Preparation and characterization of N-(3-pyridinyl) spirocyclic diamines as ligands for nicotinic acetylcholine receptors

Several N-pyridin-3-yl spirobicyclic diamines, designed as conformationally restricted analogs of tebanicline (ABT-594), were synthesized as novel ligands for nicotinic acetylcholine receptors (nAChR). The spirocyclic compounds exhibited weaker binding affinity, than other constrained analogs in acc...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2009-03, Vol.19 (6), p.1682-1685
Hauptverfasser:	SIPPY, Kevin B, ANDERSON, David J, BUNNELLE, William H, HUTCHINS, Charles W, SCHRIMPF, Michael R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Azetidines - chemical synthesis Azetidines - pharmacology Biological and medical sciences Chemistry, Pharmaceutical - methods Cholinergic system Diamines - chemistry Drug Design Humans Kinetics Ligands Medical sciences Models, Chemical Molecular Conformation Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Pyridines - chemical synthesis Pyridines - pharmacology Rats Receptors, Nicotinic - chemistry Structure-Activity Relationship
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