Widespread Mismatch Repair Protein Expression in Canine Cutaneous Mast Cell Tumors

Cutaneous mast cell tumors (MCTs) are common canine neoplasms. Some dog breeds more frequently develop MCTs, suggesting a genetically mediated predisposition. In humans, the most common inherited cancer predisposition is caused by germline defects in the mismatch repair (MMR) genes. To investigate w...

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Veröffentlicht in:	Veterinary pathology 2009-03, Vol.46 (2), p.227-232
Hauptverfasser:	Munday, J.S, French, A.F, Gibson, I.R, Gwynne, K
Format:	Artikel
Sprache:	eng
Schlagworte:	animal genetics Animals base pair mismatch carcinogenesis disease predisposition disease resistance DNA Mismatch Repair - physiology DNA repair dog diseases Dog Diseases - metabolism Dogs gene expression Gene Expression Regulation, Neoplastic - physiology Genetic Predisposition to Disease immunohistochemistry Lynch Syndrome mast cell tumor mast cells Mastocytosis, Cutaneous - genetics Mastocytosis, Cutaneous - metabolism Mastocytosis, Cutaneous - veterinary Muir-Torre syndrome neoplasms old animals protein synthesis skin skin diseases
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