Angiogenic synergy of bFGF and VEGF is antagonized by Angiopoietin-2 in a modified in vivo Matrigel assay

A murine modification of the Matrigel chamber assay originally developed for use on rats is presented. This modified assay permits improved quantification due to subcutaneous Matrigel implants of constant shape and volume. We have quantitatively assessed the angiogenic potential of the growth factor...

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Veröffentlicht in:	Microvascular research 2004-11, Vol.68 (3), p.161-168
Hauptverfasser:	Ley, Carsten D., Olsen, Minna W.B., Lund, Eva L., Kristjansen, Paul E.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ang-2 Angiogenesis Angiopoietin-2 - physiology Animals bFGF Cell Movement Cells, Cultured Chemotaxis Collagen - pharmacology Dose-Response Relationship, Drug Drug Combinations Endothelial Cells - cytology Endothelium, Vascular - cytology Fibroblast Growth Factor 2 - physiology Growth Substances Humans Image Processing, Computer-Assisted Laminin - pharmacology Male Matrigel Mice Migration Neovascularization, Pathologic Proteoglycans - pharmacology Recombinant Proteins - chemistry Signal Transduction Synergy Time Factors Vascular Endothelial Growth Factor A - physiology VEGF
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