Soft Hydrogels from Nanotubes of Poly(ethylene oxide)−Tetraphenylalanine Conjugates Prepared by Click Chemistry
A new poly(ethylene oxide)−tetraphenylalanine polymer−peptide conjugate has been prepared via a “click” reaction between an alkyne-modified peptide and an azide-terminated PEO oligomer. Self-assembled nanotubes are formed after dialysis of a THF solution of this polymer−peptide conjugate against wat...
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| Veröffentlicht in: | Langmuir 2009-02, Vol.25 (4), p.2479-2485 |
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| creator | Tzokova, Nadia Fernyhough, Christine M Topham, Paul D Sandon, Nicolas Adams, Dave J Butler, Michael F Armes, Steven P Ryan, Anthony J |
| description | A new poly(ethylene oxide)−tetraphenylalanine polymer−peptide conjugate has been prepared via a “click” reaction between an alkyne-modified peptide and an azide-terminated PEO oligomer. Self-assembled nanotubes are formed after dialysis of a THF solution of this polymer−peptide conjugate against water. The structure of these nanotubes has been probed by circular dichroism, IR, TEM, and SAXS. From these data, it is apparent that self-assembly involves the formation of antiparallel β-sheets and π−π-stacking. Nanotubes are formed at concentrations between 2 and 10 mg mL−1. Entanglement between adjacent nanotubes occurs at higher concentrations, resulting in the formation of soft hydrogels. Gel strength increases at higher polymer−peptide conjugate concentration, as expected. |
| doi_str_mv | 10.1021/la8035659 |
| format | Article |
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Self-assembled nanotubes are formed after dialysis of a THF solution of this polymer−peptide conjugate against water. The structure of these nanotubes has been probed by circular dichroism, IR, TEM, and SAXS. From these data, it is apparent that self-assembly involves the formation of antiparallel β-sheets and π−π-stacking. Nanotubes are formed at concentrations between 2 and 10 mg mL−1. Entanglement between adjacent nanotubes occurs at higher concentrations, resulting in the formation of soft hydrogels. Gel strength increases at higher polymer−peptide conjugate concentration, as expected.</description><identifier>ISSN: 0743-7463</identifier><identifier>EISSN: 1520-5827</identifier><identifier>DOI: 10.1021/la8035659</identifier><identifier>PMID: 19161273</identifier><identifier>CODEN: LANGD5</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Chemistry ; Circular Dichroism ; Colloidal gels. 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Self-assembled nanotubes are formed after dialysis of a THF solution of this polymer−peptide conjugate against water. The structure of these nanotubes has been probed by circular dichroism, IR, TEM, and SAXS. From these data, it is apparent that self-assembly involves the formation of antiparallel β-sheets and π−π-stacking. Nanotubes are formed at concentrations between 2 and 10 mg mL−1. Entanglement between adjacent nanotubes occurs at higher concentrations, resulting in the formation of soft hydrogels. Gel strength increases at higher polymer−peptide conjugate concentration, as expected.</description><subject>Chemistry</subject><subject>Circular Dichroism</subject><subject>Colloidal gels. Colloidal sols</subject><subject>Colloidal state and disperse state</subject><subject>Exact sciences and technology</subject><subject>General and physical chemistry</subject><subject>Hydrogels - chemistry</subject><subject>Materials: Nano-and Mesostructured Materials, Polymers, Gels, Liquid Crystals, Composites</subject><subject>Microscopy, Electron, Transmission</subject><subject>Molecular Structure</subject><subject>Nanotubes - chemistry</subject><subject>Nanotubes - ultrastructure</subject><subject>Phenylalanine - chemistry</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Rheology</subject><subject>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization</subject><subject>Spectrum Analysis</subject><subject>Surface physical chemistry</subject><issn>0743-7463</issn><issn>1520-5827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEtOwzAQhi0EgvJYcAHkDYguAn4lTpYo4iVVgASsI8eZtCluXOxEIjdgzRE5CUat6IbVLOabf2Y-hI4puaCE0UujUsLjJM620IjGjERxyuQ2GhEpeCRFwvfQvvdzQkjGRbaL9mhGE8okH6H3Z1t3-G6onJ2C8bh2doEfVGu7vgSPbY2frBnOoZsNBlrA9qOpYPz9-fUCnVPLGbSDUUa1Tejltp33U9WFuScHS-WgwuWAc9PoN5zPYNH4zg2HaKdWxsPRuh6g15vrl_wumjze3udXk0hxwbuI0ZpRXVZQlTpTpdQMKsEYByFlyQFUKgklIBNJ44TS8HGaCAI1QMVYIjk_QGer3KWz7z34rgj7NZhwLNjeF4kkRKQsC-B4BWpnvXdQF0vXLJQbCkqKX7_Fn9_AnqxD-3IB1YZcCw3A6RpQXitTO9Xqxv9xjFJBWBxvOKV9Mbe9a4OLfxb-AOK6kCk</recordid><startdate>20090217</startdate><enddate>20090217</enddate><creator>Tzokova, Nadia</creator><creator>Fernyhough, Christine M</creator><creator>Topham, Paul D</creator><creator>Sandon, Nicolas</creator><creator>Adams, Dave J</creator><creator>Butler, Michael F</creator><creator>Armes, Steven P</creator><creator>Ryan, Anthony J</creator><general>American Chemical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090217</creationdate><title>Soft Hydrogels from Nanotubes of Poly(ethylene oxide)−Tetraphenylalanine Conjugates Prepared by Click Chemistry</title><author>Tzokova, Nadia ; Fernyhough, Christine M ; Topham, Paul D ; Sandon, Nicolas ; Adams, Dave J ; Butler, Michael F ; Armes, Steven P ; Ryan, Anthony J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a343t-21f21cbdedbc9ab7c2ed4223e477b3eea87010e767156115828640efeed226733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Chemistry</topic><topic>Circular Dichroism</topic><topic>Colloidal gels. 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Self-assembled nanotubes are formed after dialysis of a THF solution of this polymer−peptide conjugate against water. The structure of these nanotubes has been probed by circular dichroism, IR, TEM, and SAXS. From these data, it is apparent that self-assembly involves the formation of antiparallel β-sheets and π−π-stacking. Nanotubes are formed at concentrations between 2 and 10 mg mL−1. Entanglement between adjacent nanotubes occurs at higher concentrations, resulting in the formation of soft hydrogels. Gel strength increases at higher polymer−peptide conjugate concentration, as expected.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>19161273</pmid><doi>10.1021/la8035659</doi><tpages>7</tpages></addata></record> |
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| subjects | Chemistry Circular Dichroism Colloidal gels. Colloidal sols Colloidal state and disperse state Exact sciences and technology General and physical chemistry Hydrogels - chemistry Materials: Nano-and Mesostructured Materials, Polymers, Gels, Liquid Crystals, Composites Microscopy, Electron, Transmission Molecular Structure Nanotubes - chemistry Nanotubes - ultrastructure Phenylalanine - chemistry Polyethylene Glycols - chemistry Rheology Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Spectrum Analysis Surface physical chemistry |
| title | Soft Hydrogels from Nanotubes of Poly(ethylene oxide)−Tetraphenylalanine Conjugates Prepared by Click Chemistry |
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