Particle size control of poly( dl-lactide-co-glycolide) nanospheres for sterile applications
Parameters affecting the particle sizes of poly(DL-lactide-co-glycolide) (PLGA) nanospheres produced by the Emulsion Solvent Diffusion (ESD) method were evaluated in this study, so that suitable PLGA nanospheres could be prepared to pass through a membrane filter with 0.2 μm pore size and used as a...
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| Veröffentlicht in: | International journal of pharmaceutics 2009-03, Vol.370 (1), p.196-201 |
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| container_title | International journal of pharmaceutics |
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| creator | Tsukada, Yusuke Hara, Kaori Bando, Yohei Huang, C.C. Kousaka, Yasuo Kawashima, Yoshiaki Morishita, Ryuichi Tsujimoto, Hiroyuki |
| description | Parameters affecting the particle sizes of poly(DL-lactide-co-glycolide) (PLGA) nanospheres produced by the Emulsion Solvent Diffusion (ESD) method were evaluated in this study, so that suitable PLGA nanospheres could be prepared to pass through a membrane filter with 0.2
μm pore size and used as a sterile product. Experimental results demonstrated that the particle sizes of PLGA nanospheres could be reduced by the following efforts.
(1)
Increase stirring rate of poor solvent.
(2)
Decrease feed rate of good solvent.
(3)
Increase poor solvent ratio.
(4)
Increase the temperature of poor solvent.
(5)
Decrease polyvinyl alcohol concentration in poor solvent.
(6)
Increase ethanol concentration in good solvent.
(7)
Decrease PLGA concentration in good solvent.
After optimization, PLGA nanospheres with a mean particle size of 102–163
nm and the 100–98% of filtration fraction could be produced and passed the bacteria challenge tests. This study found PLGA nanospheres can be efficiently prepared as a sterile product. |
| doi_str_mv | 10.1016/j.ijpharm.2008.11.019 |
| format | Article |
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μm pore size and used as a sterile product. Experimental results demonstrated that the particle sizes of PLGA nanospheres could be reduced by the following efforts.
(1)
Increase stirring rate of poor solvent.
(2)
Decrease feed rate of good solvent.
(3)
Increase poor solvent ratio.
(4)
Increase the temperature of poor solvent.
(5)
Decrease polyvinyl alcohol concentration in poor solvent.
(6)
Increase ethanol concentration in good solvent.
(7)
Decrease PLGA concentration in good solvent.
After optimization, PLGA nanospheres with a mean particle size of 102–163
nm and the 100–98% of filtration fraction could be produced and passed the bacteria challenge tests. This study found PLGA nanospheres can be efficiently prepared as a sterile product.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2008.11.019</identifier><identifier>PMID: 19100320</identifier><identifier>CODEN: IJPHDE</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Biological and medical sciences ; Diffusion ; Drug Compounding ; Drug delivery system ; Drug Delivery Systems - methods ; Emulsions ; ESD method ; Filtration ; General pharmacology ; Lactic Acid - chemistry ; Medical sciences ; Membranes, Artificial ; Nanospheres ; Particle Size ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; PLGA nanospheres ; Polyglycolic Acid - chemistry ; Pressure ; Pressure filtration ; Solvents ; Sterilization ; Surface Properties</subject><ispartof>International journal of pharmaceutics, 2009-03, Vol.370 (1), p.196-201</ispartof><rights>2008 Elsevier B.V.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-c8a97b3f808543ebb721461b6f49326bafaeac53b95029e21455fe3ba09173e43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378517308007904$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21274206$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19100320$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsukada, Yusuke</creatorcontrib><creatorcontrib>Hara, Kaori</creatorcontrib><creatorcontrib>Bando, Yohei</creatorcontrib><creatorcontrib>Huang, C.C.</creatorcontrib><creatorcontrib>Kousaka, Yasuo</creatorcontrib><creatorcontrib>Kawashima, Yoshiaki</creatorcontrib><creatorcontrib>Morishita, Ryuichi</creatorcontrib><creatorcontrib>Tsujimoto, Hiroyuki</creatorcontrib><title>Particle size control of poly( dl-lactide-co-glycolide) nanospheres for sterile applications</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>Parameters affecting the particle sizes of poly(DL-lactide-co-glycolide) (PLGA) nanospheres produced by the Emulsion Solvent Diffusion (ESD) method were evaluated in this study, so that suitable PLGA nanospheres could be prepared to pass through a membrane filter with 0.2
μm pore size and used as a sterile product. Experimental results demonstrated that the particle sizes of PLGA nanospheres could be reduced by the following efforts.
(1)
Increase stirring rate of poor solvent.
(2)
Decrease feed rate of good solvent.
(3)
Increase poor solvent ratio.
(4)
Increase the temperature of poor solvent.
(5)
Decrease polyvinyl alcohol concentration in poor solvent.
(6)
Increase ethanol concentration in good solvent.
(7)
Decrease PLGA concentration in good solvent.
