Crosstalk signaling between mitochondrial Ca2+ and ROS

Mitochondria are central to energy metabolism as the source of much of the cell's ATP, as well as being a hub for cellular Ca2+ signaling. Mitochondrial Ca2+ is a positive effector of ATP synthesis, yet Ca2+ overload can lead to mitochondrial dysfunction and cell death. Moreover, Ca2+ uptake by...

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Veröffentlicht in:	Frontiers in bioscience 2009-01, Vol.14 (4), p.1197-1218
Hauptverfasser:	Feissner, Robert F, Skalska, Jolanta, Gaum, Winston E, Sheu, Shey-Shing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism Mice Mitochondria - metabolism Reactive Oxygen Species - metabolism Receptor Cross-Talk Signal Transduction
Online-Zugang:	Volltext
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