Effect of blocking platelet activation with AZD6140 on development of abdominal aortic aneurysm in a rat aneurysmal model

Background Platelet activation and thrombus renewal are keys to intraluminal thrombus formation and progression of abdominal aortic aneurysms (AAA). This study explored the ability of AZD6140 , a P2Y 12 receptor antagonist, to inhibit platelet activation and prevent aneurysm development in a rat exp...

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Veröffentlicht in:	Journal of vascular surgery 2009-03, Vol.49 (3), p.719-727
Hauptverfasser:	Dai, Jianping, MD, PhD, Louedec, Liliane, BSc, Philippe, Monique, BSc, Michel, Jean-Baptiste, MD, PhD, Houard, Xavier, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine - pharmacology Adenosine Diphosphate Animals Aorta - drug effects Aorta - pathology Aorta - transplantation Aortic Aneurysm, Abdominal - blood Aortic Aneurysm, Abdominal - etiology Aortic Aneurysm, Abdominal - pathology Aortic Aneurysm, Abdominal - prevention & control Biological and medical sciences Blood and lymphatic vessels Blood Platelets - drug effects Blood Platelets - metabolism Cardiology. Vascular system Disease Models, Animal Disease Progression Diseases of the aorta Elastic Tissue - drug effects Elastic Tissue - pathology Guinea Pigs Inflammation - blood Inflammation - etiology Inflammation - prevention & control Male Matrix Metalloproteinase 9 - metabolism Medical sciences Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - pathology Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - pathology Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - pharmacology Purinergic P2 Receptor Antagonists Rats Rats, Inbred Lew Receptors, Purinergic P2 - blood Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Thrombosis - blood Thrombosis - etiology Thrombosis - pathology Thrombosis - prevention & control Ticagrelor Time Factors Transplantation, Heterologous Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels
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