Expression of the GATA-4 and GATA-6 transcription factors in the fetal rat gonad and in the ovary during postnatal development and pregnancy
Immunohistochemical studies were undertaken to determine the distribution of GATA-4 and GATA-6 in rat fetal gonad and the postnatal ovary during development and pregnancy. In the undifferentiated gonad, GATA-4 was expressed in the somatic cells of both sexes. After differentiation of the ovary and t...
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| Veröffentlicht in: | Molecular and cellular endocrinology 2004-11, Vol.227 (1), p.31-40 |
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| creator | LaVoie, Holly A. McCoy, George L. Blake, Charles A. |
| description | Immunohistochemical studies were undertaken to determine the distribution of GATA-4 and GATA-6 in rat fetal gonad and the postnatal ovary during development and pregnancy. In the undifferentiated gonad, GATA-4 was expressed in the somatic cells of both sexes. After differentiation of the ovary and testis, GATA-4 expression continued in both ovarian and testicular somatic cells; whereas, GATA-6 was expressed in both somatic and germ cells. In the ovary of postnatal rats, granulosa and thecal cells of healthy follicles expressed both GATA factors. In the adult rat, GATA-4 expression was lower in corpora lutea as compared to follicles; whereas, GATA-6 was strongly expressed in both structures. GATA-4 expression was greater in functional corpora lutea than regressing corpora lutea. GATA-6 was expressed in both functional and regressing corpora lutea. In all postnatal ovaries, the expression of P450scc localized with tissue expressing GATA-4 and/or GATA-6, but GATA expression also occurred in P450scc negative cells. |
| doi_str_mv | 10.1016/j.mce.2004.07.016 |
| format | Article |
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In the undifferentiated gonad, GATA-4 was expressed in the somatic cells of both sexes. After differentiation of the ovary and testis, GATA-4 expression continued in both ovarian and testicular somatic cells; whereas, GATA-6 was expressed in both somatic and germ cells. In the ovary of postnatal rats, granulosa and thecal cells of healthy follicles expressed both GATA factors. In the adult rat, GATA-4 expression was lower in corpora lutea as compared to follicles; whereas, GATA-6 was strongly expressed in both structures. GATA-4 expression was greater in functional corpora lutea than regressing corpora lutea. GATA-6 was expressed in both functional and regressing corpora lutea. In all postnatal ovaries, the expression of P450scc localized with tissue expressing GATA-4 and/or GATA-6, but GATA expression also occurred in P450scc negative cells.</description><subject>Animals</subject><subject>Cell Differentiation</subject><subject>Cholesterol Side-Chain Cleavage Enzyme - metabolism</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Female</subject><subject>GATA-4</subject><subject>GATA-6</subject><subject>GATA4 Transcription Factor</subject><subject>GATA6 Transcription Factor</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Genital ridge</subject><subject>Gonad</subject><subject>Male</subject><subject>Ovary</subject><subject>Ovary - embryology</subject><subject>Ovary - growth & development</subject><subject>Ovary - metabolism</subject><subject>P450scc</subject><subject>Pregnancy</subject><subject>Rats</subject><subject>Testis</subject><subject>Testis - embryology</subject><subject>Testis - growth & development</subject><subject>Testis - metabolism</subject><subject>Transcription Factors - metabolism</subject><subject>Zinc Fingers</subject><issn>0303-7207</issn><issn>1872-8057</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9uEzEQxi0EoqHwAFyQT9x2GW92bUecoqqUSpW4lLPltcfBUdZebCei79CHxvkjcaOnGY1_36fxfIR8ZNAyYPzLtp0Mth1A34Jo6-QVWTApukbCIF6TBSxh2YgOxBV5l_MWAMTQybfkig0DsEF2C_J8-2dOmLOPgUZHyy-kd-vHddNTHey55bQkHbJJfi5HzGlTYsrUhxPusOgdTbrQTQzannSXp3jQ6YnaffJhQ-eYS9BH1uIBd3GeMJQTXRfYBB3M03vyxuldxg-Xek1-frt9vPnePPy4u79ZPzSm73lpOiG4YA6N6TmsgEvpOAy9Y3LkIxuFsCNIFKMZtexQMs4dW9pu5ax2wmm3vCafz75zir_3mIuafDa42-mAcZ8VFwAdsNWLIFv1rJ4XKsjOoEkx54ROzclP9feKgTpmpbaqZqWOWSkQqk6q5tPFfD9OaP8pLuFU4OsZwHqLg8eksvEYDFqf0BRlo_-P_V-doqVT</recordid><startdate>20041130</startdate><enddate>20041130</enddate><creator>LaVoie, Holly A.