Inhibitor binding at the protein interface in crystals of a HIV-1 protease complex

Depending on the excess of ligand used for complex formation, the HIV‐1 protease complexed with a novel phenylnorstatine inhibitor forms crystals of either hexagonal (P61) or orthorhombic (P212121) symmetry. The orthorhombic form shows an unusual complexity of crystal packing: in addition to one inh...

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Veröffentlicht in:	Acta crystallographica. Section D, Biological crystallography. Biological crystallography., 2004-11, Vol.60 (11), p.1943-1948
Hauptverfasser:	Brynda, Jiří, Řezáčová, Pavlína, Fábry, Milan, Hořejší, Magdalena, Štouračová, Renata, Souček, Milan, Hradílek, Martin, Konvalinka, Jan, Sedláček, Juraj
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites crystal packing Crystallography, X-Ray HIV Protease - chemistry HIV Protease - metabolism HIV Protease Inhibitors - chemistry HIV Protease Inhibitors - metabolism HIV-1 protease Ligands Models, Molecular phenylnorstatine inhibitor Protein Conformation Sensitivity and Specificity
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