A New Pharmacological Effect of Salicylates: Inhibition of NFAT-Dependent Transcription

The anti-inflammatory effects of salicylates, originally attributed to inhibition of cyclooxygenase activity, are currently known to involve additional mechanisms. In this study we investigated the possible modulation by salicylates of NFAT-mediated transcription in lymphocytic and monocytic cell li...

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Veröffentlicht in:	The Journal of immunology (1950) 2004-11, Vol.173 (9), p.5721-5729
Hauptverfasser:	Aceves, Monica, Duenas, Ana, Gomez, Cristina, San Vicente, Edurne, Crespo, Mariano Sanchez, Garcia-Rodriguez, Carmen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Cell Line, Transformed Cell Line, Tumor Cells, Cultured Chemokines - antagonists & inhibitors Chemokines - biosynthesis Chemokines - genetics Cytokines - antagonists & inhibitors Cytokines - biosynthesis Cytokines - genetics DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Down-Regulation - drug effects Down-Regulation - immunology Gene Expression Regulation - drug effects Gene Expression Regulation - immunology Gene Silencing - drug effects Gene Silencing - immunology Granulocyte-Macrophage Colony-Stimulating Factor - antagonists & inhibitors Granulocyte-Macrophage Colony-Stimulating Factor - genetics Humans Interleukin-3 - antagonists & inhibitors Interleukin-3 - genetics Jurkat Cells Mice NFATC Transcription Factors Nuclear Proteins - antagonists & inhibitors Nuclear Proteins - genetics Nuclear Proteins - physiology Promoter Regions, Genetic - drug effects Promoter Regions, Genetic - immunology Salicylates - pharmacology Transcription Factors - antagonists & inhibitors Transcription Factors - genetics Transcription Factors - physiology Transcription, Genetic - drug effects Transcription, Genetic - immunology
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