A topological sub-structural approach for predicting human intestinal absorption of drugs

The human intestinal absorption (HIA) of drugs was studied using a topological sub-structural approach (TOPS-MODE). The drugs were divided into three classes according to reported cutoff values for HIA. “Poor” absorption was defined as HIA ≤30%, “high” absorption as HIA ≥80%, whereas “moderate” abso...

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Veröffentlicht in:	European journal of medicinal chemistry 2004-11, Vol.39 (11), p.905-916
Hauptverfasser:	Pérez, Miguel Angel Cabrera, Sanz, Marival Bermejo, Torres, Liliana Ramos, Ávalos, Ricardo Grau, González, Maykel Pérez, Díaz, Humberto González
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biological Availability Discriminant analysis Humans In silico Intestinal Absorption Intestinal Mucosa - metabolism Medical sciences Miscellaneous Models, Theoretical Pharmaceutical Preparations - metabolism Pharmacology. Drug treatments Quantitative Structure-Activity Relationship Sub-structural approach
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