Effects of chronic ingestion of catechin-rich green tea on hepatic gene expression of gluconeogenic enzymes in rats
Normal rats were given catechin-rich green tea as drinking fluid and the effects on hepatic gene expression were examined. The results of DNA microarray analysis and quantitative real-time reverse transcription-polymerase chain reaction indicated the down-regulated expression of genes for glucose-6-...
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| Veröffentlicht in: | Biomedical Research 2009, Vol.30(1), pp.25-29 |
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| container_title | Biomedical Research |
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| creator | Abe, Koichi Okada, Norihisa Tanabe, Hiroki Fukutomi, Ryuuta Yasui, Kensuke Isemura, Mamoru Kinae, Naohide |
| description | Normal rats were given catechin-rich green tea as drinking fluid and the effects on hepatic gene expression were examined. The results of DNA microarray analysis and quantitative real-time reverse transcription-polymerase chain reaction indicated the down-regulated expression of genes for glucose-6-phosphatase (G6Pase) and fatty acid synthase, and the up-regulated expression of peroxisome proliferator activated receptor α in the rats given green tea for 4 weeks as compared with the water-given animals. One may expect anti-diabetic activity by catechin-rich green tea through its chronic down-regulatory effect on G6Pase expression. |
| doi_str_mv | 10.2220/biomedres.30.25 |
| format | Article |
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The results of DNA microarray analysis and quantitative real-time reverse transcription-polymerase chain reaction indicated the down-regulated expression of genes for glucose-6-phosphatase (G6Pase) and fatty acid synthase, and the up-regulated expression of peroxisome proliferator activated receptor α in the rats given green tea for 4 weeks as compared with the water-given animals. 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| identifier | ISSN: 0388-6107 |
| ispartof | Biomedical Research, 2009, Vol.30(1), pp.25-29 |
| issn | 0388-6107 1880-313X |
| language | eng |
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| source | J-STAGE Free; MEDLINE; EZB Electronic Journals Library |
| subjects | Animals Catechin - pharmacology Fatty Acid Synthases - metabolism Gene Expression Regulation Gluconeogenesis Glucose-6-Phosphatase - metabolism Liver - metabolism Male Oligonucleotide Array Sequence Analysis PPAR alpha - metabolism Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction Tea - metabolism Time Factors |
| title | Effects of chronic ingestion of catechin-rich green tea on hepatic gene expression of gluconeogenic enzymes in rats |
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