Reduction in experimental peridural adhesion with the use of a crosslinked hyaluronate/collagen membrane
The research goals were to fabricate a crosslinked hyaluronate (HA)/collagen membrane and study its efficacy in preventing peridural adhesion. Different weight ratios of HA/collagen membranes crosslinked with carbodiimide were tested for biocompatibility and biodegradability first. Forty‐eight adult...
Gespeichert in:
| Veröffentlicht in: | Journal of biomedical materials research 2004-11, Vol.71B (2), p.421-428 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 428 |
|---|---|
| container_issue | 2 |
| container_start_page | 421 |
| container_title | Journal of biomedical materials research |
| container_volume | 71B |
| creator | Shih, Hsin-Nung Fang, Jen-Feng Chen, Jui-Hsiang Yang, Chiung-Lin Chen, Yu-Hua Sung, Tseng-Hwa Shih, Lih-Yuann |
| description | The research goals were to fabricate a crosslinked hyaluronate (HA)/collagen membrane and study its efficacy in preventing peridural adhesion. Different weight ratios of HA/collagen membranes crosslinked with carbodiimide were tested for biocompatibility and biodegradability first. Forty‐eight adult New Zealand white rabbits underwent an L6 laminectomy. Sixteen rabbits each received a weight ratio of HA/collagen = 60/40 membrane (Membrane A) or a 40/60 membrane (Membrane B) on the exposed dura. The last 16 rabbits received no treatment and served as controls. No adverse reaction of the membranes was noted. Magnetic resonance images revealed a hyposignal space between the dura and the scar tissues at Membrane B‐treated laminectomy site 3 months after surgery. Histological examination showed that the amount of scarring decreased with time in all groups. Amount of scarring decreased significantly at laminectomy sites treated with either membrane. Compared with the control group, the extent of peridural adhesion decreased significantly in the Membrane B‐treated group at 3 months after surgery; while it decreased substantially, but not significantly, in the Membrane A‐treated group. The carbodiimide‐crosslinked HA/collagen membrane is a safe and effective antiadhesive material in vivo. When placed onto the laminectomy site, the membrane with a weight ratio of HA/collagen = 40/60 appears to reduce peridural scar adhesion. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 71B: 421–428, 2004 |
| doi_str_mv | 10.1002/jbm.b.30106 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67001441</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20562962</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4276-175cd50e25155db58edb2a5f1caee9e5f8c7b271456fabef8fcabca3139e1b583</originalsourceid><addsrcrecordid>eNqFkc1PGzEQxa2KqlDoiTvyiUu1icde78exjdoASmlBqXq0bO8su7Afwd4V5L_HISnc4DTv8JunmfcIOQY2Acb49Na0EzMRDFjygRyAlDyK8wz2XnQq9sln728DnDApPpF9kCLLJcsPSHWNxWiHuu9o3VF8XKGrW-wG3dCNLEYXlC4q9BvkoR4qOlRIR4-0L6mm1vXeN3V3hwWt1roZXd_pAae2bxp9gx1tsTVOd3hEPpa68fhlNw_J358_lrOzaPF7fj77tohszNMkglTaQjLkMhxfGJlhYbiWJViNmKMsM5sankIsk1IbLLPSamO1AJEjBFwcktOt78r19yP6QbW1txiu6bAfvUpSxiCO4V2QM5nwPOHvgpCKTIo8DuDXLfgcisNSrUKY2q0VMLWpSoWqlFHPVQX6ZGc7mhaLV3bXTQBgCzzUDa7f8lIX33_9N422O7Uf8PFlR7u78LhIpfp3OVd_YAlX8-VcXYsnl5mwRA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17385394</pqid></control><display><type>article</type><title>Reduction in experimental peridural adhesion with the use of a crosslinked hyaluronate/collagen membrane</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Shih, Hsin-Nung ; Fang, Jen-Feng ; Chen, Jui-Hsiang ; Yang, Chiung-Lin ; Chen, Yu-Hua ; Sung, Tseng-Hwa ; Shih, Lih-Yuann</creator><creatorcontrib>Shih, Hsin-Nung ; Fang, Jen-Feng ; Chen, Jui-Hsiang ; Yang, Chiung-Lin ; Chen, Yu-Hua ; Sung, Tseng-Hwa ; Shih, Lih-Yuann</creatorcontrib><description>The research goals were to fabricate a crosslinked hyaluronate (HA)/collagen membrane and study its efficacy in preventing peridural adhesion. Different