The use of inverse phase gas chromatography to study the glass transition temperature of a powder surface

To measure the glass transition temperature (Tg) at the surface of a hydrophobic particle at different temperatures and humidities, on the hypothesis that the surface may be plasticized to a different extent to the bulk due to slow water sorption giving a concentration gradient of water through the...

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Veröffentlicht in:	Pharmaceutical research 2004-09, Vol.21 (9), p.1554-1557
Hauptverfasser:	Buckton, Graham, Ambarkhane, Ameet, Pincott, Kim
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents, Non-Steroidal - chemistry Chromatography Chromatography, Gas - methods Crystallization Humidity Hydrophobic and Hydrophilic Interactions Indomethacin - chemistry Powders - chemistry Retention Temperature Thermodynamics Water - chemistry
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