Regulation of Aldosterone Secretion by Several Aberrant Receptors Including for Glucose-Dependent Insulinotropic Peptide in a Patient with an Aldosteronoma
Context: Primary adrenal Cushing’s syndrome can result from the aberrant adrenal expression of several hormone receptors; this mechanism has not been explored in detail in aldosterone-producing tumors. Objective: The objective of the study was to evaluate a 56-yr-old male patient with an aldosterono...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2009-03, Vol.94 (3), p.750-756 |
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| creator | Lampron, Antoine Bourdeau, Isabelle Oble, Sylvie Godbout, Ariane Schürch, Walter Arjane, Philippe Hamet, Pavel Lacroix, André |
| description | Context: Primary adrenal Cushing’s syndrome can result from the aberrant adrenal expression of several hormone receptors; this mechanism has not been explored in detail in aldosterone-producing tumors.
Objective: The objective of the study was to evaluate a 56-yr-old male patient with an aldosteronoma for the regulation of aldosterone secretion by aberrant hormone receptors.
Results: Renin-independent stimulation of aldosterone secretion was observed in vivo after a mixed meal, oral glucose, or administration of glucose-dependent insulinotropic peptide (GIP), vasopressin, and tegaserod. The mixed meal-mediated stimulation of aldosterone was not present in five other cases of aldosteronoma. A smaller response of aldosterone after GIP infusion was observed in a normal subject. Aldosterone secretion was stimulated by GIP in primary cultures of this patient’s aldosteronoma. Increased expression of GIP receptor was found in this aldosteronoma by real-time RT-PCR and immunohistochemistry. The GIP receptor protein was also found at lower levels in zona glomerulosa cells of the normal adjacent adrenal gland. Increased expression of serotonin 4 and ACTH receptors was also present in this aldosteronoma.
Conclusions: This case report provides new evidence of the implication of aberrant hormone receptors in the regulation of this aldosteronoma and suggests that further detailed studies of the role of aberrant hormone receptors in this frequent pathology should be undertaken.
New evidence implicates several aberrant hormone receptors in the regulation of aldosterone production in primary aldosteronism. |
| doi_str_mv | 10.1210/jc.2008-1340 |
| format | Article |
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Objective: The objective of the study was to evaluate a 56-yr-old male patient with an aldosteronoma for the regulation of aldosterone secretion by aberrant hormone receptors.
Results: Renin-independent stimulation of aldosterone secretion was observed in vivo after a mixed meal, oral glucose, or administration of glucose-dependent insulinotropic peptide (GIP), vasopressin, and tegaserod. The mixed meal-mediated stimulation of aldosterone was not present in five other cases of aldosteronoma. A smaller response of aldosterone after GIP infusion was observed in a normal subject. Aldosterone secretion was stimulated by GIP in primary cultures of this patient’s aldosteronoma. Increased expression of GIP receptor was found in this aldosteronoma by real-time RT-PCR and immunohistochemistry. The GIP receptor protein was also found at lower levels in zona glomerulosa cells of the normal adjacent adrenal gland. Increased expression of serotonin 4 and ACTH receptors was also present in this aldosteronoma.
Conclusions: This case report provides new evidence of the implication of aberrant hormone receptors in the regulation of this aldosteronoma and suggests that further detailed studies of the role of aberrant hormone receptors in this frequent pathology should be undertaken.
New evidence implicates several aberrant hormone receptors in the regulation of aldosterone production in primary aldosteronism.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2008-1340</identifier><identifier>PMID: 19066304</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Adrenal Cortex Neoplasms - secretion ; Adrenocortical Adenoma - secretion ; Adrenocorticotropic Hormone - pharmacology ; Aldosterone - secretion ; Biological and medical sciences ; Endocrinopathies ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; Gastric Inhibitory Polypeptide - pharmacology ; Humans ; Male ; Medical sciences ; Middle Aged ; Receptors, Corticotropin - physiology ; Receptors, Gastrointestinal Hormone - analysis ; Receptors, Gastrointestinal Hormone - physiology ; Receptors, Serotonin, 5-HT4 - physiology ; Receptors, Vasopressin - physiology ; Reverse Transcriptase Polymerase Chain Reaction ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology</subject><ispartof>The journal of clinical endocrinology and metabolism, 2009-03, Vol.94 (3), p.750-756</ispartof><rights>Copyright © 2009 by The Endocrine Society</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4466-fa215f243764f6dba3951fb2a6a24644d7d0c2e3eb3a12cfcf604999ebd82f283</citedby><cites>FETCH-LOGICAL-c4466-fa215f243764f6dba3951fb2a6a24644d7d0c2e3eb3a12cfcf604999ebd82f283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21247207$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19066304$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lampron, Antoine</creatorcontrib><creatorcontrib>Bourdeau, Isabelle</creatorcontrib><creatorcontrib>Oble, Sylvie</creatorcontrib><creatorcontrib>Godbout, Ariane</creatorcontrib><creatorcontrib>Schürch, Walter</creatorcontrib><creatorcontrib>Arjane, Philippe</creatorcontrib><creatorcontrib>Hamet, Pavel</creatorcontrib><creatorcontrib>Lacroix, André</creatorcontrib><title>Regulation of Aldosterone Secretion by Several Aberrant Receptors Including for Glucose-Dependent Insulinotropic Peptide in a Patient with an Aldosteronoma</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Context: Primary adrenal Cushing’s syndrome can result from the aberrant adrenal expression of several hormone receptors; this mechanism has not been explored in detail in aldosterone-producing tumors.
