Value of (124)I-PET/CT in staging of patients with differentiated thyroid cancer
The aim of this study is to evaluate the clinical significance of (124)I positron emission tomography (PET) using a combined PET/CT tomograph in patients with differentiated thyroid carcinoma and to compare the PET/CT results with (131)I whole-body scintigraphy (WBS), dedicated PET and CT alone. Twe...
Gespeichert in:
| Veröffentlicht in: | European radiology 2004-11, Vol.14 (11), p.2092-2098 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2098 |
|---|---|
| container_issue | 11 |
| container_start_page | 2092 |
| container_title | European radiology |
| container_volume | 14 |
| creator | Freudenberg, L S Antoch, G Jentzen, W Pink, R Knust, J Görges, R Müller, S P Bockisch, A Debatin, J F Brandau, W |
| description | The aim of this study is to evaluate the clinical significance of (124)I positron emission tomography (PET) using a combined PET/CT tomograph in patients with differentiated thyroid carcinoma and to compare the PET/CT results with (131)I whole-body scintigraphy (WBS), dedicated PET and CT alone. Twelve thyroid cancer patients were referred for diagnostic workup and entered complete clinical evaluation, including histology, cytology, thyroglobulin level, ultrasonography, fluorine-18 fluorodeoxyglucose (FDG)-PET, FDG-PET/CT and CT. Lesion-based evaluation showed a lesion delectability of 56, 87 and 100% for CT, (124)I-PET, and combined (124)I-PET/CT imaging, respectively. Lesion delectability of (131)I-WBS was 83%. We conclude that (124)I-PET/CT imaging is a promising technique to improve treatment planning in thyroid cancer. It is particularly valuable in patients suffering from advanced differentiated thyroid cancer prior to radio-iodine therapy and in patients with suspected recurrence and potential metastatic disease. |
| doi_str_mv | 10.1007/s00330-004-2350-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_67000184</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67000184</sourcerecordid><originalsourceid>FETCH-LOGICAL-p122t-9c0bbfb7c4546f777c7317ec6fc7dbf32b7934e91fb1c10d8373880efc6b4d2a3</originalsourceid><addsrcrecordid>eNo1UEtLw0AY3INia_UHeJE9iR7WfvtoNjlKqVoo2EP0GvbZrqRJzG6Q_nsj1tPMMMPADEI3FB4pgJxHAM6BAAjC-GIkZ2gKBc-JLAoxQZcxfgJAQYW8QBO6YJxJyKdo-6HqweHW43vKxMOabFflfFni0OCY1C40u1-vUym4JkX8HdIe2-C960cdVHIWp_2xb4PFRjXG9Vfo3Ks6uusTztD786pcvpLN28t6-bQhHWUskcKA1l5LIxYi81JKIzmVzmTeSKs9Z1oWXLiCek0NBZtzyfMcnDeZFpYpPkN3f71d334NLqbqEKJxda0a1w6xyuQ4l-ZiDN6egoM-OFt1fTio_lj9f8B_AHOCW0k</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67000184</pqid></control><display><type>article</type><title>Value of (124)I-PET/CT in staging of patients with differentiated thyroid cancer</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Freudenberg, L S ; Antoch, G ; Jentzen, W ; Pink, R ; Knust, J ; Görges, R ; Müller, S P ; Bockisch, A ; Debatin, J F ; Brandau, W</creator><creatorcontrib>Freudenberg, L S ; Antoch, G ; Jentzen, W ; Pink, R ; Knust, J ; Görges, R ; Müller, S P ; Bockisch, A ; Debatin, J F ; Brandau, W</creatorcontrib><description>The aim of this study is to evaluate the clinical significance of (124)I positron emission tomography (PET) using a combined PET/CT tomograph in patients with differentiated thyroid carcinoma and to compare the PET/CT results with (131)I whole-body scintigraphy (WBS), dedicated PET and CT alone. Twelve thyroid cancer patients were referred for diagnostic workup and entered complete clinical evaluation, including histology, cytology, thyroglobulin level, ultrasonography, fluorine-18 fluorodeoxyglucose (FDG)-PET, FDG-PET/CT and CT. Lesion-based evaluation showed a lesion delectability of 56, 87 and 100% for CT, (124)I-PET, and combined (124)I-PET/CT imaging, respectively. Lesion delectability of (131)I-WBS was 83%. We conclude that (124)I-PET/CT imaging is a promising technique to improve treatment planning in thyroid cancer. It is particularly valuable in patients suffering from advanced differentiated thyroid cancer prior to radio-iodine therapy and in patients with suspected recurrence and potential metastatic disease.