Fetal magnetic resonance imaging in isolated diaphragmatic hernia: volume of herniated liver and neonatal outcome
Objective We sought to use magnetic resonance (MR) imaging (MRI) to estimate percentage of fetal thorax occupied by lung, liver, and other abdominal organs in pregnancies with congenital diaphragmatic hernia (CDH). Study Design This was a retrospective study of pregnancies with isolated CDH referred...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 2009-03, Vol.200 (3), p.318.e1-318.e6 |
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| container_title | American journal of obstetrics and gynecology |
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| creator | Worley, Kevin C., MD Dashe, Jodi S., MD Barber, Robert G., RN Megison, Stephen M., MD McIntire, Donald D., PhD Twickler, Diane M., MD |
| description | Objective We sought to use magnetic resonance (MR) imaging (MRI) to estimate percentage of fetal thorax occupied by lung, liver, and other abdominal organs in pregnancies with congenital diaphragmatic hernia (CDH). Study Design This was a retrospective study of pregnancies with isolated CDH referred for MRI between August 2000 and June 2006. Four regions of interest were measured in the axial plane by an investigator blinded to neonatal outcome, and volumes were then calculated. The percentages of thorax occupied by lung, liver, and all herniated organs were then compared with neonatal outcomes. Results Fifteen CDH fetuses underwent MRI at a median gestational age of 29 weeks. Liver herniation was found in 93%. When the liver occupied > 20% of the fetal thorax, neonatal deaths were significantly increased. Percentages of lung and other herniated organs were not associated with outcome. Conclusion In our MR series of isolated CDH, neonatal deaths were significantly increased when > 20% of the fetal thorax was occupied by liver. |
| doi_str_mv | 10.1016/j.ajog.2008.10.008 |
| format | Article |
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Study Design This was a retrospective study of pregnancies with isolated CDH referred for MRI between August 2000 and June 2006. Four regions of interest were measured in the axial plane by an investigator blinded to neonatal outcome, and volumes were then calculated. The percentages of thorax occupied by lung, liver, and all herniated organs were then compared with neonatal outcomes. Results Fifteen CDH fetuses underwent MRI at a median gestational age of 29 weeks. Liver herniation was found in 93%. When the liver occupied > 20% of the fetal thorax, neonatal deaths were significantly increased. Percentages of lung and other herniated organs were not associated with outcome. Conclusion In our MR series of isolated CDH, neonatal deaths were significantly increased when > 20% of the fetal thorax was occupied by liver.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/j.ajog.2008.10.008</identifier><identifier>PMID: 19110232</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Aristolochia ; Biological and medical sciences ; Congenital diaphragmatic hernia ; Female ; Fetal Death - pathology ; Gynecology. Andrology. Obstetrics ; Hernia - congenital ; Hernia - mortality ; Hernia - pathology ; Hernia, Diaphragmatic - mortality ; Hernia, Diaphragmatic - pathology ; Hernias, Diaphragmatic, Congenital ; Humans ; Infant, Newborn ; Liver - pathology ; Magnetic Resonance Imaging ; Medical sciences ; Obstetrics and Gynecology ; Predictive Value of Tests ; Pregnancy ; Pregnancy Complications - mortality ; Pregnancy Complications - pathology ; Pregnancy Outcome ; prenatal diagnosis ; Prenatal Diagnosis - instrumentation ; Prenatal Diagnosis - methods ; Prognosis ; Retrospective Studies</subject><ispartof>American journal of obstetrics and gynecology, 2009-03, Vol.200 (3), p.318.e1-318.e6</ispartof><rights>Mosby, Inc.</rights><rights>2009 Mosby, Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-43ecf998669a06569a5cf6dee1a93d6133367e185e6004f2092bee88cff276543</citedby><cites>FETCH-LOGICAL-c505t-43ecf998669a06569a5cf6dee1a93d6133367e185e6004f2092bee88cff276543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ajog.2008.10.