Performance of Malaria Rapid Diagnostic Tests as Part of Routine Malaria Case Management in Kenya
Data on malaria rapid diagnostic test (RDT) performance under routine program conditions are limited. We assessed the attributes of RDTs performed by study and health facility (HF) staffs as part of routine malaria case management of patients > or = 5 years of age in Kenya. Expert microscopy was...
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| Veröffentlicht in: | The American journal of tropical medicine and hygiene 2009-03, Vol.80 (3), p.470-474 |
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| creator | de Oliveira, Alexandre Macedo Skarbinski, Jacek Ouma, Peter O Kariuki, Simon Barnwell, John W Otieno, Kephas Onyona, Phillip Causer, Louise M Laserson, Kayla F Akhwale, Willis S Slutsker, Laurence Hamel, Mary |
| description | Data on malaria rapid diagnostic test (RDT) performance under routine program conditions are limited. We assessed the attributes of RDTs performed by study and health facility (HF) staffs as part of routine malaria case management of patients > or = 5 years of age in Kenya. Expert microscopy was used as our gold standard. A total of 1,827 patients were enrolled; 191 (11.6%) were parasitemic by expert microscopy. Sensitivity and specificity of RDTs performed by study staff were 86.6% (95% confidence interval [CI]: 79.8-93.5%) and 95.4% (95% CI: 93.9-96.9%), respectively. Among tests performed by HF staff, RDTs were 91.7% (95% CI: 80.8-100.0%) sensitive and 96.7% (95% CI: 92.8-100.0%) specific, whereas microscopy was 52.5% (95% CI: 33.2-71.9%) sensitive and 77.0% (95% CI: 67.9-86.2%) specific. Our findings suggest that RDTs perform better than microscopy under routine conditions. Further efforts are needed to maintain this high RDT performance over time. |
| doi_str_mv | 10.4269/ajtmh.2009.80.470 |
| format | Article |
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We assessed the attributes of RDTs performed by study and health facility (HF) staffs as part of routine malaria case management of patients > or = 5 years of age in Kenya. Expert microscopy was used as our gold standard. A total of 1,827 patients were enrolled; 191 (11.6%) were parasitemic by expert microscopy. Sensitivity and specificity of RDTs performed by study staff were 86.6% (95% confidence interval [CI]: 79.8-93.5%) and 95.4% (95% CI: 93.9-96.9%), respectively. Among tests performed by HF staff, RDTs were 91.7% (95% CI: 80.8-100.0%) sensitive and 96.7% (95% CI: 92.8-100.0%) specific, whereas microscopy was 52.5% (95% CI: 33.2-71.9%) sensitive and 77.0% (95% CI: 67.9-86.2%) specific. Our findings suggest that RDTs perform better than microscopy under routine conditions. 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We assessed the attributes of RDTs performed by study and health facility (HF) staffs as part of routine malaria case management of patients > or = 5 years of age in Kenya. Expert microscopy was used as our gold standard. A total of 1,827 patients were enrolled; 191 (11.6%) were parasitemic by expert microscopy. Sensitivity and specificity of RDTs performed by study staff were 86.6% (95% confidence interval [CI]: 79.8-93.5%) and 95.4% (95% CI: 93.9-96.9%), respectively. Among tests performed by HF staff, RDTs were 91.7% (95% CI: 80.8-100.0%) sensitive and 96.7% (95% CI: 92.8-100.0%) specific, whereas microscopy was 52.5% (95% CI: 33.2-71.9%) sensitive and 77.0% (95% CI: 67.9-86.2%) specific. Our findings suggest that RDTs perform better than microscopy under routine conditions. 