Effects of adenosine on optic nerve head circulation in rabbits

This study was performed to determine whether intravitreal or intravenous adenosine can alter the microcirculation in the optic nerve head (ONH) of rabbits. Capillary blood flow in the ONH was measured serially with a laser speckle tissue analyser for 2 hr after the intravitreal (0·1, 1·0 and 10 nmo...

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Veröffentlicht in:	Experimental eye research 2004-11, Vol.79 (5), p.729-735
Hauptverfasser:	Hirao, Mami, Oku, Hidehiro, Goto, Wakana, Sugiyama, Tetsuya, Kobayashi, Takatoshi, Ikeda, Tsunehiko
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Bromo Cyclic Adenosine Monophosphate - pharmacology adenosine Adenosine - analogs & derivatives Adenosine - antagonists & inhibitors Adenosine - pharmacology Adenosine A1 Receptor Antagonists adenosine receptors Adenylyl Cyclase Inhibitors Animals ATP-sensitive potassium channels Caffeine - analogs & derivatives Caffeine - pharmacology Capillaries capillary blood flow Dose-Response Relationship, Drug Glyburide - pharmacology Injections Injections, Intravenous laser speckle method Optic Disk - blood supply optic nerve head Phenethylamines - pharmacology Potassium Channels - drug effects Purinergic P1 Receptor Agonists Purinergic P2 Receptor Antagonists rabbit Rabbits Regional Blood Flow - drug effects Stimulation, Chemical Vasodilation - physiology Vitreous Body Xanthines - pharmacology
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