Longitudinal Seroepidemiologic Study of Visceral Leishmaniasis in Hyperendemic Regions of Bihar, India
We conducted a seroepidemiologic study of visceral leishmaniasis (VL) in hyperendemic communities in Bihar, India, to determine its seroprevalence. A direct agglutination test (DAT) and rK39 antigen strip test were used as serologic tests. Capillary blood samples were collected on filter papers from...
Gespeichert in:
| Veröffentlicht in: | The American journal of tropical medicine and hygiene 2009-03, Vol.80 (3), p.345-346 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 346 |
|---|---|
| container_issue | 3 |
| container_start_page | 345 |
| container_title | The American journal of tropical medicine and hygiene |
| container_volume | 80 |
| creator | Gidwani, Kamlesh Kumar, Rajiv Rai, Madhukar Sundar, Shyam |
| description | We conducted a seroepidemiologic study of visceral leishmaniasis (VL) in hyperendemic communities in Bihar, India, to determine its seroprevalence. A direct agglutination test (DAT) and rK39 antigen strip test were used as serologic tests. Capillary blood samples were collected on filter papers from 870 healthy persons (574 and 296 from households with or without VL, respectively). Of these persons, 230 (26.43%) were positive by DAT (titer > or =1:1,600) and 120 (13.79%) were positive by the rK39 antigen strip test. During a two-year follow-up, 25 persons developed VL; 1 and 8 persons were positive by the rK39 strip test and DAT, respectively, and 1 was positive by both tests. Fifteen (2.57%) persons who were seronegative at baseline also developed VL. Disease occurred more among persons living in the same household (24 of 25). However, there was no significant difference in disease conversion among children (5-15 years of age) and adults (> 15 years of age). Seropositivity among asymptomatic persons is not a predictor for development of VL. |
| doi_str_mv | 10.4269/ajtmh.2009.80.345 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67001476</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20804530</sourcerecordid><originalsourceid>FETCH-LOGICAL-c433t-4bb4dba6423e260afd778775b5ae95e41d80feb7e44462d1e896ac63f210619d3</originalsourceid><addsrcrecordid>eNqFkUtv2zAQhImiReOk_QG5BLq0p8hZPkRKxyZoHoCBAk3aK0GJK4uBRLqkDcP_vlRiNMee9rDfzC5mCDmnsBRMNlfmeTsNSwbQLGtYclG9IwsqlCypFNV7sgAAVjaSqxNymtIzAK0ZpR_JCW2YAqaaBelXwa_ddmedN2PxiDHgxlmcXBjD2nXFY14ditAXv13qMGZmhS4Nk_HOJJcK54v7wwYj-lnUFT9x7YJPs-LaDSZeFg_eOvOJfOjNmPDzcZ6RX7ffn27uy9WPu4ebb6uyE5xvS9G2wrZGCsaRSTC9VapWqmorg02FgtoaemwVCiEksxTrRppO8p5RkLSx_Ix8ffXdxPBnh2mrp_nvcTQewy5pqXIIOaH_ggxqEBWHDNJXsIshpYi93kQ3mXjQFPTcgn5pQc8t6Bp0biFrLo7mu3ZC-6Y4xp6BL0fApM6MfTS-c-kfxyirOGPsjRvceti7iDpNZhyzLdX7_X4-93LwL6Vwnpc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20804530</pqid></control><display><type>article</type><title>Longitudinal Seroepidemiologic Study of Visceral Leishmaniasis in Hyperendemic Regions of Bihar, India</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Gidwani, Kamlesh ; Kumar, Rajiv ; Rai, Madhukar ; Sundar, Shyam</creator><creatorcontrib>Gidwani, Kamlesh ; Kumar, Rajiv ; Rai, Madhukar ; Sundar, Shyam</creatorcontrib><description>We conducted a seroepidemiologic study of visceral leishmaniasis (VL) in hyperendemic communities in Bihar, India, to determine its seroprevalence. A direct agglutination test (DAT) and rK39 antigen strip test were used as serologic tests. Capillary blood samples were collected on filter papers from 870 healthy persons (574 and 296 from households with or without VL, respectively). Of these persons, 230 (26.43%) were positive by DAT (titer > or =1:1,600) and 120 (13.79%) were positive by the rK39 antigen strip test. During a two-year follow-up, 25 persons developed VL; 1 and 8 persons were positive by the rK39 strip test and DAT, respectively, and 1 was positive by both tests. Fifteen (2.57%) persons who were seronegative at baseline also developed VL. Disease occurred more among persons living in the same household (24 of 25). However, there was no significant difference in disease conversion among children (5-15 years of age) and adults (> 15 years of age). Seropositivity among asymptomatic persons is not a predictor for development of VL.