Studies on antibacterial, antioxidant and fibroblast growth stimulation of wound healing remedies from South Africa
Aqueous and methanol extracts of Urtica urens, Capparis tomentosa, Dicoma anomala, Leonotis leonorus, Xysmalobium undulatum, Helichrysum foetidum, Pterocarpus angolensis, Terminalia sericea and Gunnera perpensa, plants documented as being used for topical wound healing in the literature, were tested...
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| Veröffentlicht in: | Journal of ethnopharmacology 2004-12, Vol.95 (2), p.353-357 |
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| container_title | Journal of ethnopharmacology |
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| creator | Steenkamp, V. Mathivha, E. Gouws, M.C. van Rensburg, C.E.J. |
| description | Aqueous and methanol extracts of
Urtica urens,
Capparis tomentosa,
Dicoma anomala,
Leonotis leonorus,
Xysmalobium undulatum,
Helichrysum foetidum,
Pterocarpus angolensis,
Terminalia sericea and
Gunnera perpensa, plants documented as being used for topical wound healing in the literature, were tested for antibacterial activity against
Staphylococcus aureus,
Streptococcus pyogenes,
Escherichia coli and
Pseudomonas aeruginosa. Methanol and water extracts of two of these plants,
Terminalia sericea and
Gunnera perpensa, were more active compared to the other extracts against
Streptococcus pyogenes and
Staphylococcus aureus. The effects of the latter plants on fibroblast growth as well as oxidant production by
N-formyl-methionyl-leucyl-phenylalanine were also studied. The water and methanol extracts of
Terminalia sericea and
Gunnera perpensa significantly decreased luciginin enhanced chemiluminescence at concentrations of 100
μg/ml and higher. However, the extracts had no effect on the growth of primary human fibroblasts. |
| doi_str_mv | 10.1016/j.jep.2004.08.020 |
| format | Article |
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Urtica urens,
Capparis tomentosa,
Dicoma anomala,
Leonotis leonorus,
Xysmalobium undulatum,
Helichrysum foetidum,
Pterocarpus angolensis,
Terminalia sericea and
Gunnera perpensa, plants documented as being used for topical wound healing in the literature, were tested for antibacterial activity against
Staphylococcus aureus,
Streptococcus pyogenes,
Escherichia coli and
Pseudomonas aeruginosa. Methanol and water extracts of two of these plants,
Terminalia sericea and
Gunnera perpensa, were more active compared to the other extracts against
Streptococcus pyogenes and
Staphylococcus aureus. The effects of the latter plants on fibroblast growth as well as oxidant production by
N-formyl-methionyl-leucyl-phenylalanine were also studied. The water and methanol extracts of
Terminalia sericea and
Gunnera perpensa significantly decreased luciginin enhanced chemiluminescence at concentrations of 100
μg/ml and higher. However, the extracts had no effect on the growth of primary human fibroblasts.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2004.08.020</identifier><identifier>PMID: 15507359</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Anti-Bacterial Agents - isolation & purification ; Anti-Bacterial Agents - pharmacology ; Antibacterial ; antibacterial properties ; Antioxidant ; antioxidant activity ; Antioxidants - isolation & purification ; Antioxidants - pharmacology ; Biological and medical sciences ; Cells, Cultured ; Dose-Response Relationship, Drug ; fibroblast growth factors ; fibroblasts ; Fibroblasts - drug effects ; General pharmacology ; herbal medicines ; Herbal remedies ; Humans ; Medical sciences ; medicinal plants ; Medicine, African Traditional ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; plant extracts ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Plant Structures ; South Africa ; tissue repair ; Wound Healing - drug effects ; Wounds</subject><ispartof>Journal of ethnopharmacology, 2004-12, Vol.95 (2), p.353-357</ispartof><rights>2004 Elsevier Ireland Ltd</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c501t-25f9558f7d01e5e992d8f216e734a9015830ab2a7d16a144809d4c8d17d32a213</citedby><cites>FETCH-LOGICAL-c501t-25f9558f7d01e5e992d8f216e734a9015830ab2a7d16a144809d4c8d17d32a213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378874104004039$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16238705$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15507359$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Steenkamp, V.</creatorcontrib><creatorcontrib>Mathivha, E.</creatorcontrib><creatorcontrib>Gouws, M.C.</creatorcontrib><creatorcontrib>van Rensburg, C.E.J.</creatorcontrib><title>Studies on antibacterial, antioxidant and fibroblast growth stimulation of wound healing remedies from South Africa</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Aqueous and methanol extracts of
Urtica urens,
Capparis tomentosa,
Dicoma anomala,
Leonotis leonorus,
Xysmalobium undulatum,
Helichrysum foetidum,
Pterocarpus angolensis,
Terminalia sericea and
Gunnera perpensa, plants documented as being used for topical wound healing in the literature, were tested for antibacterial activity against
Staphylococcus aureus,
Streptococcus pyogenes,
Escherichia coli and
Pseudomonas aeruginosa. Methanol and water extracts of two of these plants,
Terminalia sericea and
Gunnera perpensa, were more active compared to the other extracts against
Streptococcus pyogenes and
Staphylococcus aureus. The effects of the latter plants on fibroblast growth as well as oxidant production by
N-formyl-methionyl-leucyl-phenylalanine were also studied. The water and methanol extracts of
Terminalia sericea and
Gunnera perpensa significantly decreased luciginin enhanced chemiluminescence at concentrations of 100