weight ratios of HA/collagen membranes crosslinked with carbodiimide were tested for biocompatibility and biodegradability first. Forty‐eight adult New Zealand white rabbits underwent an L6 laminectomy. Sixteen rabbits each received a weight ratio of HA/collagen = 60/40 membrane (Membrane A) or a 40/60 membrane (Membrane B) on the exposed dura. The last 16 rabbits received no treatment and served as controls. No adverse reaction of the membranes was noted. Magnetic resonance images revealed a hyposignal space between the dura and the scar tissues at Membrane B‐treated laminectomy site 3 months after surgery. Histological examination showed that the amount of scarring decreased with time in all groups. Amount of scarring decreased significantly at laminectomy sites treated with either membrane. Compared with the control group, the extent of peridural adhesion decreased significantly in the Membrane B‐treated group at 3 months after surgery; while it decreased substantially, but not significantly, in the Membrane A‐treated group. The carbodiimide‐crosslinked HA/collagen membrane is a safe and effective antiadhesive material in vivo. When placed onto the laminectomy site, the membrane with a weight ratio of HA/collagen = 40/60 appears to reduce peridural scar adhesion. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 71B: 421–428, 2004</description><identifier>ISSN: 1552-4973</identifier><identifier>ISSN: 0021-9304</identifier><identifier>EISSN: 1552-4981</identifier><identifier>DOI: 10.1002/jbm.b.30106</identifier><identifier>PMID: 15389509</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Biocompatible Materials ; Bone Regeneration - drug effects ; carbodiimide (EDC) ; Cicatrix - pathology ; Collagen - chemistry ; Cross-Linking Reagents ; crosslinking ; Epidural Space - pathology ; hyaluronic acid (HA) ; Hyaluronic Acid - chemistry ; laminectomy ; laminectomy, peridural scar adhesion ; Magnetic Resonance Imaging ; Materials Testing ; Myelography ; peridural scar adhesion ; Rabbits ; Tissue Adhesions - prevention & control</subject><ispartof>Journal of biomedical materials research, 2004-11, Vol.71B (2), p.421-428</ispartof><rights>Copyright © 2004 Wiley Periodicals, Inc.</rights><rights>(c) 2004 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4276-175cd50e25155db58edb2a5f1caee9e5f8c7b271456fabef8fcabca3139e1b583</citedby><cites>FETCH-LOGICAL-c4276-175cd50e25155db58edb2a5f1caee9e5f8c7b271456fabef8fcabca3139e1b583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbm.b.30106$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbm.b.30106$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15389509$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shih, Hsin-Nung</creatorcontrib><creatorcontrib>Fang, Jen-Feng</creatorcontrib><creatorcontrib>Chen, Jui-Hsiang</creatorcontrib><creatorcontrib>Yang, Chiung-Lin</creatorcontrib><creatorcontrib>Chen, Yu-Hua</creatorcontrib><creatorcontrib>Sung, Tseng-Hwa</creatorcontrib><creatorcontrib>Shih, Lih-Yuann</creatorcontrib><title>Reduction in experimental peridural adhesion with the use of a crosslinked hyaluronate/collagen membrane</title><title>Journal of biomedical materials research</title><addtitle>J. Biomed. Mater. Res</addtitle><description>The research goals were to fabricate a crosslinked hyaluronate (HA)/collagen membrane and study its efficacy in preventing peridural adhesion. Different weight ratios of HA/collagen membranes crosslinked with carbodiimide were tested for biocompatibility and biodegradability first. Forty‐eight adult New Zealand white rabbits underwent an L6 laminectomy. Sixteen rabbits each received a weight ratio of HA/collagen = 60/40 membrane (Membrane A) or a 40/60 membrane (Membrane B) on the exposed dura. The last 16 rabbits received no treatment and served as controls. No adverse reaction of the membranes was noted. Magnetic resonance images revealed a hyposignal space