Ethnic Differences in Genetic Polymorphisms of CYP2D6, CYP2C19, CYP3As and MDR1/ABCB1

Metabolic capacities for debrisoquin, sparteine, mephenytoin, nifedipine, and midazolam, which are substrates of polymorphic CYP2D6, CYP2C19, and CYP3A, have been reported to exhibit, in many cases, remarkable interindividual and ethnic differences. These ethnic differences are partly associated wit...

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Veröffentlicht in:	DRUG METABOLISM AND PHARMACOKINETICS 2004, Vol.19 (2), p.83-95
Hauptverfasser:	Ozawa, Shogo, Soyama, Akiko, Saeki, Mayumi, Fukushima-Uesaka, Hiromi, Itoda, Masaya, Koyano, Satoru, Sai, Kimie, Ohno, Yasuo, Saito, Yoshiro, Sawada, Jun-ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC transporter Aryl Hydrocarbon Hydroxylases - genetics ATP Binding Cassette Transporter 1 ATP-Binding Cassette Transporters - genetics Cytochrome P-450 CYP2C19 Cytochrome P-450 CYP2D6 - genetics Cytochrome P-450 CYP3A cytochrome P450 ethnic difference Ethnic Groups Genes, MDR - genetics genetic polymorphism Humans MDR1 Mixed Function Oxygenases - genetics Oxidation-Reduction Oxidoreductases, N-Demethylating - genetics Polymorphism, Genetic - genetics
Online-Zugang:	Volltext
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