</description><identifier>ISSN: 0002-9637</identifier><identifier>EISSN: 1476-1645</identifier><identifier>DOI: 10.4269/ajtmh.2009.80.345</identifier><identifier>PMID: 19270279</identifier><identifier>CODEN: AJTHAB</identifier><language>eng</language><publisher>Deerfield, IL: ASTMH</publisher><subject>Adolescent ; Agglutination Tests ; Antibodies, Protozoan - blood ; Biological and medical sciences ; Child ; Child, Preschool ; Endemic Diseases ; Female ; Human protozoal diseases ; Humans ; India - epidemiology ; Infectious diseases ; Leishmaniasis, Visceral - epidemiology ; Leshmaniasis ; Longitudinal Studies ; Male ; Medical sciences ; Parasitic diseases ; Protozoal diseases ; Seroepidemiologic Studies</subject><ispartof>The American journal of tropical medicine and hygiene, 2009-03, Vol.80 (3), p.345-346</ispartof><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c433t-4bb4dba6423e260afd778775b5ae95e41d80feb7e44462d1e896ac63f210619d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21253222$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19270279$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gidwani, Kamlesh</creatorcontrib><creatorcontrib>Kumar, Rajiv</creatorcontrib><creatorcontrib>Rai, Madhukar</creatorcontrib><creatorcontrib>Sundar, Shyam</creatorcontrib><title>Longitudinal Seroepidemiologic Study of Visceral Leishmaniasis in Hyperendemic Regions of Bihar, India</title><title>The American journal of tropical medicine and hygiene</title><addtitle>Am J Trop Med Hyg</addtitle><description>We conducted a seroepidemiologic study of visceral leishmaniasis (VL) in hyperendemic communities in Bihar, India, to determine its seroprevalence. A direct agglutination test (DAT) and rK39 antigen strip test were used as serologic tests. Capillary blood samples were collected on filter papers from 870 healthy persons (574 and 296 from households with or without VL, respectively). Of these persons, 230 (26.43%) were positive by DAT (titer > or =1:1,600) and 120 (13.79%) were positive by the rK39 antigen strip test. During a two-year follow-up, 25 persons developed VL; 1 and 8 persons were positive by the rK39 strip test and DAT, respectively, and 1 was positive by both tests. Fifteen (2.57%) persons who were seronegative at baseline also developed VL. Disease occurred more among persons living in the same household (24 of 25). However, there was no significant difference in disease conversion among children (5-15 years of age) and adults (> 15 years of age). Seropositivity among asymptomatic persons is not a predictor for development of VL.</description><subject>Adolescent</subject><subject>Agglutination Tests</subject><subject>Antibodies, Protozoan - blood</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Endemic Diseases</subject><subject>Female</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>India - epidemiology</subject><subject>Infectious diseases</subject><subject>Leishmaniasis, Visceral - epidemiology</subject><subject>Leshmaniasis</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Parasitic diseases</subject><subject>Protozoal diseases</subject><subject>Seroepidemiologic Studies</subject><issn>0002-9637</issn><issn>1476-1645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv2zAQhImiReOk_QG5BLq0p8hZPkRKxyZoHoCBAk3aK0GJK4uBRLqkDcP_vlRiNMee9rDfzC5mCDmnsBRMNlfmeTsNSwbQLGtYclG9IwsqlCypFNV7sgAAVjaSqxNymtIzAK0ZpR_JCW2YAqaaBelXwa_ddmedN2PxiDHgxlmcXBjD2nXFY14ditAXv13qMGZmhS4Nk_HOJJcK54v7wwYj-lnUFT9x7YJPs-LaDSZeFg_eOvOJfOjNmPDzcZ6RX7ffn27uy9WPu4ebb6uyE5xvS9G2wrZGCsaRSTC9VapWqmorg02FgtoaemwVCiEksxTrRppO8p5RkLSx_Ix8ffXdxPBnh2mrp_nvcTQewy5pqXIIOaH_ggxqEBWHDNJXsIshpYi93kQ3mXjQFPTcgn5pQc8t6Bp0biFrLo7mu3ZC-6Y4xp6BL0fApM6MfTS-c-kfxyirOGPsjRvceti7iDpNZhyzLdX7_X4-93LwL6Vwnpc</recordid><startdate>20090301</startdate><enddate>20090301</enddate><creator>Gidwani, Kamlesh</creator><creator>Kumar, Rajiv</creator><creator>Rai, Madhukar</creator><creator>Sundar, Shyam</creator><general>ASTMH</general><general>American Society of Tropical Medecine and Hygiene</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20090301</creationdate><title>Longitudinal Seroepidemiologic Study of Visceral Leishmaniasis in Hyperendemic Regions of Bihar, India</title><author>Gidwani, Kamlesh ; Kumar, Rajiv ; Rai, Madhukar ; Sundar, Shyam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-4bb4dba6423e260afd778775b5ae95e41d80feb7e44462d1e896ac63f210619d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Agglutination Tests</topic><topic>Antibodies, Protozoan - blood</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Endemic Diseases</topic><topic>Female</topic><topic>Human protozoal diseases</topic><topic>Humans</topic><topic>India - epidemiology</topic><topic>Infectious diseases</topic><topic>Leishmaniasis, Visceral - epidemiology</topic><topic>Leshmaniasis</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Parasitic diseases</topic><topic>Protozoal diseases</topic><topic>Seroepidemiologic Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gidwani, Kamlesh</creatorcontrib><creatorcontrib>Kumar, Rajiv</creatorcontrib><creatorcontrib>Rai, Madhukar</creatorcontrib><creatorcontrib>Sundar, Shyam</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of tropical medicine and hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gidwani, Kamlesh</au><au>Kumar, Rajiv</au><au>Rai, Madhukar</au><au>Sundar, Shyam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal Seroepidemiologic Study of Visceral Leishmaniasis in Hyperendemic Regions of Bihar, India</atitle><jtitle>The American journal of tropical medicine and hygiene</jtitle><addtitle>Am J Trop Med Hyg</addtitle><date>2009-03-01</date><risdate>2009</risdate><volume>80</volume><issue>3</issue><spage>345</spage><epage>346</epage><pages>345-346</pages><issn>0002-9637</issn><eissn>1476-1645</eissn><coden>AJTHAB</coden><abstract>We conducted a seroepidemiologic study of visceral leishmaniasis (VL) in hyperendemic communities in Bihar, India, to determine its seroprevalence. A direct agglutination test (DAT) and rK39 antigen strip test were used as serologic tests. Capillary blood samples were collected on filter papers from 870 healthy persons (574 and 296 from households with or without VL, respectively). Of these persons, 230 (26.43%) were positive by DAT (titer > or =1:1,600) and 120 (13.79%) were positive by the rK39 antigen strip test. During a two-year follow-up, 25 persons developed VL; 1 and 8 persons were positive by the rK39 strip test and DAT, respectively, and 1 was positive by both tests. Fifteen (2.57%) persons who were seronegative at baseline also developed VL. Disease occurred more among persons living in the same household (24 of 25). However, there was no significant difference in disease conversion among children (5-15 years of age) and adults (> 15 years of age). Seropositivity among asymptomatic persons is not a predictor for development of VL.</abstract><cop>Deerfield, IL</cop><pub>ASTMH</pub><pmid>19270279</pmid><doi>10.4269/ajtmh.2009.80.345</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9637 |
| ispartof | The American journal of tropical medicine and hygiene, 2009-03, Vol.80 (3), p.345-346 |
| issn | 0002-9637 1476-1645 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67001476 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Agglutination Tests Antibodies, Protozoan - blood Biological and medical sciences Child Child, Preschool Endemic Diseases Female Human protozoal diseases Humans India - epidemiology Infectious diseases Leishmaniasis, Visceral - epidemiology Leshmaniasis Longitudinal Studies Male Medical sciences Parasitic diseases Protozoal diseases Seroepidemiologic Studies |
| title | Longitudinal Seroepidemiologic Study of Visceral Leishmaniasis in Hyperendemic Regions of Bihar, India |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T23%3A24%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Longitudinal%20Seroepidemiologic%20Study%20of%20Visceral%20Leishmaniasis%20in%20Hyperendemic%20Regions%20of%20Bihar,%20India&rft.jtitle=The%20American%20journal%20of%20tropical%20medicine%20and%20hygiene&rft.au=Gidwani,%20Kamlesh&rft.date=2009-03-01&rft.volume=80&rft.issue=3&rft.spage=345&rft.epage=346&rft.pages=345-346&rft.issn=0002-9637&rft.eissn=1476-1645&rft.coden=AJTHAB&rft_id=info:doi/10.4269/ajtmh.2009.80.345&rft_dat=%3Cproquest_cross%3E20804530%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=20804530&rft_id=info:pmid/19270279&rfr_iscdi=true |