Pulmonary hypertension in sickle cell disease
Recurrent vaso-occlusive episodes lead to progressive end-organ damage in patients with sickle cell disease. We sought to determine the prevalence of pulmonary hypertension in adult patients with sickle cell disease and to identify factors associated with this life-threatening complication. Sixty pa...
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| Veröffentlicht in: | The American journal of medicine 2004-11, Vol.117 (9), p.665-669 |
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| container_title | The American journal of medicine |
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| creator | Ataga, Kenneth I. Sood, Namita De Gent, Guy Kelly, Eileen Henderson, Ashley G. Jones, Susan Strayhorn, Dell Lail, Alice Lieff, Susan Orringer, Eugene P. |
| description | Recurrent vaso-occlusive episodes lead to progressive end-organ damage in patients with sickle cell disease. We sought to determine the prevalence of pulmonary hypertension in adult patients with sickle cell disease and to identify factors associated with this life-threatening complication.
Sixty patients (≥18 years of age; mean [± SD] age, 37 ± 13 years) followed at a University Medical Center were evaluated. They were selected by a systematic sampling of patients presenting to the clinic for routine follow-up visits. All enrolled subjects underwent a clinical examination, Doppler echocardiography, pulmonary function tests, and hematologic tests during a single visit. Pulmonary hypertension was defined using an age- and body mass index–adjusted nomogram.
The prevalence of pulmonary hypertension was 30% (18/60). Ten patients had mild pulmonary hypertension (up to 44 mm Hg), 5 had moderate pulmonary hypertension (45 to 74 mm Hg), and 2 had severe pulmonary hypertension (≥75 mm Hg). In a logistic regression model, both lower fetal hemoglobin level and lower systolic blood pressure were associated with the presence of pulmonary hypertension.
We found that the prevalence of pulmonary hypertension in adult patients with sickle cell disease was substantial, particularly in those with lower levels of fetal hemoglobin and lower systolic blood pressure. |
| doi_str_mv | 10.1016/j.amjmed.2004.03.034 |
| format | Article |
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Sixty patients (≥18 years of age; mean [± SD] age, 37 ± 13 years) followed at a University Medical Center were evaluated. They were selected by a systematic sampling of patients presenting to the clinic for routine follow-up visits. All enrolled subjects underwent a clinical examination, Doppler echocardiography, pulmonary function tests, and hematologic tests during a single visit. Pulmonary hypertension was defined using an age- and body mass index–adjusted nomogram.
The prevalence of pulmonary hypertension was 30% (18/60). Ten patients had mild pulmonary hypertension (up to 44 mm Hg), 5 had moderate pulmonary hypertension (45 to 74 mm Hg), and 2 had severe pulmonary hypertension (≥75 mm Hg). In a logistic regression model, both lower fetal hemoglobin level and lower systolic blood pressure were associated with the presence of pulmonary hypertension.
We found that the prevalence of pulmonary hypertension in adult patients with sickle cell disease was substantial, particularly in those with lower levels of fetal hemoglobin and lower systolic blood pressure.</description><identifier>ISSN: 0002-9343</identifier><identifier>EISSN: 1555-7162</identifier><identifier>DOI: 10.1016/j.amjmed.2004.03.034</identifier><identifier>PMID: 15501204</identifier><identifier>CODEN: AJMEAZ</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Anemia, Sickle Cell - complications ; Anemia, Sickle Cell - diagnosis ; Anemia, Sickle Cell - epidemiology ; Biological and medical sciences ; Blood pressure ; Cross-Sectional Studies ; Echocardiography, Doppler ; Female ; General aspects ; Health risk assessment ; Hematologic Tests ; Humans ; Hypertension ; Hypertension, Pulmonary - diagnosis ; Hypertension, Pulmonary - epidemiology ; Hypertension, Pulmonary - etiology ; Logistic Models ; Male ; Medical sciences ; Pneumology ; Prevalence ; Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases ; Respiratory Function Tests ; Sickle cell anemia</subject><ispartof>The American journal of medicine, 2004-11, Vol.117 (9), p.665-669</ispartof><rights>2004 Elsevier Inc.</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Elsevier Sequoia S.A. Nov 1, 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-1a92955fdcf3b00344b47187782f74ba9adea85e1aecdfb255e215552cb7879b3</citedby><cites>FETCH-LOGICAL-c417t-1a92955fdcf3b00344b47187782f74ba9adea85e1aecdfb255e215552cb7879b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.amjmed.2004.03.034$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16227732$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15501204$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ataga, Kenneth I.</creatorcontrib><creatorcontrib>Sood, Namita</creatorcontrib><creatorcontrib>De Gent, Guy</creatorcontrib><creatorcontrib>Kelly, Eileen</creatorcontrib><creatorcontrib>Henderson, Ashley G.</creatorcontrib><creatorcontrib>Jones, Susan</creatorcontrib><creatorcontrib>Strayhorn, Dell</creatorcontrib><creatorcontrib>Lail, Alice</creatorcontrib><creatorcontrib>Lieff, Susan</creatorcontrib><creatorcontrib>Orringer, Eugene P.</creatorcontrib><title>Pulmonary hypertension in sickle cell disease</title><title>The American journal of medicine</title><addtitle>Am J Med</addtitle><description>Recurrent vaso-occlusive episodes lead to progressive end-organ damage in patients with sickle cell disease. We sought to determine the prevalence of pulmonary hypertension in adult patients with sickle cell disease and to identify factors associated with this life-threatening complication.
