine reproductive and respiratory syndrome</subject><subject>Porcine Reproductive and Respiratory Syndrome - immunology</subject><subject>Porcine Reproductive and Respiratory Syndrome - prevention & control</subject><subject>Porcine Reproductive and Respiratory Syndrome - virology</subject><subject>Porcine reproductive and respiratory syndrome virus</subject><subject>Porcine respiratory and reproductive syndrome virus</subject><subject>Porcine respiratory and reproductive syndrome virus - immunology</subject><subject>swine</subject><subject>Swine - immunology</subject><subject>Swine - virology</subject><subject>viral antigens</subject><subject>viral proteins</subject><subject>Viral Vaccines - immunology</subject><issn>0165-2427</issn><issn>1873-2534</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQhkVJaLab_oPS-NSbnZFlWRKEQAlpGgi07GZ7FbI1Dlr8sZHsheTXR4sXcktPw8Az78w8hHyjkFGg5eU22-Poui7LAYoMVAbAP5EFlYKlOWfFCVlEjKd5kYsz8iWELURCSfmZnFHOQTDIF-RqNbSYDE3S4zR607pX1z8lph9dNViHIXF98ne1Wv9Ldn4YsR7dHpO4derd-HJOThvTBvx6rEuy-XX7ePM7ffhzd3_z8yGtC6HG1HKORS4rywRU3KKQVgGWUHABWJdKVUxKhpJZLiqmeM1yJSwaw5BKFtsl-THnxhueJwyj7lyosW1Nj8MUdCmAckrZf0EqRKlkKSNYzGDthxA8NnrnXWf8i6agD3r1Vs969UGvBqWjvDj2_Zg_VR3a96GjzwhczEBjBm2evAt6s86BMgAVH1WHiOuZwChs79DrUDvsa7TOR73aDu7jG94A8QWV2w</recordid><startdate>20041208</startdate><enddate>20041208</enddate><creator>Lopez, O.J.</creator><creator>Osorio, F.A.</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20041208</creationdate><title>Role of neutralizing antibodies in PRRSV protective immunity</title><author>Lopez, O.J. ; Osorio, F.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-d55e428bd370b5de78d90e604570ec699b3883e83d57b395c3297deaa3e1835c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>antibodies</topic><topic>Antibodies, Viral - biosynthesis</topic><topic>Antibodies, Viral - immunology</topic><topic>disease course</topic><topic>immune response</topic><topic>immunity</topic><topic>literature reviews</topic><topic>Models, Immunological</topic><topic>neutralizing antibodies</topic><topic>porcine reproductive and respiratory syndrome</topic><topic>Porcine Reproductive and Respiratory Syndrome - immunology</topic><topic>Porcine Reproductive and Respiratory Syndrome - prevention & control</topic><topic>Porcine Reproductive and Respiratory Syndrome - virology</topic><topic>Porcine reproductive and respiratory syndrome virus</topic><topic>Porcine respiratory and reproductive syndrome virus</topic><topic>Porcine respiratory and reproductive syndrome virus - immunology</topic><topic>swine</topic><topic>Swine - immunology</topic><topic>Swine - virology</topic><topic>viral antigens</topic><topic>viral proteins</topic><topic>Viral Vaccines - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lopez, O.J.</creatorcontrib><creatorcontrib>Osorio, F.A.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary immunology and immunopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lopez, O.J.</au><au>Osorio, F.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of neutralizing antibodies in PRRSV protective immunity</atitle><jtitle>Veterinary immunology and immunopathology</jtitle><addtitle>Vet Immunol Immunopathol</addtitle><date>2004-12-08</date><risdate>2004</risdate><volume>102</volume><issue>3</issue><spage>155</spage><epage>163</epage><pages>155-163</pages><issn>0165-2427</issn><eissn>1873-2534</eissn><abstract>Little has been known about the components of the immune system that are effective in the protection of a pig against PRRSV infection. Although antibodies were initially perceived as a deleterious, ineffective component of the PRRSV-specific immune response, neutralizing antibodies (NA) are now considered to be an important correlate of protective immunity against PRRSV. This paper reviews the current knowledge on arterivirus-specific NA, the role that NA have in protection against infection with PRRSV, as well as the viral molecular structures that are responsible for the production of this type of antibodies by the pig. This information should prove central to the design of new generation vaccines against PRRSV.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>15507302</pmid><doi>10.1016/j.vetimm.2004.09.005</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0165-2427 |
| ispartof | Veterinary immunology and immunopathology, 2004-12, Vol.102 (3), p.155-163 |
| issn | 0165-2427 1873-2534 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals antibodies Antibodies, Viral - biosynthesis Antibodies, Viral - immunology disease course immune response immunity literature reviews Models, Immunological neutralizing antibodies porcine reproductive and respiratory syndrome Porcine Reproductive and Respiratory Syndrome - immunology Porcine Reproductive and Respiratory Syndrome - prevention & control Porcine Reproductive and Respiratory Syndrome - virology Porcine reproductive and respiratory syndrome virus Porcine respiratory and reproductive syndrome virus Porcine respiratory and reproductive syndrome virus - immunology swine Swine - immunology Swine - virology viral antigens viral proteins Viral Vaccines - immunology |
| title | Role of neutralizing antibodies in PRRSV protective immunity |
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