C3a and C5a Are Chemotactic Factors for Human Mesenchymal Stem Cells, Which Cause Prolonged ERK1/2 Phosphorylation

Mesenchymal stem cells (MSCs) have a great potential for tissue repair, especially if they can be delivered efficiently to sites of tissue injury. Since complement activation occurs whenever there is tissue damage, the effects of the complement activation products C3a and C5a on MSCs were examined....

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Veröffentlicht in:	The Journal of immunology (1950) 2009-03, Vol.182 (6), p.3827-3836
Hauptverfasser:	Schraufstatter, Ingrid U, DiScipio, Richard G, Zhao, Ming, Khaldoyanidi, Sophia K
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line Cells, Cultured Chemotactic Factors - physiology Chemotaxis, Leukocyte - immunology Complement C3a - physiology Complement C5a - physiology Humans Mesenchymal Stromal Cells - enzymology Mesenchymal Stromal Cells - immunology Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Phosphorylation Proto-Oncogene Proteins c-akt - metabolism Receptor, Anaphylatoxin C5a Receptors, Complement - biosynthesis Receptors, Complement - genetics Time Factors
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