Metabolism-blocked antifolates as potential anti-rheumatoid arthritis agents: 4-Amino-4-deoxy-5,8,10-trideazapteroyl- d, l-4′-methyleneglutamic acid (CH-1504) and its analogs

4-Amino-4-deoxy-5,8,10-trideazapteroyl- d, l-4′-methyleneglutamic acid (CH-1504) is the prototype of a potentially therapeutically more selective class of antifolates for rheumatoid arthritis treatment. This class is characterized by retention of dihydrofolate reductase (DHFR; EC 1.5.1.3) as their l...

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