Lithium modulation of the human inositol monophosphatase 2 ( IMPA2) promoter
The inositol-signaling pathway is a therapeutic target for lithium in the treatment of bipolar disorder. Inositol monophosphatases (IMPases) play a key role in inositol signaling. Lithium’s ability to inhibit IMPase 1 is well known, but its effect on IMPase 2 or on the transcriptional regulation of...
Gespeichert in:
| Veröffentlicht in: | Biochemical and biophysical research communications 2004-11, Vol.324 (4), p.1370-1378 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1378 |
|---|---|
| container_issue | 4 |
| container_start_page | 1370 |
| container_title | Biochemical and biophysical research communications |
| container_volume | 324 |
| creator | Seelan, Ratnam S. Parthasarathy, Latha K. Parthasarathy, Ranga N. |
| description | The inositol-signaling pathway is a therapeutic target for lithium in the treatment of bipolar disorder. Inositol monophosphatases (IMPases) play a key role in inositol signaling. Lithium’s ability to inhibit IMPase 1 is well known, but its effect on IMPase 2 or on the transcriptional regulation of these genes has not been studied. Here, we report the identification and characterization of the minimal promoter of
IMPA2 (encoding IMPase 2) in HeLa (epithelial) and SK-N-AS (neuronal) cells.
IMPA2 promoter activity appears to be contributed by different elements in the 5′ flanking region, suggesting that the gene is differentially regulated in neuronal and non-neuronal cells. Furthermore,
IMPA2 promoter activity in both cell lines is downregulated, in a dose-dependent manner, by lithium after treatment for only 24
h. This effect is also observed in vivo. Our results suggest a possible role for
IMPA2 in bipolar disorder. |
| doi_str_mv | 10.1016/j.bbrc.2004.09.199 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67005953</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006291X04022685</els_id><sourcerecordid>67005953</sourcerecordid><originalsourceid>FETCH-LOGICAL-c385t-c224b587c5c27d8651a5a5cab84c53363c84a97f704b72a091a57e5ac95643e53</originalsourceid><addsrcrecordid>eNqFkE1r3DAQQEVoaDZp_0AOQaeSHuyOZH1Y0EsIaRLY0hwayE3IshZrsa2tJBfy76NlF3JrT3OYN2_gIXRJoCZAxLdt3XXR1hSA1aBqotQJWhFQUFEC7ANaAYCoqCIvZ-g8pS0AIUyoj-iMcA6sEXyF1mufB79MeAr9Mprsw4zDBufB4WGZzIz9HJLPYSzAHHZDSLvBZJMcpvgaP_58uqFf8S6GKWQXP6HTjRmT-3ycF-j5x93v24dq_ev-8fZmXdmm5bmylLKOt9JyS2XfCk4MN9yarmWWN41obMuMkhsJrJPUgCp76bixigvWON5coC8Hb3n8Z3Ep68kn68bRzC4sSQsJwFVR_Q8ksuVMCFlAegBtDClFt9G76CcTXzUBvY-tt3ofW-9ja1C6xC5HV0f70k2ufz851i3A9wPgSoy_3kWdrHezdb2PzmbdB_8v_xvu2o68</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17854667</pqid></control><display><type>article</type><title>Lithium modulation of the human inositol monophosphatase 2 ( IMPA2) promoter</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Seelan, Ratnam S. ; Parthasarathy, Latha K. ; Parthasarathy, Ranga N.</creator><creatorcontrib>Seelan, Ratnam S. ; Parthasarathy, Latha K. ; Parthasarathy, Ranga N.</creatorcontrib><description>The inositol-signaling pathway is a therapeutic target for lithium in the treatment of bipolar disorder. Inositol monophosphatases (IMPases) play a key role in inositol signaling. Lithium’s ability to inhibit IMPase 1 is well known, but its effect on IMPase 2 or on the transcriptional regulation of these genes has not been studied. Here, we report the identification and characterization of the minimal promoter of
IMPA2 (encoding IMPase 2) in HeLa (epithelial) and SK-N-AS (neuronal) cells.