Sixty patients (≥18 years of age; mean [± SD] age, 37 ± 13 years) followed at a University Medical Center were evaluated. They were selected by a systematic sampling of patients presenting to the clinic for routine follow-up visits. All enrolled subjects underwent a clinical examination, Doppler echocardiography, pulmonary function tests, and hematologic tests during a single visit. Pulmonary hypertension was defined using an age- and body mass index–adjusted nomogram.
The prevalence of pulmonary hypertension was 30% (18/60). Ten patients had mild pulmonary hypertension (up to 44 mm Hg), 5 had moderate pulmonary hypertension (45 to 74 mm Hg), and 2 had severe pulmonary hypertension (≥75 mm Hg). In a logistic regression model, both lower fetal hemoglobin level and lower systolic blood pressure were associated with the presence of pulmonary hypertension.
We found that the prevalence of pulmonary hypertension in adult patients with sickle cell disease was substantial, particularly in those with lower levels of fetal hemoglobin and lower systolic blood pressure.</description><subject>Adult</subject><subject>Anemia, Sickle Cell - complications</subject><subject>Anemia, Sickle Cell - diagnosis</subject><subject>Anemia, Sickle Cell - epidemiology</subject><subject>Biological and medical sciences</subject><subject>Blood pressure</subject><subject>Cross-Sectional Studies</subject><subject>Echocardiography, Doppler</subject><subject>Female</subject><subject>General aspects</subject><subject>Health risk assessment</subject><subject>Hematologic Tests</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension, Pulmonary - diagnosis</subject><subject>Hypertension, Pulmonary - epidemiology</subject><subject>Hypertension, Pulmonary - etiology</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pneumology</subject><subject>Prevalence</subject><subject>Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases</subject><subject>Respiratory Function Tests</subject><subject>Sickle cell anemia</subject><issn>0002-9343</issn><issn>1555-7162</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kNtKxDAQhoMouq6-gUgR9K41x6a9EWTxBAt6odchTaeY2sOabIV9e1NaFLwQBoYh3wxffoTOCE4IJul1nei2bqFMKMY8wSwU30MLIoSIJUnpPlpgjGmcM86O0LH3dRhxLtJDdBQgTCjmCxS_DE3bd9rtovfdBtwWOm_7LrJd5K35aCAy0DRRaT1oDyfooNKNh9O5L9Hb_d3r6jFePz88rW7XseFEbmOic5oLUZWmYgUOXrzgkmRSZrSSvNC5LkFnAogGU1YFFQLo6E1NITOZF2yJrqa7G9d_DuC3qrV-FNEd9INXaZrnWUZoAC_-gHU_uC64KcooYzSTaYD4BBnXe--gUhtn2_BlRbAas1S1mrJUY5YKs1A8rJ3Pt4difPtZmsMLwOUMaG90UzndGet_uZRSKdkoeTNxECL7suCUNxY6A6V1YLaq7O3_Jt83wZIY</recordid><startdate>20041101</startdate><enddate>20041101</enddate><creator>Ataga, Kenneth I.</creator><creator>Sood, Namita</creator><creator>De Gent, Guy</creator><creator>Kelly, Eileen</creator><creator>Henderson, Ashley G.</creator><creator>Jones, Susan</creator><creator>Strayhorn, Dell</creator><creator>Lail, Alice</creator><creator>Lieff, Susan</creator><creator>Orringer, Eugene P.</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Sequoia S.A</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TO</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20041101</creationdate><title>Pulmonary hypertension in sickle cell disease</title><author>Ataga, Kenneth I. ; Sood, Namita ; De Gent, Guy ; Kelly, Eileen ; Henderson, Ashley G. ; Jones, Susan ; Strayhorn, Dell ; Lail, Alice ; Lieff, Susan ; Orringer, Eugene P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-1a92955fdcf3b00344b47187782f74ba9adea85e1aecdfb255e215552cb7879b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Anemia, Sickle Cell - complications</topic><topic>Anemia, Sickle Cell - diagnosis</topic><topic>Anemia, Sickle Cell - epidemiology</topic><topic>Biological and medical sciences</topic><topic>Blood pressure</topic><topic>Cross-Sectional Studies</topic><topic>Echocardiography, Doppler</topic><topic>Female</topic><topic>General