High-resolution differentiation of transmissible spongiform encephalopathy strains by quantitative N-terminal amino acid profiling (N-TAAP) of PK-digested abnormal prion protein

New forms of transmissible spongiform encephalopathy (TSE) continue to be identified, and consequently sensitive differential diagnosis is increasingly important both for the management of disease in humans and livestock and in providing confidence in the safety of the food chain. TSE diseases are a...

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Veröffentlicht in:	Journal of mass spectrometry. 2009-03, Vol.44 (3), p.384-396
Hauptverfasser:	Gielbert, Adriana, Davis, Linda A, Sayers, A. Robin, Hope, James, Gill, Andrew C, Sauer, Maurice J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animal productions Animals Biological and medical sciences Biomarkers - chemistry Biomarkers - metabolism Brain Chemistry Cattle Chromatography, Liquid Diagnosis, Differential Encephalopathy, Bovine Spongiform - classification Encephalopathy, Bovine Spongiform - diagnosis Endopeptidase K - metabolism Fundamental and applied biological sciences. Psychology Molecular Sequence Data peptide fragmentation Peptide Fragments - chemistry Peptide Fragments - metabolism peptide quantification Prion Diseases - classification Prion Diseases - diagnosis prion protein prion structure PrPSc Proteins - chemistry PrPSc Proteins - metabolism Scrapie - classification Scrapie - diagnosis selected reaction monitoring Sequence Analysis, Protein - methods Sheep Sheep Diseases - classification Sheep Diseases - diagnosis strain differentiation Tandem Mass Spectrometry Terrestrial animal productions transmissible spongiform encephalopathy Vertebrates
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