Synthesis and in vitro antitumor activity of new quinoxaline derivatives

A series of novel 5,7-diamino-3-phenyl-2-benzylamino, 2-phenoxy, and 2-thiophenyl substituted quinoxalines has been designed, synthesized and evaluated for their in vitro antitumor activity towards cell lines of nine different types of human cancers. Some of these compounds exhibited inhibitory effe...

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Veröffentlicht in:	European journal of medicinal chemistry 2009-04, Vol.44 (4), p.1579-1591
Hauptverfasser:	Corona, Paola, Carta, Antonio, Loriga, Mario, Vitale, Gabriella, Paglietti, Giuseppe
Format:	Artikel
Sprache:	eng
Schlagworte:	5,7-Diamino-3-phenyl-2-benzylamino, 2-phenoxy and 2-phenylthio substituted quinoxalines Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antitumor activity Biological and medical sciences Cell Line, Tumor Drug Design General aspects Humans Medical sciences Pharmacology. Drug treatments Quinoxalines - chemical synthesis Quinoxalines - chemistry Quinoxalines - pharmacology
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