The role of perforin-mediated apoptosis in lichen planus lesions
Lichen planus is recognized as a T-cell-mediated disease. Histologically, it is characterized by the formation of colloid bodies representing apoptotic keratinocytes. The apoptotic process mediated by CD8(+) cytotoxic T lymphocytes (CTLs) and NK cells mainly involves two distinct pathways: the perfo...
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| Veröffentlicht in: | Archives of Dermatological Research 2004-10, Vol.296 (5), p.226-230 |
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| description | Lichen planus is recognized as a T-cell-mediated disease. Histologically, it is characterized by the formation of colloid bodies representing apoptotic keratinocytes. The apoptotic process mediated by CD8(+) cytotoxic T lymphocytes (CTLs) and NK cells mainly involves two distinct pathways: the perforin/granzyme pathway and the Fas/FasL pathway. So far, little is known regarding the role of perforin-mediated apoptosis in lichen planus. In the present study, the expression and distribution of perforin, T and NK cell subsets in the epidermis and dermis of lesional and nonlesional lichen planus skin were studied. Skin biopsy specimens from lesional and nonlesional skin of ten patients with lichen planus and eight healthy persons were analysed by immunohistochemistry. Significant accumulation of T cells, particularly of CD4(+) and CD8(+) subsets, was found in both epidermis and dermis of lichen planus lesions compared with nonlesional and healthy skin. There were no significant differences in the incidence of NK cells (CD16(+) and CD56(+)) between lesional, nonlesional and healthy skin. Perforin expression was significantly upregulated in the epidermis of lichen planus lesions. In conclusion, accumulation of perforin(+) cells in the epidermis of lichen planus lesions suggest a potential role of perforin in the apoptosis of basal keratinocytes. |
| doi_str_mv | 10.1007/s00403-004-0512-1 |
| format | Article |
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Histologically, it is characterized by the formation of colloid bodies representing apoptotic keratinocytes. The apoptotic process mediated by CD8(+) cytotoxic T lymphocytes (CTLs) and NK cells mainly involves two distinct pathways: the perforin/granzyme pathway and the Fas/FasL pathway. So far, little is known regarding the role of perforin-mediated apoptosis in lichen planus. In the present study, the expression and distribution of perforin, T and NK cell subsets in the epidermis and dermis of lesional and nonlesional lichen planus skin were studied. Skin biopsy specimens from lesional and nonlesional skin of ten patients with lichen planus and eight healthy persons were analysed by immunohistochemistry. Significant accumulation of T cells, particularly of CD4(+) and CD8(+) subsets, was found in both epidermis and dermis of lichen planus lesions compared with nonlesional and healthy skin. There were no significant differences in the incidence of NK cells (CD16(+) and CD56(+)) between lesional, nonlesional and healthy skin. Perforin expression was significantly upregulated in the epidermis of lichen planus lesions. In conclusion, accumulation of perforin(+) cells in the epidermis of lichen planus lesions suggest a potential role of perforin in the apoptosis of basal keratinocytes.</description><identifier>ISSN: 0340-3696</identifier><identifier>EISSN: 1432-069X</identifier><identifier>DOI: 10.1007/s00403-004-0512-1</identifier><identifier>PMID: 15452725</identifier><identifier>CODEN: ADREDL</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Apoptosis ; Biological and medical sciences ; Dermatology ; Dermis - metabolism ; Dermis - pathology ; Epidermis - metabolism ; Epidermis - pathology ; Humans ; Immunohistochemistry ; Killer Cells, Natural - pathology ; Lichen Planus - metabolism ; Lichen Planus - pathology ; Lichen Planus - physiopathology ; Medical sciences ; Membrane Glycoproteins - metabolism ; Middle Aged ; Perforin ; Pore Forming Cytotoxic Proteins ; Psoriasis. Parapsoriasis. Lichen ; Skin - metabolism ; Skin - pathology ; T-Lymphocyte Subsets - pathology</subject><ispartof>Archives of Dermatological Research, 2004-10, Vol.296 (5), p.226-230</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright Springer-Verlag 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-e0e1ce116cca6a9f39e0189b78a3a5386680538ed02777033a104cfdf61325173</citedby><cites>FETCH-LOGICAL-c420t-e0e1ce116cca6a9f39e0189b78a3a5386680538ed02777033a104cfdf61325173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16263139$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15452725$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KASTELAN, Marija</creatorcontrib><creatorcontrib>MASSARI, Larisa Prpic</creatorcontrib><creatorcontrib>GRUBER, Franjo</creatorcontrib><creatorcontrib>ZAMOLO, Gordana</creatorcontrib><creatorcontrib>ZAUHAR, Gordana</creatorcontrib><creatorcontrib>COKLO, Miran</creatorcontrib><creatorcontrib>RUKAVINA, Danijel</creatorcontrib><title>The role of perforin-mediated apoptosis in lichen planus lesions</title><title>Archives of Dermatological Research</title><addtitle>Arch Dermatol Res</addtitle><description>Lichen planus is recognized as a T-cell-mediated disease. Histologically, it is characterized by the formation of colloid bodies representing apoptotic keratinocytes. The apoptotic process mediated by CD8(+) cytotoxic T lymphocytes (CTLs) and NK cells mainly involves two distinct pathways: the perforin/granzyme pathway and the Fas/FasL pathway. So far, little is known regarding the role of perforin-mediated apoptosis in lichen planus. In the present study, the expression and distribution of perforin, T and NK cell subsets in the epidermis and dermis of lesional and nonlesional lichen planus skin were studied. Skin biopsy specimens from lesional and nonlesional skin of ten patients with lichen planus and eight healthy persons were analysed by immunohistochemistry. Significant accumulation of T cells, particularly of CD4(+) and CD8(+) subsets, was found in both epidermis and dermis of lichen planus lesions compared with nonlesional and healthy skin. There were no significant differences in the incidence of NK cells (CD16(+) and CD56(+)) between lesional, nonlesional and healthy skin. Perforin expression was significantly upregulated in the epidermis of lichen planus lesions. In conclusion, accumulation of perforin(+) cells in the epidermis of lichen planus lesions suggest a potential role of perforin in the apoptosis of basal keratinocytes.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>Dermatology</subject><subject>Dermis - metabolism</subject><subject>Dermis - pathology</subject><subject>Epidermis - metabolism</subject><subject>Epidermis - pathology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Killer Cells, Natural - pathology</subject><subject>Lichen Planus - metabolism</subject><subject>Lichen Planus - pathology</subject><subject>Lichen Planus - physiopathology</subject><subject>Medical sciences</subject><subject>Membrane Glycoproteins - metabolism</subject><subject>Middle Aged</subject><subject>Perforin</subject><subject>Pore Forming Cytotoxic Proteins</subject><subject>Psoriasis. 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Lichen</subject><subject>Skin - metabolism</subject><subject>Skin - pathology</subject><subject>T-Lymphocyte Subsets - pathology</subject><issn>0340-3696</issn><issn>1432-069X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkE1LAzEQhoMoWmp_gBdZBL1FZ5LdZPemiF9Q8KLgLaTpLKZsN2vSPfjvTWmh4BxmLs_MvDyMXSDcIoC-SwAlSJ47hwoFxyM2wVIKDqr5OmYTkCVwqRp1xmYprSCXhlKAPmVnWJWV0KKasPuPbypi6KgIbTFQbEP0PV_T0tsNLQs7hGETkk-F74vOu2_qi6Gz_ZiKjpIPfTpnJ63tEs32c8o-n58-Hl_5_P3l7fFhzl3-ueEEhI4QlXNW2aaVDQHWzULXVtpK1krVkActQWitQUqLULp22SqUokItp-xmd3eI4WektDFrnxx1OQyFMRmlAaq6KjN49Q9chTH2OZsRKAQ2EjFDuINcDClFas0Q_drGX4NgtnrNTq_J3Wz1mu3O5f7wuMiCDht7mRm43gM2Odu10fbOpwOnhJIoG_kH_Zl_xA</recordid><startdate>20041001</startdate><enddate>20041001</enddate><creator>KASTELAN, Marija</creator><creator>MASSARI, Larisa Prpic</creator><creator>GRUBER, Franjo</creator><creator>ZAMOLO, Gordana</creator><creator>ZAUHAR, Gordana</creator><creator>COKLO, Miran</creator><creator>RUKAVINA, Danijel</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20041001</creationdate><title>The role of perforin-mediated apoptosis in lichen planus lesions</title><author>KASTELAN, Marija ; MASSARI, Larisa