Exogenous alpha-1-acid glycoprotein protects against renal ischemia-reperfusion injury by inhibition of inflammation and apoptosis

Although ischemia-reperfusion (I/R) injury represents a major problem in posttransplant organ failure, effective treatment is not available. The acute phase protein alpha-1-acid glycoprotein (AGP) has been shown to be protective against experimental I/R injury. The effects of AGP are thought to be m...

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Veröffentlicht in:	Transplantation 2004-10, Vol.78 (8), p.1116-1124
Hauptverfasser:	DE VRIES, Bart, WALTER, Sarah J, WOLFS, Tim G. A. M, HOCHEPIED, Tino, RÄBINÄ, Jarkko, HEERINGA, Peter, PARKKINEN, Jaakko, LIBERT, Claude, BUURMAN, Wim A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Biological and medical sciences Cytoskeleton - drug effects Cytoskeleton - ultrastructure Dose-Response Relationship, Drug Fucose - metabolism Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Inflammation - prevention & control Medical sciences Mice Mice, Transgenic Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Orosomucoid - administration & dosage Orosomucoid - genetics Orosomucoid - metabolism Orosomucoid - pharmacology Rats Renal Circulation Renovascular diseases Reperfusion Injury - pathology Reperfusion Injury - physiopathology Reperfusion Injury - prevention & control Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue, organ and graft immunology
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