After optimization, PLGA nanospheres with a mean particle size of 102–163
nm and the 100–98% of filtration fraction could be produced and passed the bacteria challenge tests. This study found PLGA nanospheres can be efficiently prepared as a sterile product.</description><subject>Biological and medical sciences</subject><subject>Diffusion</subject><subject>Drug Compounding</subject><subject>Drug delivery system</subject><subject>Drug Delivery Systems - methods</subject><subject>Emulsions</subject><subject>ESD method</subject><subject>Filtration</subject><subject>General pharmacology</subject><subject>Lactic Acid - chemistry</subject><subject>Medical sciences</subject><subject>Membranes, Artificial</subject><subject>Nanospheres</subject><subject>Particle Size</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>PLGA nanospheres</subject><subject>Polyglycolic Acid - chemistry</subject><subject>Pressure</subject><subject>Pressure filtration</subject><subject>Solvents</subject><subject>Sterilization</subject><subject>Surface Properties</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEuLFDEQgIMo7rj6E5S-KHrotirpV06LLL5gQQ96E0J1uuJmyHTapEcYf729TqNHT0VRX70-IZ4iVAjYvt5Xfj_fUjpUEqCvECtAfU_ssO9UqequvS92oLq-bLBTF-JRznsAaCWqh-ICNQIoCTvx7TOlxdvARfa_uLBxWlIMRXTFHMPpZTGGMpBd_MiljeX3cLIxrMmrYqIp5vmWE-fCxVTkhZNfx9A8B29p8XHKj8UDRyHzky1eiq_v3n65_lDefHr_8frNTWnrRi-l7Ul3g3I99E2teBg6iXWLQ-tqrWQ7kCMm26hBNyA1r8WmcawGAr3-xrW6FC_Oc-cUfxw5L-bgs-UQaOJ4zKbtAGSPegWbM2hTzDmxM3PyB0ong2DutJq92bSaO60G0cCfvmfbguNw4PFf1-ZxBZ5vAGVLwSWarM9_OYmyqyW0K3d15njV8dNzMtl6niyPPrFdzBj9f075DYhzmSg</recordid><startdate>20090331</startdate><enddate>20090331</enddate><creator>Tsukada, Yusuke</creator><creator>Hara, Kaori</creator><creator>Bando, Yohei</creator><creator>Huang, C.C.</creator><creator>Kousaka, Yasuo</creator><creator>Kawashima, Yoshiaki</creator><creator>Morishita, Ryuichi</creator><creator>Tsujimoto, Hiroyuki</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090331</creationdate><title>Particle size control of poly( dl-lactide-co-glycolide) nanospheres for sterile applications</title><author>Tsukada, Yusuke ; Hara, Kaori ; Bando, Yohei ; Huang, C.C. ; Kousaka, Yasuo ; Kawashima, Yoshiaki ; Morishita, Ryuichi ; Tsujimoto, Hiroyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-c8a97b3f808543ebb721461b6f49326bafaeac53b95029e21455fe3ba09173e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Biological and medical sciences</topic><topic>Diffusion</topic><topic>Drug Compounding</topic><topic>Drug delivery system</topic><topic>Drug Delivery Systems - methods</topic><topic>Emulsions</topic><topic>ESD method</topic><topic>Filtration</topic><topic>General pharmacology</topic><topic>Lactic Acid - chemistry</topic><topic>Medical sciences</topic><topic>Membranes, Artificial</topic><topic>Nanospheres</topic><topic>Particle Size</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>PLGA nanospheres</topic><topic>Polyglycolic Acid - chemistry</topic><topic>Pressure</topic><topic>Pressure filtration</topic><topic>Solvents</topic><topic>Sterilization</topic><topic>Surface Properties</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsukada, Yusuke</creatorcontrib><creatorcontrib>Hara, Kaori</creatorcontrib><creatorcontrib>Bando, Yohei</creatorcontrib><creatorcontrib>Huang, C.C.</creatorcontrib><creatorcontrib>Kousaka, Yasuo</creatorcontrib><creatorcontrib>Kawashima, Yoshiaki</creatorcontrib><creatorcontrib>Morishita, Ryuichi</creatorcontrib><creatorcontrib>Tsujimoto, Hiroyuki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsukada, Yusuke</au><au>Hara, Kaori</au><au>Bando, Yohei</au><au>Huang, C.C.</au><au>Kousaka, Yasuo</au><au>Kawashima, Yoshiaki</au><au>Morishita, Ryuichi</au><au>Tsujimoto, Hiroyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Particle size control of poly( dl-lactide-co-glycolide) nanospheres for sterile applications</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2009-03-31</date><risdate>2009</risdate><volume>370</volume><issue>1</issue><spage>196</spage><epage>201</epage><pages>196-201</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><coden>IJPHDE</coden><abstract>Parameters affecting the particle sizes of poly(DL-lactide-co-glycolide) (PLGA) nanospheres produced by the Emulsion Solvent Diffusion (ESD) method were evaluated in this study, so that suitable PLGA nanospheres could be prepared to pass through a membrane filter with 0.2
μm pore size and used as a sterile product. Experimental results demonstrated that the particle sizes of PLGA nanospheres could be reduced by the following efforts.
(1)
Increase stirring rate of poor solvent.
(2)
Decrease feed rate of good solvent.
(3)
Increase poor solvent ratio.
(4)
Increase the temperature of poor solvent.
(5)
Decrease polyvinyl alcohol concentration in poor solvent.
(6)
Increase ethanol concentration in good solvent.
(7)
Decrease PLGA concentration in good solvent.
After optimization, PLGA nanospheres with a mean particle size of 102–163
nm and the 100–98% of filtration fraction could be produced and passed the bacteria challenge tests. This study found PLGA nanospheres can be efficiently prepared as a sterile product.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>19100320</pmid><doi>10.1016/j.ijpharm.2008.11.019</doi><tpages>6</tpages></addata></record> |
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| subjects | Biological and medical sciences Diffusion Drug Compounding Drug delivery system Drug Delivery Systems - methods Emulsions ESD method Filtration General pharmacology Lactic Acid - chemistry Medical sciences Membranes, Artificial Nanospheres Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments PLGA nanospheres Polyglycolic Acid - chemistry Pressure Pressure filtration Solvents Sterilization Surface Properties |
| title | Particle size control of poly( dl-lactide-co-glycolide) nanospheres for sterile applications |
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