Objective: The objective of the study was to evaluate a 56-yr-old male patient with an aldosteronoma for the regulation of aldosterone secretion by aberrant hormone receptors.
Results: Renin-independent stimulation of aldosterone secretion was observed in vivo after a mixed meal, oral glucose, or administration of glucose-dependent insulinotropic peptide (GIP), vasopressin, and tegaserod. The mixed meal-mediated stimulation of aldosterone was not present in five other cases of aldosteronoma. A smaller response of aldosterone after GIP infusion was observed in a normal subject. Aldosterone secretion was stimulated by GIP in primary cultures of this patient’s aldosteronoma. Increased expression of GIP receptor was found in this aldosteronoma by real-time RT-PCR and immunohistochemistry. The GIP receptor protein was also found at lower levels in zona glomerulosa cells of the normal adjacent adrenal gland. Increased expression of serotonin 4 and ACTH receptors was also present in this aldosteronoma.
Conclusions: This case report provides new evidence of the implication of aberrant hormone receptors in the regulation of this aldosteronoma and suggests that further detailed studies of the role of aberrant hormone receptors in this frequent pathology should be undertaken.
New evidence implicates several aberrant hormone receptors in the regulation of aldosterone production in primary aldosteronism.</description><subject>Adrenal Cortex Neoplasms - secretion</subject><subject>Adrenocortical Adenoma - secretion</subject><subject>Adrenocorticotropic Hormone - pharmacology</subject><subject>Aldosterone - secretion</subject><subject>Biological and medical sciences</subject><subject>Endocrinopathies</subject><subject>Feeding. Feeding behavior</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastric Inhibitory Polypeptide - pharmacology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Receptors, Corticotropin - physiology</subject><subject>Receptors, Gastrointestinal Hormone - analysis</subject><subject>Receptors, Gastrointestinal Hormone - physiology</subject><subject>Receptors, Serotonin, 5-HT4 - physiology</subject><subject>Receptors, Vasopressin - physiology</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vertebrates: endocrinology</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkU9vEzEQxS0EoqFw44x8gRNb_C_e7DEqUCJVoiogcbO83nHj4NiLvSbqZ-HL4iURcMAXa8a_mWe9h9BzSi4oo-TNzlwwQlYN5YI8QAvaiWXT0q59iBaEMNp0Lft6hp7kvCOECrHkj9EZ7YiUnIgF-nkLd8XrycWAo8VrP8Q8QYoB8CcwCX4_9Pe1-AFJe7zuISUdJnwLBsYppow3wfgyuHCHbUz4yhcTMzRvYYQwQCU3IRfvQpxSHJ3BN3XMDYBdwBrfVOWZObhpi3X4Rz_u9VP0yGqf4dnpPkdf3r_7fPmhuf54tblcXzdGCCkbqxldWiZ4K4WVQ695t6S2Z1pqJqQQQzsQw4BDzzVlxhoriei6DvphxSxb8XP06rh3TPF7gTypvcsGvNcBYslKttVISWbw9RE0KeacwKoxub1O94oSNYehdkbNYag5jIq_OO0t_R6Gv_DJ_Qq8PAE6G-1tNda4_IdjlImWkbZy4sgdoq_m5G--HCCpLWg_bRWpR8h21VTljvBaNXNL1jF-HKtBRJNcgDFBzmoXSwrV0P__-hfTS7Wt</recordid><startdate>200903</startdate><enddate>200903</enddate><creator>Lampron, Antoine</creator><creator>Bourdeau, Isabelle</creator><creator>Oble, Sylvie</creator><creator>Godbout, Ariane</creator><creator>Schürch, Walter</creator><creator>Arjane, Philippe</creator><creator>Hamet, Pavel</creator><creator>Lacroix, André</creator><general>Endocrine Society</general><general>Copyright by The Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200903</creationdate><title>Regulation of Aldosterone Secretion by Several Aberrant Receptors Including for Glucose-Dependent Insulinotropic Peptide in a Patient with an Aldosteronoma</title><author>Lampron, Antoine ; Bourdeau, Isabelle ; Oble, Sylvie ; Godbout, Ariane ; Schürch, Walter ; Arjane, Philippe ; Hamet, Pavel ; Lacroix, André</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4466-fa215f243764f6dba3951fb2a6a24644d7d0c2e3eb3a12cfcf604999ebd82f283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adrenal Cortex Neoplasms - secretion</topic><topic>Adrenocortical Adenoma - secretion</topic><topic>Adrenocorticotropic Hormone - pharmacology</topic><topic>Aldosterone - secretion</topic><topic>Biological and medical sciences</topic><topic>Endocrinopathies</topic><topic>Feeding. Feeding behavior</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastric Inhibitory Polypeptide - pharmacology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Receptors, Corticotropin - physiology</topic><topic>Receptors, Gastrointestinal Hormone - analysis</topic><topic>Receptors, Gastrointestinal Hormone - physiology</topic><topic>Receptors, Serotonin, 5-HT4 - physiology</topic><topic>Receptors, Vasopressin - physiology</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lampron, Antoine</creatorcontrib><creatorcontrib>Bourdeau, Isabelle</creatorcontrib><creatorcontrib>Oble, Sylvie</creatorcontrib><creatorcontrib>Godbout, Ariane</creatorcontrib><creatorcontrib>Schürch, Walter</creatorcontrib><creatorcontrib>Arjane, Philippe</creatorcontrib><creatorcontrib>Hamet, Pavel</creatorcontrib><creatorcontrib>Lacroix, André</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lampron, Antoine</au><au>Bourdeau, Isabelle</au><au>Oble, Sylvie</au><au>Godbout, Ariane</au><au>Schürch, Walter</au><au>Arjane, Philippe</au><au>Hamet, Pavel</au><au>Lacroix, André</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation of Aldosterone Secretion by Several Aberrant Receptors Including for Glucose-Dependent Insulinotropic Peptide in a Patient with an Aldosteronoma</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2009-03</date><risdate>2009</risdate><volume>94</volume><issue>3</issue><spage>750</spage><epage>756</epage><pages>750-756</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>Context: Primary adrenal Cushing’s syndrome can result from the aberrant adrenal expression of several hormone receptors; this mechanism has not been explored in detail in aldosterone-producing tumors.
Objective: The objective of the study was to evaluate a 56-yr-old male patient with an aldosteronoma for the regulation of aldosterone secretion by aberrant hormone receptors.
Results: Renin-independent stimulation of aldosterone secretion was observed in vivo after a mixed meal, oral glucose, or administration of glucose-dependent insulinotropic peptide (GIP), vasopressin, and tegaserod. The mixed meal-mediated stimulation of aldosterone was not present in five other cases of aldosteronoma. A smaller response of aldosterone after GIP infusion was observed in a normal subject. Aldosterone secretion was stimulated by GIP in primary cultures of this patient’s aldosteronoma. Increased expression of GIP receptor was found in this aldosteronoma by real-time RT-PCR and immunohistochemistry. The GIP receptor protein was also found at lower levels in zona glomerulosa cells of the normal adjacent adrenal gland. Increased expression of serotonin 4 and ACTH receptors was also present in this aldosteronoma.
Conclusions: This case report provides new evidence of the implication of aberrant hormone receptors in the regulation of this aldosteronoma and suggests that further detailed studies of the role of aberrant hormone receptors in this frequent pathology should be undertaken.
New evidence implicates several aberrant hormone receptors in the regulation of aldosterone production in primary aldosteronism.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>19066304</pmid><doi>10.1210/jc.2008-1340</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0021-972X |
| ispartof | The journal of clinical endocrinology and metabolism, 2009-03, Vol.94 (3), p.750-756 |
| issn | 0021-972X 1945-7197 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adrenal Cortex Neoplasms - secretion Adrenocortical Adenoma - secretion Adrenocorticotropic Hormone - pharmacology Aldosterone - secretion Biological and medical sciences Endocrinopathies Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Gastric Inhibitory Polypeptide - pharmacology Humans Male Medical sciences Middle Aged Receptors, Corticotropin - physiology Receptors, Gastrointestinal Hormone - analysis Receptors, Gastrointestinal Hormone - physiology Receptors, Serotonin, 5-HT4 - physiology Receptors, Vasopressin - physiology Reverse Transcriptase Polymerase Chain Reaction Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology |
| title | Regulation of Aldosterone Secretion by Several Aberrant Receptors Including for Glucose-Dependent Insulinotropic Peptide in a Patient with an Aldosteronoma |
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