Investigation of the synthetic route to pepstatin analogues by SPPS using O-protected and O-unprotected statine as building blocks

The synthetic route to pepstatin derivatives by a solid phase peptide synthesis using either O‐protected or O‐unprotected statine as a building block has been investigated. Statine was prepared according to a modified literature procedure, whereas protection of its 3‐hydroxyl moiety using tert‐butyl...

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Veröffentlicht in:	Journal of peptide science 2009-04, Vol.15 (4), p.272-277
Hauptverfasser:	Cadicamo, Cosimo D., Asante, Vivian, Abu Ammar, Morhaf, Borelli, Claudia, Korting, Hans C., Koksch, Beate
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acids - chemical synthesis Amino Acids - chemistry Chromatography, High Pressure Liquid Fluorenes - chemical synthesis Fluorenes - chemistry Indicators and Reagents Magnetic Resonance Spectroscopy Molecular Structure N-Fmoc-O-TBS-statine O-silylation pepstatin A Pepstatins - chemical synthesis Pepstatins - chemistry SPPS
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