</creator><creator>McCoy, George L.</creator><creator>Blake, Charles A.</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>20041130</creationdate><title>Expression of the GATA-4 and GATA-6 transcription factors in the fetal rat gonad and in the ovary during postnatal development and pregnancy</title><author>LaVoie, Holly A. ; McCoy, George L. ; Blake, Charles A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-277671fecc46090688f6054f18b6b1b77db08e7bcba82e8166f13d29fdaf7faf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Cell Differentiation</topic><topic>Cholesterol Side-Chain Cleavage Enzyme - metabolism</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Female</topic><topic>GATA-4</topic><topic>GATA-6</topic><topic>GATA4 Transcription Factor</topic><topic>GATA6 Transcription Factor</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Genital ridge</topic><topic>Gonad</topic><topic>Male</topic><topic>Ovary</topic><topic>Ovary - embryology</topic><topic>Ovary - growth & development</topic><topic>Ovary - metabolism</topic><topic>P450scc</topic><topic>Pregnancy</topic><topic>Rats</topic><topic>Testis</topic><topic>Testis - embryology</topic><topic>Testis - growth & development</topic><topic>Testis - metabolism</topic><topic>Transcription Factors - metabolism</topic><topic>Zinc Fingers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LaVoie, Holly A.</creatorcontrib><creatorcontrib>McCoy, George L.</creatorcontrib><creatorcontrib>Blake, Charles A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular and cellular endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LaVoie, Holly A.</au><au>McCoy, George L.</au><au>Blake, Charles A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of the GATA-4 and GATA-6 transcription factors in the fetal rat gonad and in the ovary during postnatal development and pregnancy</atitle><jtitle>Molecular and cellular endocrinology</jtitle><addtitle>Mol Cell Endocrinol</addtitle><date>2004-11-30</date><risdate>2004</risdate><volume>227</volume><issue>1</issue><spage>31</spage><epage>40</epage><pages>31-40</pages><issn>0303-7207</issn><eissn>1872-8057</eissn><abstract>Immunohistochemical studies were undertaken to determine the distribution of GATA-4 and GATA-6 in rat fetal gonad and the postnatal ovary during development and pregnancy. In the undifferentiated gonad, GATA-4 was expressed in the somatic cells of both sexes. After differentiation of the ovary and testis, GATA-4 expression continued in both ovarian and testicular somatic cells; whereas, GATA-6 was expressed in both somatic and germ cells. In the ovary of postnatal rats, granulosa and thecal cells of healthy follicles expressed both GATA factors. In the adult rat, GATA-4 expression was lower in corpora lutea as compared to follicles; whereas, GATA-6 was strongly expressed in both structures. GATA-4 expression was greater in functional corpora lutea than regressing corpora lutea. GATA-6 was expressed in both functional and regressing corpora lutea. In all postnatal ovaries, the expression of P450scc localized with tissue expressing GATA-4 and/or GATA-6, but GATA expression also occurred in P450scc negative cells.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>15501582</pmid><doi>10.1016/j.mce.2004.07.016</doi><tpages>10</tpages></addata></record> |
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| ispartof | Molecular and cellular endocrinology, 2004-11, Vol.227 (1), p.31-40 |
| issn | 0303-7207 1872-8057 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Cell Differentiation Cholesterol Side-Chain Cleavage Enzyme - metabolism DNA-Binding Proteins - metabolism Female GATA-4 GATA-6 GATA4 Transcription Factor GATA6 Transcription Factor Gene Expression Regulation, Developmental Genital ridge Gonad Male Ovary Ovary - embryology Ovary - growth & development Ovary - metabolism P450scc Pregnancy Rats Testis Testis - embryology Testis - growth & development Testis - metabolism Transcription Factors - metabolism Zinc Fingers |
| title | Expression of the GATA-4 and GATA-6 transcription factors in the fetal rat gonad and in the ovary during postnatal development and pregnancy |
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