</description><identifier>ISSN: 0938-7994</identifier><identifier>DOI: 10.1007/s00330-004-2350-0</identifier><identifier>PMID: 15232708</identifier><language>eng</language><publisher>Germany</publisher><subject>Adult ; Aged ; Carcinoma - classification ; Carcinoma - diagnosis ; Female ; Humans ; Iodine Radioisotopes ; Lymph Nodes - diagnostic imaging ; Male ; Middle Aged ; Neoplasm Staging ; Positron-Emission Tomography - methods ; Reproducibility of Results ; Thyroid Gland - diagnostic imaging ; Thyroid Neoplasms - classification ; Thyroid Neoplasms - diagnosis ; Tomography, X-Ray Computed - methods ; Ultrasonography</subject><ispartof>European radiology, 2004-11, Vol.14 (11), p.2092-2098</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15232708$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Freudenberg, L S</creatorcontrib><creatorcontrib>Antoch, G</creatorcontrib><creatorcontrib>Jentzen, W</creatorcontrib><creatorcontrib>Pink, R</creatorcontrib><creatorcontrib>Knust, J</creatorcontrib><creatorcontrib>Görges, R</creatorcontrib><creatorcontrib>Müller, S P</creatorcontrib><creatorcontrib>Bockisch, A</creatorcontrib><creatorcontrib>Debatin, J F</creatorcontrib><creatorcontrib>Brandau, W</creatorcontrib><title>Value of (124)I-PET/CT in staging of patients with differentiated thyroid cancer</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><description>The aim of this study is to evaluate the clinical significance of (124)I positron emission tomography (PET) using a combined PET/CT tomograph in patients with differentiated thyroid carcinoma and to compare the PET/CT results with (131)I whole-body scintigraphy (WBS), dedicated PET and CT alone. Twelve thyroid cancer patients were referred for diagnostic workup and entered complete clinical evaluation, including histology, cytology, thyroglobulin level, ultrasonography, fluorine-18 fluorodeoxyglucose (FDG)-PET, FDG-PET/CT and CT. Lesion-based evaluation showed a lesion delectability of 56, 87 and 100% for CT, (124)I-PET, and combined (124)I-PET/CT imaging, respectively. Lesion delectability of (131)I-WBS was 83%. We conclude that (124)I-PET/CT imaging is a promising technique to improve treatment planning in thyroid cancer. It is particularly valuable in patients suffering from advanced differentiated thyroid cancer prior to radio-iodine therapy and in patients with suspected recurrence and potential metastatic disease.</description><subject>Adult</subject><subject>Aged</subject><subject>Carcinoma - classification</subject><subject>Carcinoma - diagnosis</subject><subject>Female</subject><subject>Humans</subject><subject>Iodine Radioisotopes</subject><subject>Lymph Nodes - diagnostic imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Positron-Emission Tomography - methods</subject><subject>Reproducibility of Results</subject><subject>Thyroid Gland - diagnostic imaging</subject><subject>Thyroid Neoplasms - classification</subject><subject>Thyroid Neoplasms - diagnosis</subject><subject>Tomography, X-Ray Computed - methods</subject><subject>Ultrasonography</subject><issn>0938-7994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1UEtLw0AY3INia_UHeJE9iR7WfvtoNjlKqVoo2EP0GvbZrqRJzG6Q_nsj1tPMMMPADEI3FB4pgJxHAM6BAAjC-GIkZ2gKBc-JLAoxQZcxfgJAQYW8QBO6YJxJyKdo-6HqweHW43vKxMOabFflfFni0OCY1C40u1-vUym4JkX8HdIe2-C960cdVHIWp_2xb4PFRjXG9Vfo3Ks6uusTztD786pcvpLN28t6-bQhHWUskcKA1l5LIxYi81JKIzmVzmTeSKs9Z1oWXLiCek0NBZtzyfMcnDeZFpYpPkN3f71d334NLqbqEKJxda0a1w6xyuQ4l-ZiDN6egoM-OFt1fTio_lj9f8B_AHOCW0k</recordid><startdate>200411</startdate><enddate>200411</enddate><creator>Freudenberg, L S</creator><creator>Antoch, G</creator><creator>Jentzen, W</creator><creator>Pink, R</creator><creator>Knust, J</creator><creator>Görges, R</creator><creator>Müller, S P</creator><creator>Bockisch, A</creator><creator>Debatin, J F</creator><creator>Brandau, W</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200411</creationdate><title>Value of (124)I-PET/CT in staging of patients with differentiated thyroid cancer</title><author>Freudenberg, L S ; Antoch, G ; Jentzen, W ; Pink, R ; Knust, J ; Görges, R ; Müller, S P ; Bockisch, A ; Debatin, J F ; Brandau, W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p122t-9c0bbfb7c4546f777c7317ec6fc7dbf32b7934e91fb1c10d8373880efc6b4d2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Carcinoma - classification</topic><topic>Carcinoma - diagnosis</topic><topic>Female</topic><topic>Humans</topic><topic>Iodine Radioisotopes</topic><topic>Lymph Nodes - diagnostic imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Positron-Emission Tomography - methods</topic><topic>Reproducibility of Results</topic><topic>Thyroid Gland - diagnostic imaging</topic><topic>Thyroid Neoplasms - classification</topic><topic>Thyroid Neoplasms - diagnosis</topic><topic>Tomography, X-Ray Computed - methods</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Freudenberg, L S</creatorcontrib><creatorcontrib>Antoch, G</creatorcontrib><creatorcontrib>Jentzen, W</creatorcontrib><creatorcontrib>Pink, R</creatorcontrib><creatorcontrib>Knust, J</creatorcontrib><creatorcontrib>Görges, R</creatorcontrib><creatorcontrib>Müller, S P</creatorcontrib><creatorcontrib>Bockisch, A</creatorcontrib><creatorcontrib>Debatin, J F</creatorcontrib><creatorcontrib>Brandau, W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Freudenberg, L S</au><au>Antoch, G</au><au>Jentzen, W</au><au>Pink, R</au><au>Knust, J</au><au>Görges, R</au><au>Müller, S P</au><au>Bockisch, A</au><au>Debatin, J F</au><au>Brandau, W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Value of (124)I-PET/CT in staging of patients with differentiated thyroid cancer</atitle><jtitle>European radiology</jtitle><addtitle>Eur Radiol</addtitle><date>2004-11</date><risdate>2004</risdate><volume>14</volume><issue>11</issue><spage>2092</spage><epage>2098</epage><pages>2092-2098</pages><issn>0938-7994</issn><abstract>The aim of this study is to evaluate the clinical significance of (124)I positron emission tomography (PET) using a combined PET/CT tomograph in patients with differentiated thyroid carcinoma and to compare the PET/CT results with (131)I whole-body scintigraphy (WBS), dedicated PET and CT alone. Twelve thyroid cancer patients were referred for diagnostic workup and entered complete clinical evaluation, including histology, cytology, thyroglobulin level, ultrasonography, fluorine-18 fluorodeoxyglucose (FDG)-PET, FDG-PET/CT and CT. Lesion-based evaluation showed a lesion delectability of 56, 87 and 100% for CT, (124)I-PET, and combined (124)I-PET/CT imaging, respectively. Lesion delectability of (131)I-WBS was 83%. We conclude that (124)I-PET/CT imaging is a promising technique to improve treatment planning in thyroid cancer. It is particularly valuable in patients suffering from advanced differentiated thyroid cancer prior to radio-iodine therapy and in patients with suspected recurrence and potential metastatic disease.</abstract><cop>Germany</cop><pmid>15232708</pmid><doi>10.1007/s00330-004-2350-0</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0938-7994 |
| ispartof | European radiology, 2004-11, Vol.14 (11), p.2092-2098 |
| issn | 0938-7994 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67000184 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Adult Aged Carcinoma - classification Carcinoma - diagnosis Female Humans Iodine Radioisotopes Lymph Nodes - diagnostic imaging Male Middle Aged Neoplasm Staging Positron-Emission Tomography - methods Reproducibility of Results Thyroid Gland - diagnostic imaging Thyroid Neoplasms - classification Thyroid Neoplasms - diagnosis Tomography, X-Ray Computed - methods Ultrasonography |
| title | Value of (124)I-PET/CT in staging of patients with differentiated thyroid cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T12%3A18%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Value%20of%20(124)I-PET/CT%20in%20staging%20of%20patients%20with%20differentiated%20thyroid%20cancer&rft.jtitle=European%20radiology&rft.au=Freudenberg,%20L%20S&rft.date=2004-11&rft.volume=14&rft.issue=11&rft.spage=2092&rft.epage=2098&rft.pages=2092-2098&rft.issn=0938-7994&rft_id=info:doi/10.1007/s00330-004-2350-0&rft_dat=%3Cproquest_pubme%3E67000184%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67000184&rft_id=info:pmid/15232708&rfr_iscdi=true |