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21207462$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19110232$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Worley, Kevin C., MD</creatorcontrib><creatorcontrib>Dashe, Jodi S., MD</creatorcontrib><creatorcontrib>Barber, Robert G., RN</creatorcontrib><creatorcontrib>Megison, Stephen M., MD</creatorcontrib><creatorcontrib>McIntire, Donald D., PhD</creatorcontrib><creatorcontrib>Twickler, Diane M., MD</creatorcontrib><title>Fetal magnetic resonance imaging in isolated diaphragmatic hernia: volume of herniated liver and neonatal outcome</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Objective We sought to use magnetic resonance (MR) imaging (MRI) to estimate percentage of fetal thorax occupied by lung, liver, and other abdominal organs in pregnancies with congenital diaphragmatic hernia (CDH). Study Design This was a retrospective study of pregnancies with isolated CDH referred for MRI between August 2000 and June 2006. Four regions of interest were measured in the axial plane by an investigator blinded to neonatal outcome, and volumes were then calculated. The percentages of thorax occupied by lung, liver, and all herniated organs were then compared with neonatal outcomes. Results Fifteen CDH fetuses underwent MRI at a median gestational age of 29 weeks. Liver herniation was found in 93%. When the liver occupied > 20% of the fetal thorax, neonatal deaths were significantly increased. Percentages of lung and other herniated organs were not associated with outcome. Conclusion In our MR series of isolated CDH, neonatal deaths were significantly increased when > 20% of the fetal thorax was occupied by liver.</description><subject>Aristolochia</subject><subject>Biological and medical sciences</subject><subject>Congenital diaphragmatic hernia</subject><subject>Female</subject><subject>Fetal Death - pathology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Hernia - congenital</subject><subject>Hernia - mortality</subject><subject>Hernia - pathology</subject><subject>Hernia, Diaphragmatic - mortality</subject><subject>Hernia, Diaphragmatic - pathology</subject><subject>Hernias, Diaphragmatic, Congenital</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Liver - pathology</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical sciences</subject><subject>Obstetrics and Gynecology</subject><subject>Predictive Value of Tests</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - mortality</subject><subject>Pregnancy Complications - pathology</subject><subject>Pregnancy Outcome</subject><subject>prenatal diagnosis</subject><subject>Prenatal Diagnosis - instrumentation</subject><subject>Prenatal Diagnosis - methods</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ks-L1DAUx4Mo7jj6D3iQXPTW8SWdpomIIIu7Cgse1HPIpq-zqW0ym7QD-9-bMMUFD17yyJfv-5FPHiGvGewYMPF-2JkhHHYcQGZhl8MTsmGg2kpIIZ-SDQDwStWtvCAvUhrKlSv-nFwwxRjwmm_I_RXOZqSTOXicnaURU_DGW6Qua84fqPPUpTCaGTvaOXO8i-YwmeK9w-id-UBPYVwmpKFfleIc3QkjNb6jHnPB0iMssw0TviTPejMmfLXGLfl19eXn5dfq5vv1t8vPN5VtoJmrfY22V0oKoQyIJp-N7UWHyIyqO8HquhYtMtmgANj3HBS_RZTS9j1vRbOvt-Tdue4xhvsF06wnlyyOo8kTLUnnwko0mcKW8LPRxpBSxF4fY358fNAMdAGtB11A6wK6aDnkpDdr9eV2wu4xZSWbDW9Xg0nWjH3MUF366-OMQ7sXxffx7MPM4uQw6mQd5g_oXEQ76y64_8_x6Z90Ozrvcsff-IBpCEv0mbJmOnEN-kfZgbIRIIED4239B390saI</recordid><startdate>20090301</startdate><enddate>20090301</enddate><creator>Worley, Kevin C., MD</creator><creator>Dashe, Jodi S., MD</creator><creator>Barber, Robert G., RN</creator><creator>Megison, Stephen M., MD</creator><creator>McIntire, Donald D., PhD</creator><creator>Twickler, Diane M., MD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090301</creationdate><title>Fetal magnetic resonance imaging in isolated diaphragmatic hernia: volume of herniated liver and neonatal outcome</title><author>Worley, Kevin C., MD ; Dashe, Jodi S., MD ; Barber, Robert G., RN ; Megison, Stephen M., MD ; McIntire, Donald D., PhD ; Twickler, Diane M., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-43ecf998669a06569a5cf6dee1a93d6133367e185e6004f2092bee88cff276543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aristolochia</topic><topic>Biological and medical sciences</topic><topic>Congenital diaphragmatic hernia</topic><topic>Female</topic><topic>Fetal Death - pathology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Hernia - congenital</topic><topic>Hernia - mortality</topic><topic>Hernia - pathology</topic><topic>Hernia, Diaphragmatic - mortality</topic><topic>Hernia, Diaphragmatic - pathology</topic><topic>Hernias, Diaphragmatic, Congenital</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Liver - pathology</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical sciences</topic><topic>Obstetrics and Gynecology</topic><topic>Predictive Value of Tests</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - mortality</topic><topic>Pregnancy Complications - pathology</topic><topic>Pregnancy Outcome</topic><topic>prenatal diagnosis</topic><topic>Prenatal Diagnosis - instrumentation</topic><topic>Prenatal Diagnosis - methods</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Worley, Kevin C., MD</creatorcontrib><creatorcontrib>Dashe, Jodi S., MD</creatorcontrib><creatorcontrib>Barber, Robert G., RN</creatorcontrib><creatorcontrib>Megison, Stephen M., MD</creatorcontrib><creatorcontrib>McIntire, Donald D., PhD</creatorcontrib><creatorcontrib>Twickler, Diane M., MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Worley, Kevin C., MD</au><au>Dashe, Jodi S., MD</au><au>Barber, Robert G., RN</au><au>Megison, Stephen M., MD</au><au>McIntire, Donald D., PhD</au><au>Twickler, Diane M., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fetal magnetic resonance imaging in isolated diaphragmatic hernia: volume of herniated liver and neonatal outcome</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>2009-03-01</date><risdate>2009</risdate><volume>200</volume><issue>3</issue><spage>318.e1</spage><epage>318.e6</epage><pages>318.e1-318.e6</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Objective We sought to use magnetic resonance (MR) imaging (MRI) to estimate percentage of fetal thorax occupied by lung, liver, and other abdominal organs in pregnancies with congenital diaphragmatic hernia (CDH). Study Design This was a retrospective study of pregnancies with isolated CDH referred for MRI between August 2000 and June 2006. Four regions of interest were measured in the axial plane by an investigator blinded to neonatal outcome, and volumes were then calculated. The percentages of thorax occupied by lung, liver, and all herniated organs were then compared with neonatal outcomes. Results Fifteen CDH fetuses underwent MRI at a median gestational age of 29 weeks. Liver herniation was found in 93%. When the liver occupied > 20% of the fetal thorax, neonatal deaths were significantly increased. Percentages of lung and other herniated organs were not associated with outcome. Conclusion In our MR series of isolated CDH, neonatal deaths were significantly increased when > 20% of the fetal thorax was occupied by liver.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>19110232</pmid><doi>10.1016/j.ajog.2008.10.008</doi><tpages>3</tpages></addata></record> |
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| subjects | Aristolochia Biological and medical sciences Congenital diaphragmatic hernia Female Fetal Death - pathology Gynecology. Andrology. Obstetrics Hernia - congenital Hernia - mortality Hernia - pathology Hernia, Diaphragmatic - mortality Hernia, Diaphragmatic - pathology Hernias, Diaphragmatic, Congenital Humans Infant, Newborn Liver - pathology Magnetic Resonance Imaging Medical sciences Obstetrics and Gynecology Predictive Value of Tests Pregnancy Pregnancy Complications - mortality Pregnancy Complications - pathology Pregnancy Outcome prenatal diagnosis Prenatal Diagnosis - instrumentation Prenatal Diagnosis - methods Prognosis Retrospective Studies |
| title | Fetal magnetic resonance imaging in isolated diaphragmatic hernia: volume of herniated liver and neonatal outcome |
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