IMPA2 promoter activity appears to be contributed by different elements in the 5′ flanking region, suggesting that the gene is differentially regulated in neuronal and non-neuronal cells. Furthermore,
IMPA2 promoter activity in both cell lines is downregulated, in a dose-dependent manner, by lithium after treatment for only 24
h. This effect is also observed in vivo. Our results suggest a possible role for
IMPA2 in bipolar disorder.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2004.09.199</identifier><identifier>PMID: 15504365</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Antimanic Agents - pharmacology ; Base Sequence ; Bipolar disorder ; Cell Line ; Down-Regulation ; Gene Expression - drug effects ; HeLa ; HeLa Cells ; Humans ; IMPase 1 ; IMPase 2 ; Inositol ; Lithium ; Lithium Chloride - pharmacology ; Molecular Sequence Data ; Phosphoric Monoester Hydrolases - biosynthesis ; Phosphoric Monoester Hydrolases - genetics ; Promoter Regions, Genetic ; SK-N-AS ; Transcription Initiation Site</subject><ispartof>Biochemical and biophysical research communications, 2004-11, Vol.324 (4), p.1370-1378</ispartof><rights>2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-c224b587c5c27d8651a5a5cab84c53363c84a97f704b72a091a57e5ac95643e53</citedby><cites>FETCH-LOGICAL-c385t-c224b587c5c27d8651a5a5cab84c53363c84a97f704b72a091a57e5ac95643e53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006291X04022685$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15504365$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seelan, Ratnam S.</creatorcontrib><creatorcontrib>Parthasarathy, Latha K.</creatorcontrib><creatorcontrib>Parthasarathy, Ranga N.</creatorcontrib><title>Lithium modulation of the human inositol monophosphatase 2 ( IMPA2) promoter</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>The inositol-signaling pathway is a therapeutic target for lithium in the treatment of bipolar disorder. Inositol monophosphatases (IMPases) play a key role in inositol signaling. Lithium’s ability to inhibit IMPase 1 is well known, but its effect on IMPase 2 or on the transcriptional regulation of these genes has not been studied. Here, we report the identification and characterization of the minimal promoter of
IMPA2 (encoding IMPase 2) in HeLa (epithelial) and SK-N-AS (neuronal) cells.
IMPA2 promoter activity appears to be contributed by different elements in the 5′ flanking region, suggesting that the gene is differentially regulated in neuronal and non-neuronal cells. Furthermore,
IMPA2 promoter activity in both cell lines is downregulated, in a dose-dependent manner, by lithium after treatment for only 24
h. This effect is also observed in vivo. Our results suggest a possible role for
IMPA2 in bipolar disorder.</description><subject>Antimanic Agents - pharmacology</subject><subject>Base Sequence</subject><subject>Bipolar disorder</subject><subject>Cell Line</subject><subject>Down-Regulation</subject><subject>Gene Expression - drug effects</subject><subject>HeLa</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>IMPase 1</subject><subject>IMPase 2</subject><subject>Inositol</subject><subject>Lithium</subject><subject>Lithium Chloride - pharmacology</subject><subject>Molecular Sequence Data</subject><subject>Phosphoric Monoester Hydrolases - biosynthesis</subject><subject>Phosphoric Monoester Hydrolases - genetics</subject><subject>Promoter Regions, Genetic</subject><subject>SK-N-AS</subject><subject>Transcription Initiation Site</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQQEVoaDZp_0AOQaeSHuyOZH1Y0EsIaRLY0hwayE3IshZrsa2tJBfy76NlF3JrT3OYN2_gIXRJoCZAxLdt3XXR1hSA1aBqotQJWhFQUFEC7ANaAYCoqCIvZ-g8pS0AIUyoj-iMcA6sEXyF1mufB79MeAr9Mprsw4zDBufB4WGZzIz9HJLPYSzAHHZDSLvBZJMcpvgaP_58uqFf8S6GKWQXP6HTjRmT-3ycF-j5x93v24dq_ev-8fZmXdmm5bmylLKOt9JyS2XfCk4MN9yarmWWN41obMuMkhsJrJPUgCp76bixigvWON5coC8Hb3n8Z3Ep68kn68bRzC4sSQsJwFVR_Q8ksuVMCFlAegBtDClFt9G76CcTXzUBvY-tt3ofW-9ja1C6xC5HV0f70k2ufz851i3A9wPgSoy_3kWdrHezdb2PzmbdB_8v_xvu2o68</recordid><startdate>20041126</startdate><enddate>20041126</enddate><creator>Seelan, Ratnam S.</creator><creator>Parthasarathy, Latha K.</creator><creator>Parthasarathy, Ranga N.