Suppressed T-cell activation by IFN-γ-induced expression of PD-L1 on renal tubular epithelial cells

Background. The interaction of the T-cell molecule PD-1 (programmed death-1) with its ligands PD-L1 and PD-L2 represents a known mechanism of T-cell inhibition. PD-1 is homologous to CD28 while the PD-1 ligands share homology with the B7 family of co-stimulatory molecules. Methods. We have studied s...

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