Prpic ; GRUBER, Franjo ; ZAMOLO, Gordana ; ZAUHAR, Gordana ; COKLO, Miran ; RUKAVINA, Danijel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-e0e1ce116cca6a9f39e0189b78a3a5386680538ed02777033a104cfdf61325173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Apoptosis</topic><topic>Biological and medical sciences</topic><topic>Dermatology</topic><topic>Dermis - metabolism</topic><topic>Dermis - pathology</topic><topic>Epidermis - metabolism</topic><topic>Epidermis - pathology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Killer Cells, Natural - pathology</topic><topic>Lichen Planus - metabolism</topic><topic>Lichen Planus - pathology</topic><topic>Lichen Planus - physiopathology</topic><topic>Medical sciences</topic><topic>Membrane Glycoproteins - metabolism</topic><topic>Middle Aged</topic><topic>Perforin</topic><topic>Pore Forming Cytotoxic Proteins</topic><topic>Psoriasis. Parapsoriasis. Lichen</topic><topic>Skin - metabolism</topic><topic>Skin - pathology</topic><topic>T-Lymphocyte Subsets - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KASTELAN, Marija</creatorcontrib><creatorcontrib>MASSARI, Larisa Prpic</creatorcontrib><creatorcontrib>GRUBER, Franjo</creatorcontrib><creatorcontrib>ZAMOLO, Gordana</creatorcontrib><creatorcontrib>ZAUHAR, Gordana</creatorcontrib><creatorcontrib>COKLO, Miran</creatorcontrib><creatorcontrib>RUKAVINA, Danijel</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of Dermatological Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KASTELAN, Marija</au><au>MASSARI, Larisa Prpic</au><au>GRUBER, Franjo</au><au>ZAMOLO, Gordana</au><au>ZAUHAR, Gordana</au><au>COKLO, Miran</au><au>RUKAVINA, Danijel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of perforin-mediated apoptosis in lichen planus lesions</atitle><jtitle>Archives of Dermatological Research</jtitle><addtitle>Arch Dermatol Res</addtitle><date>2004-10-01</date><risdate>2004</risdate><volume>296</volume><issue>5</issue><spage>226</spage><epage>230</epage><pages>226-230</pages><issn>0340-3696</issn><eissn>1432-069X</eissn><coden>ADREDL</coden><abstract>Lichen planus is recognized as a T-cell-mediated disease. Histologically, it is characterized by the formation of colloid bodies representing apoptotic keratinocytes. The apoptotic process mediated by CD8(+) cytotoxic T lymphocytes (CTLs) and NK cells mainly involves two distinct pathways: the perforin/granzyme pathway and the Fas/FasL pathway. So far, little is known regarding the role of perforin-mediated apoptosis in lichen planus. In the present study, the expression and distribution of perforin, T and NK cell subsets in the epidermis and dermis of lesional and nonlesional lichen planus skin were studied. Skin biopsy specimens from lesional and nonlesional skin of ten patients with lichen planus and eight healthy persons were analysed by immunohistochemistry. Significant accumulation of T cells, particularly of CD4(+) and CD8(+) subsets, was found in both epidermis and dermis of lichen planus lesions compared with nonlesional and healthy skin. There were no significant differences in the incidence of NK cells (CD16(+) and CD56(+)) between lesional, nonlesional and healthy skin. Perforin expression was significantly upregulated in the epidermis of lichen planus lesions. In conclusion, accumulation of perforin(+) cells in the epidermis of lichen planus lesions suggest a potential role of perforin in the apoptosis of basal keratinocytes.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>15452725</pmid><doi>10.1007/s00403-004-0512-1</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Apoptosis Biological and medical sciences Dermatology Dermis - metabolism Dermis - pathology Epidermis - metabolism Epidermis - pathology Humans Immunohistochemistry Killer Cells, Natural - pathology Lichen Planus - metabolism Lichen Planus - pathology Lichen Planus - physiopathology Medical sciences Membrane Glycoproteins - metabolism Middle Aged Perforin Pore Forming Cytotoxic Proteins Psoriasis. Parapsoriasis. Lichen Skin - metabolism Skin - pathology T-Lymphocyte Subsets - pathology |
| title | The role of perforin-mediated apoptosis in lichen planus lesions |
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