between the dura and the scar tissues at Membrane B‐treated laminectomy site 3 months after surgery. Histological examination showed that the amount of scarring decreased with time in all groups. Amount of scarring decreased significantly at laminectomy sites treated with either membrane. Compared with the control group, the extent of peridural adhesion decreased significantly in the Membrane B‐treated group at 3 months after surgery; while it decreased substantially, but not significantly, in the Membrane A‐treated group. The carbodiimide‐crosslinked HA/collagen membrane is a safe and effective antiadhesive material in vivo. When placed onto the laminectomy site, the membrane with a weight ratio of HA/collagen = 40/60 appears to reduce peridural scar adhesion. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 71B: 421–428, 2004</description><subject>Animals</subject><subject>Biocompatible Materials</subject><subject>Bone Regeneration - drug effects</subject><subject>carbodiimide (EDC)</subject><subject>Cicatrix - pathology</subject><subject>Collagen - chemistry</subject><subject>Cross-Linking Reagents</subject><subject>crosslinking</subject><subject>Epidural Space - pathology</subject><subject>hyaluronic acid (HA)</subject><subject>Hyaluronic Acid - chemistry</subject><subject>laminectomy</subject><subject>laminectomy, peridural scar adhesion</subject><subject>Magnetic Resonance Imaging</subject><subject>Materials Testing</subject><subject>Myelography</subject><subject>peridural scar adhesion</subject><subject>Rabbits</subject><subject>Tissue Adhesions - prevention & control</subject><issn>1552-4973</issn><issn>0021-9304</issn><issn>1552-4981</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1PGzEQxa2KqlDoiTvyiUu1icde78exjdoASmlBqXq0bO8su7Afwd4V5L_HISnc4DTv8JunmfcIOQY2Acb49Na0EzMRDFjygRyAlDyK8wz2XnQq9sln728DnDApPpF9kCLLJcsPSHWNxWiHuu9o3VF8XKGrW-wG3dCNLEYXlC4q9BvkoR4qOlRIR4-0L6mm1vXeN3V3hwWt1roZXd_pAae2bxp9gx1tsTVOd3hEPpa68fhlNw_J358_lrOzaPF7fj77tohszNMkglTaQjLkMhxfGJlhYbiWJViNmKMsM5sankIsk1IbLLPSamO1AJEjBFwcktOt78r19yP6QbW1txiu6bAfvUpSxiCO4V2QM5nwPOHvgpCKTIo8DuDXLfgcisNSrUKY2q0VMLWpSoWqlFHPVQX6ZGc7mhaLV3bXTQBgCzzUDa7f8lIX33_9N422O7Uf8PFlR7u78LhIpfp3OVd_YAlX8-VcXYsnl5mwRA</recordid><startdate>20041115</startdate><enddate>20041115</enddate><creator>Shih, Hsin-Nung</creator><creator>Fang, Jen-Feng</creator><creator>Chen, Jui-Hsiang</creator><creator>Yang, Chiung-Lin</creator><creator>Chen, Yu-Hua</creator><creator>Sung, Tseng-Hwa</creator><creator>Shih, Lih-Yuann</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20041115</creationdate><title>Reduction in experimental peridural adhesion with the use of a crosslinked hyaluronate/collagen membrane</title><author>Shih, Hsin-Nung ; Fang, Jen-Feng ; Chen, Jui-Hsiang ; Yang, Chiung-Lin ; Chen, Yu-Hua ; Sung, Tseng-Hwa ; Shih, Lih-Yuann</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4276-175cd50e25155db58edb2a5f1caee9e5f8c7b271456fabef8fcabca3139e1b583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Biocompatible Materials</topic><topic>Bone Regeneration - drug effects</topic><topic>carbodiimide (EDC)</topic><topic>Cicatrix - pathology</topic><topic>Collagen - chemistry</topic><topic>Cross-Linking Reagents</topic><topic>crosslinking</topic><topic>Epidural Space - pathology</topic><topic>hyaluronic acid (HA)</topic><topic>Hyaluronic Acid - chemistry</topic><topic>laminectomy</topic><topic>laminectomy, peridural scar adhesion</topic><topic>Magnetic Resonance Imaging</topic><topic>Materials Testing</topic><topic>Myelography</topic><topic>peridural scar adhesion</topic><topic>Rabbits</topic><topic>Tissue Adhesions - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shih, Hsin-Nung</creatorcontrib><creatorcontrib>Fang, Jen-Feng</creatorcontrib><creatorcontrib>Chen, Jui-Hsiang</creatorcontrib><creatorcontrib>Yang, Chiung-Lin</creatorcontrib><creatorcontrib>Chen, Yu-Hua</creatorcontrib><creatorcontrib>Sung, Tseng-Hwa</creatorcontrib><creatorcontrib>Shih, Lih-Yuann</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biomedical