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>20041126</creationdate><title>Lithium modulation of the human inositol monophosphatase 2 ( IMPA2) promoter</title><author>Seelan, Ratnam S. ; Parthasarathy, Latha K. ; Parthasarathy, Ranga N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-c224b587c5c27d8651a5a5cab84c53363c84a97f704b72a091a57e5ac95643e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Antimanic Agents - pharmacology</topic><topic>Base Sequence</topic><topic>Bipolar disorder</topic><topic>Cell Line</topic><topic>Down-Regulation</topic><topic>Gene Expression - drug effects</topic><topic>HeLa</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>IMPase 1</topic><topic>IMPase 2</topic><topic>Inositol</topic><topic>Lithium</topic><topic>Lithium Chloride - pharmacology</topic><topic>Molecular Sequence Data</topic><topic>Phosphoric Monoester Hydrolases - biosynthesis</topic><topic>Phosphoric Monoester Hydrolases - genetics</topic><topic>Promoter Regions, Genetic</topic><topic>SK-N-AS</topic><topic>Transcription Initiation Site</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seelan, Ratnam S.</creatorcontrib><creatorcontrib>Parthasarathy, Latha K.</creatorcontrib><creatorcontrib>Parthasarathy, Ranga N.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seelan, Ratnam S.</au><au>Parthasarathy, Latha K.</au><au>Parthasarathy, Ranga N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lithium modulation of the human inositol monophosphatase 2 ( IMPA2) promoter</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2004-11-26</date><risdate>2004</risdate><volume>324</volume><issue>4</issue><spage>1370</spage><epage>1378</epage><pages>1370-1378</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>The inositol-signaling pathway is a therapeutic target for lithium in the treatment of bipolar disorder. Inositol monophosphatases (IMPases) play a key role in inositol signaling. Lithium’s ability to inhibit IMPase 1 is well known, but its effect on IMPase 2 or on the transcriptional regulation of these genes has not been studied. Here, we report the identification and characterization of the minimal promoter of
IMPA2 (encoding IMPase 2) in HeLa (epithelial) and SK-N-AS (neuronal) cells.
IMPA2 promoter activity appears to be contributed by different elements in the 5′ flanking region, suggesting that the gene is differentially regulated in neuronal and non-neuronal cells. Furthermore,
IMPA2 promoter activity in both cell lines is downregulated, in a dose-dependent manner, by lithium after treatment for only 24
h. This effect is also observed in vivo. Our results suggest a possible role for
IMPA2 in bipolar disorder.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>15504365</pmid><doi>10.1016/j.bbrc.2004.09.199</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-291X |
| ispartof | Biochemical and biophysical research communications, 2004-11, Vol.324 (4), p.1370-1378 |
| issn | 0006-291X 1090-2104 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67005953 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Antimanic Agents - pharmacology Base Sequence Bipolar disorder Cell Line Down-Regulation Gene Expression - drug effects HeLa HeLa Cells Humans IMPase 1 IMPase 2 Inositol Lithium Lithium Chloride - pharmacology Molecular Sequence Data Phosphoric Monoester Hydrolases - biosynthesis Phosphoric Monoester Hydrolases - genetics Promoter Regions, Genetic SK-N-AS Transcription Initiation Site |
| title | Lithium modulation of the human inositol monophosphatase 2 ( IMPA2) promoter |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T22%3A32%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Lithium%20modulation%20of%20the%20human%20inositol%20monophosphatase%202%20(%20IMPA2)%20promoter&rft.jtitle=Biochemical%20and%20biophysical%20research%20communications&rft.au=Seelan,%20Ratnam%20S.&rft.date=2004-11-26&rft.volume=324&rft.issue=4&rft.spage=1370&rft.epage=1378&rft.pages=1370-1378&rft.issn=0006-291X&rft.eissn=1090-2104&rft_id=info:doi/10.1016/j.bbrc.2004.09.199&rft_dat=%3Cproquest_cross%3E67005953%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17854667&rft_id=info:pmid/15504365&rft_els_id=S0006291X04022685&rfr_iscdi=true |