μg/ml and higher. However, the extracts had no effect on the growth of primary human fibroblasts.</description><subject>Anti-Bacterial Agents - isolation & purification</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial</subject><subject>antibacterial properties</subject><subject>Antioxidant</subject><subject>antioxidant activity</subject><subject>Antioxidants - isolation & purification</subject><subject>Antioxidants - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>Dose-Response Relationship, Drug</subject><subject>fibroblast growth factors</subject><subject>fibroblasts</subject><subject>Fibroblasts - drug effects</subject><subject>General pharmacology</subject><subject>herbal medicines</subject><subject>Herbal remedies</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>Medicine, African Traditional</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>plant extracts</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Structures</subject><subject>South Africa</subject><subject>tissue repair</subject><subject>Wound Healing - drug effects</subject><subject>Wounds</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90U1v1DAQBmALgehS-AFcIBfgQsLYiWNHnKqKL6kSh6Vna-LYW6-SeLETCv-eaXel3noaW3pmNJqXsdccKg68_bSv9u5QCYCmAl2BgCdsw7USpZKqfso2UCtdatXwM_Yi5z0AKN7Ac3bGpQRVy27D8nZZh-ByEecC5yX0aBeXAo4f77_xbxio0nsofOhT7EfMS7FL8Xa5KfISpnVEYnMRfXEbV2I3Dscw74rkJnc_2ac4Fdu4UsOFT8HiS_bM45jdq1M9Z9dfv_y6_F5e_fz24_LiqrQS-FIK6TsptVcDcCdd14lBe8Fbp-oGO-BS14C9QDXwFnnTaOiGxuqBq6EWKHh9zj4c5x5S_L26vJgpZOvGEWcX12yU4q2iU2mS7x-VrQJeN01LkB-hTTHn5Lw5pDBh-mc4mLtMzN5QJuYuEwPaUCbU8-Y0fO3pJA8dpxAIvDsBzBZHn3C2IT-4VtRagST39ug8RoO7ROZ6K2gzgE4DVRKfj8LRWf8El0y2wc2WgkjOLmaI4ZFF_wMbEbMC</recordid><startdate>20041201</startdate><enddate>20041201</enddate><creator>Steenkamp, V.</creator><creator>Mathivha, E.</creator><creator>Gouws, M.C.</creator><creator>van Rensburg, C.E.J.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20041201</creationdate><title>Studies on antibacterial, antioxidant and fibroblast growth stimulation of wound healing remedies from South Africa</title><author>Steenkamp, V. ; Mathivha, E. ; Gouws, M.C. ; van Rensburg, C.E.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c501t-25f9558f7d01e5e992d8f216e734a9015830ab2a7d16a144809d4c8d17d32a213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Anti-Bacterial Agents - isolation & purification</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibacterial</topic><topic>antibacterial properties</topic><topic>Antioxidant</topic><topic>antioxidant activity</topic><topic>Antioxidants - isolation & purification</topic><topic>Antioxidants - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>Dose-Response Relationship, Drug</topic><topic>fibroblast growth factors</topic><topic>fibroblasts</topic><topic>Fibroblasts - drug effects</topic><topic>General pharmacology</topic><topic>herbal medicines</topic><topic>Herbal remedies</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>Medicine, African Traditional</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>plant extracts</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Structures</topic><topic>South Africa</topic><topic>tissue repair</topic><topic>Wound Healing - drug effects</topic><topic>Wounds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Steenkamp, V.</creatorcontrib><creatorcontrib>Mathivha, E.</creatorcontrib><creatorcontrib>Gouws, M.C.</creatorcontrib><creatorcontrib>van Rensburg, C.E.J.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Steenkamp, V.</au><au>Mathivha, E.</au><au>Gouws, M.C.</au><au>van Rensburg, C.E.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Studies on antibacterial, antioxidant and fibroblast growth stimulation of wound healing remedies from South Africa</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2004-12-01</date><risdate>2004</risdate><volume>95</volume><issue>2</issue><spage>353</spage><epage>357</epage><pages>353-357</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>Aqueous and methanol extracts of
Urtica urens,
Capparis tomentosa,
Dicoma anomala,
Leonotis leonorus,
Xysmalobium undulatum,
Helichrysum foetidum,
Pterocarpus angolensis,
Terminalia sericea and
Gunnera perpensa, plants documented as being used for topical wound healing in the literature, were tested for antibacterial activity against
Staphylococcus aureus,
Streptococcus pyogenes,
Escherichia coli and
Pseudomonas aeruginosa. Methanol and water extracts of two of these plants,
Terminalia sericea and
Gunnera perpensa, were more active compared to the other extracts against
Streptococcus pyogenes and
Staphylococcus aureus. The effects of the latter plants on fibroblast growth as well as oxidant production by
N-formyl-methionyl-leucyl-phenylalanine were also studied. The water and methanol extracts of
Terminalia sericea and
Gunnera perpensa significantly decreased luciginin enhanced chemiluminescence at concentrations of 100
μg/ml and higher. However, the extracts had no effect on the growth of primary human fibroblasts.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>15507359</pmid><doi>10.1016/j.jep.2004.08.020</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of ethnopharmacology, 2004-12, Vol.95 (2), p.353-357 |
| issn | 0378-8741 1872-7573 |
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| subjects | Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibacterial antibacterial properties Antioxidant antioxidant activity Antioxidants - isolation & purification Antioxidants - pharmacology Biological and medical sciences Cells, Cultured Dose-Response Relationship, Drug fibroblast growth factors fibroblasts Fibroblasts - drug effects General pharmacology herbal medicines Herbal remedies Humans Medical sciences medicinal plants Medicine, African Traditional Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments plant extracts Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Structures South Africa tissue repair Wound Healing - drug effects Wounds |
| title | Studies on antibacterial, antioxidant and fibroblast growth stimulation of wound healing remedies from South Africa |
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