aspects</topic><topic>Health risk assessment</topic><topic>Hematologic Tests</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension, Pulmonary - diagnosis</topic><topic>Hypertension, Pulmonary - epidemiology</topic><topic>Hypertension, Pulmonary - etiology</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pneumology</topic><topic>Prevalence</topic><topic>Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases</topic><topic>Respiratory Function Tests</topic><topic>Sickle cell anemia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ataga, Kenneth I.</creatorcontrib><creatorcontrib>Sood, Namita</creatorcontrib><creatorcontrib>De Gent, Guy</creatorcontrib><creatorcontrib>Kelly, Eileen</creatorcontrib><creatorcontrib>Henderson, Ashley G.</creatorcontrib><creatorcontrib>Jones, Susan</creatorcontrib><creatorcontrib>Strayhorn, Dell</creatorcontrib><creatorcontrib>Lail, Alice</creatorcontrib><creatorcontrib>Lieff, Susan</creatorcontrib><creatorcontrib>Orringer, Eugene P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ataga, Kenneth I.</au><au>Sood, Namita</au><au>De Gent, Guy</au><au>Kelly, Eileen</au><au>Henderson, Ashley G.</au><au>Jones, Susan</au><au>Strayhorn, Dell</au><au>Lail, Alice</au><au>Lieff, Susan</au><au>Orringer, Eugene P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pulmonary hypertension in sickle cell disease</atitle><jtitle>The American journal of medicine</jtitle><addtitle>Am J Med</addtitle><date>2004-11-01</date><risdate>2004</risdate><volume>117</volume><issue>9</issue><spage>665</spage><epage>669</epage><pages>665-669</pages><issn>0002-9343</issn><eissn>1555-7162</eissn><coden>AJMEAZ</coden><abstract>Recurrent vaso-occlusive episodes lead to progressive end-organ damage in patients with sickle cell disease. We sought to determine the prevalence of pulmonary hypertension in adult patients with sickle cell disease and to identify factors associated with this life-threatening complication.
Sixty patients (≥18 years of age; mean [± SD] age, 37 ± 13 years) followed at a University Medical Center were evaluated. They were selected by a systematic sampling of patients presenting to the clinic for routine follow-up visits. All enrolled subjects underwent a clinical examination, Doppler echocardiography, pulmonary function tests, and hematologic tests during a single visit. Pulmonary hypertension was defined using an age- and body mass index–adjusted nomogram.
The prevalence of pulmonary hypertension was 30% (18/60). Ten patients had mild pulmonary hypertension (up to 44 mm Hg), 5 had moderate pulmonary hypertension (45 to 74 mm Hg), and 2 had severe pulmonary hypertension (≥75 mm Hg). In a logistic regression model, both lower fetal hemoglobin level and lower systolic blood pressure were associated with the presence of pulmonary hypertension.
We found that the prevalence of pulmonary hypertension in adult patients with sickle cell disease was substantial, particularly in those with lower levels of fetal hemoglobin and lower systolic blood pressure.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15501204</pmid><doi>10.1016/j.amjmed.2004.03.034</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Anemia, Sickle Cell - complications Anemia, Sickle Cell - diagnosis Anemia, Sickle Cell - epidemiology Biological and medical sciences Blood pressure Cross-Sectional Studies Echocardiography, Doppler Female General aspects Health risk assessment Hematologic Tests Humans Hypertension Hypertension, Pulmonary - diagnosis Hypertension, Pulmonary - epidemiology Hypertension, Pulmonary - etiology Logistic Models Male Medical sciences Pneumology Prevalence Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Respiratory Function Tests Sickle cell anemia |
| title | Pulmonary hypertension in sickle cell disease |
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