materials research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shih, Hsin-Nung</au><au>Fang, Jen-Feng</au><au>Chen, Jui-Hsiang</au><au>Yang, Chiung-Lin</au><au>Chen, Yu-Hua</au><au>Sung, Tseng-Hwa</au><au>Shih, Lih-Yuann</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduction in experimental peridural adhesion with the use of a crosslinked hyaluronate/collagen membrane</atitle><jtitle>Journal of biomedical materials research</jtitle><addtitle>J. Biomed. Mater. Res</addtitle><date>2004-11-15</date><risdate>2004</risdate><volume>71B</volume><issue>2</issue><spage>421</spage><epage>428</epage><pages>421-428</pages><issn>1552-4973</issn><issn>0021-9304</issn><eissn>1552-4981</eissn><abstract>The research goals were to fabricate a crosslinked hyaluronate (HA)/collagen membrane and study its efficacy in preventing peridural adhesion. Different weight ratios of HA/collagen membranes crosslinked with carbodiimide were tested for biocompatibility and biodegradability first. Forty‐eight adult New Zealand white rabbits underwent an L6 laminectomy. Sixteen rabbits each received a weight ratio of HA/collagen = 60/40 membrane (Membrane A) or a 40/60 membrane (Membrane B) on the exposed dura. The last 16 rabbits received no treatment and served as controls. No adverse reaction of the membranes was noted. Magnetic resonance images revealed a hyposignal space between the dura and the scar tissues at Membrane B‐treated laminectomy site 3 months after surgery. Histological examination showed that the amount of scarring decreased with time in all groups. Amount of scarring decreased significantly at laminectomy sites treated with either membrane. Compared with the control group, the extent of peridural adhesion decreased significantly in the Membrane B‐treated group at 3 months after surgery; while it decreased substantially, but not significantly, in the Membrane A‐treated group. The carbodiimide‐crosslinked HA/collagen membrane is a safe and effective antiadhesive material in vivo. When placed onto the laminectomy site, the membrane with a weight ratio of HA/collagen = 40/60 appears to reduce peridural scar adhesion. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 71B: 421–428, 2004</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>15389509</pmid><doi>10.1002/jbm.b.30106</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1552-4973 |
| ispartof | Journal of biomedical materials research, 2004-11, Vol.71B (2), p.421-428 |
| issn | 1552-4973 0021-9304 1552-4981 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67001441 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Animals Biocompatible Materials Bone Regeneration - drug effects carbodiimide (EDC) Cicatrix - pathology Collagen - chemistry Cross-Linking Reagents crosslinking Epidural Space - pathology hyaluronic acid (HA) Hyaluronic Acid - chemistry laminectomy laminectomy, peridural scar adhesion Magnetic Resonance Imaging Materials Testing Myelography peridural scar adhesion Rabbits Tissue Adhesions - prevention & control |
| title | Reduction in experimental peridural adhesion with the use of a crosslinked hyaluronate/collagen membrane |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T21%3A05%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Reduction%20in%20experimental%20peridural%20adhesion%20with%20the%20use%20of%20a%20crosslinked%20hyaluronate/collagen%20membrane&rft.jtitle=Journal%20of%20biomedical%20materials%20research&rft.au=Shih,%20Hsin-Nung&rft.date=2004-11-15&rft.volume=71B&rft.issue=2&rft.spage=421&rft.epage=428&rft.pages=421-428&rft.issn=1552-4973&rft.eissn=1552-4981&rft_id=info:doi/10.1002/jbm.b.30106&rft_dat=%3Cproquest_cross%3E20562962%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17385394&rft_id=info:pmid/15389509&rfr_iscdi=true |