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Skarbinski, Jacek ; Ouma, Peter O ; Kariuki, Simon ; Barnwell, John W ; Otieno, Kephas ; Onyona, Phillip ; Causer, Louise M ; Laserson, Kayla F ; Akhwale, Willis S ; Slutsker, Laurence ; Hamel, Mary</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-a3587808669fbf983c6584b2123c8bb06d331eb347d868842c338f155c6006c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Antimalarials - therapeutic use</topic><topic>Artemisinins - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Case Management</topic><topic>Drug Combinations</topic><topic>Ethanolamines - therapeutic use</topic><topic>Fluorenes - therapeutic use</topic><topic>Health Facilities</topic><topic>Human protozoal diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Kenya - epidemiology</topic><topic>Malaria</topic><topic>Malaria - diagnosis</topic><topic>Malaria - drug therapy</topic><topic>Malaria - epidemiology</topic><topic>Medical sciences</topic><topic>Parasitemia - diagnosis</topic><topic>Parasitemia - drug therapy</topic><topic>Parasitemia - epidemiology</topic><topic>Parasitic diseases</topic><topic>Predictive Value of Tests</topic><topic>Protozoal diseases</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Oliveira, Alexandre Macedo</creatorcontrib><creatorcontrib>Skarbinski, Jacek</creatorcontrib><creatorcontrib>Ouma, Peter O</creatorcontrib><creatorcontrib>Kariuki, Simon</creatorcontrib><creatorcontrib>Barnwell, John W</creatorcontrib><creatorcontrib>Otieno, Kephas</creatorcontrib><creatorcontrib>Onyona, Phillip</creatorcontrib><creatorcontrib>Causer, Louise M</creatorcontrib><creatorcontrib>Laserson, Kayla F</creatorcontrib><creatorcontrib>Akhwale, Willis S</creatorcontrib><creatorcontrib>Slutsker, Laurence</creatorcontrib><creatorcontrib>Hamel, Mary</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of tropical medicine and hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Oliveira, Alexandre Macedo</au><au>Skarbinski, Jacek</au><au>Ouma, Peter O</au><au>Kariuki, Simon</au><au>Barnwell, John W</au><au>Otieno, Kephas</au><au>Onyona, Phillip</au><au>Causer, Louise M</au><au>Laserson, Kayla F</au><au>Akhwale, Willis S</au><au>Slutsker, Laurence</au><au>Hamel, Mary</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Performance of Malaria Rapid Diagnostic Tests as Part of Routine Malaria Case Management in Kenya</atitle><jtitle>The American journal of tropical medicine and hygiene</jtitle><addtitle>Am J Trop Med Hyg</addtitle><date>2009-03-01</date><risdate>2009</risdate><volume>80</volume><issue>3</issue><spage>470</spage><epage>474</epage><pages>470-474</pages><issn>0002-9637</issn><eissn>1476-1645</eissn><coden>AJTHAB</coden><abstract>Data on malaria rapid diagnostic test (RDT) performance under routine program conditions are limited. We assessed the attributes of RDTs performed by study and health facility (HF) staffs as part of routine malaria case management of patients > or = 5 years of age in Kenya. Expert microscopy was used as our gold standard. A total of 1,827 patients were enrolled; 191 (11.6%) were parasitemic by expert microscopy. Sensitivity and specificity of RDTs performed by study staff were 86.6% (95% confidence interval [CI]: 79.8-93.5%) and 95.4% (95% CI: 93.9-96.9%), respectively. Among tests performed by HF staff, RDTs were 91.7% (95% CI: 80.8-100.0%) sensitive and 96.7% (95% CI: 92.8-100.0%) specific, whereas microscopy was 52.5% (95% CI: 33.2-71.9%) sensitive and 77.0% (95% CI: 67.9-86.2%) specific. Our findings suggest that RDTs perform better than microscopy under routine conditions. Further efforts are needed to maintain this high RDT performance over time.</abstract><cop>Deerfield, IL</cop><pub>ASTMH</pub><pmid>19270300</pmid><doi>10.4269/ajtmh.2009.80.470</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antimalarials - therapeutic use Artemisinins - therapeutic use Biological and medical sciences Case Management Drug Combinations Ethanolamines - therapeutic use Fluorenes - therapeutic use Health Facilities Human protozoal diseases Humans Infectious diseases Kenya - epidemiology Malaria Malaria - diagnosis Malaria - drug therapy Malaria - epidemiology Medical sciences Parasitemia - diagnosis Parasitemia - drug therapy Parasitemia - epidemiology Parasitic diseases Predictive Value of Tests Protozoal diseases Sensitivity and Specificity |
| title | Performance of Malaria Rapid Diagnostic Tests as Part of Routine Malaria Case Management in Kenya |
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