Activation of the Cytokine Network and Unfavorable Outcome in Patients with Yellow Fever
To study the contribution of inflammatory mediators to the pathogenesis of yellow fever (YF), the serum levels of several cytokines and chemokines were measured in 7 patients with fatal YF (f-YF), 11 patients with nonfatal hemorrhagic YF (nf/h-YF), and 18 patients with nonfatal nonhemorrhagic YF (nf...
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| Veröffentlicht in: | The Journal of infectious diseases 2004-11, Vol.190 (10), p.1821-1827 |
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| creator | ter Meulen, Jan Sakho, Mohamed Koulemou, Kekoura Magassouba, N'Faly Bah, Aissatou Preiser, Wolfgang Daffis, Stephane Klewitz, Christian Bae, Hi-Gung Niedrig, Matthias Zeller, Hervé Heinzel-Gutenbrunner, Monika Koivogui, Lamine Kaufmann, Andreas |
| description | To study the contribution of inflammatory mediators to the pathogenesis of yellow fever (YF), the serum levels of several cytokines and chemokines were measured in 7 patients with fatal YF (f-YF), 11 patients with nonfatal hemorrhagic YF (nf/h-YF), and 18 patients with nonfatal nonhemorrhagic YF (nf/nh-YF). The levels of interleukin (IL)-6, monocyte chemoattractant protein-1, interferon-inducible protein (IP)-10, tumor necrosis factor-α, and IL-1 receptor antagonist (IL-1RA) were all statistically significantly higher in the patients with f-YF than in those with nf/nh-YF. In patients with nf/h-YF, only levels of IP-10 and IL-1RA were significantly elevated. The high levels of pro- and anti-inflammatory cytokines and chemokines in serum from patients with f-YF are reminiscent of those seen in patients with bacterial sepsis. This finding has implications for the understanding of the pathophysiology of YF and the development of therapeutic strategies. |
| doi_str_mv | 10.1086/425016 |
| format | Article |
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The levels of interleukin (IL)-6, monocyte chemoattractant protein-1, interferon-inducible protein (IP)-10, tumor necrosis factor-α, and IL-1 receptor antagonist (IL-1RA) were all statistically significantly higher in the patients with f-YF than in those with nf/nh-YF. In patients with nf/h-YF, only levels of IP-10 and IL-1RA were significantly elevated. The high levels of pro- and anti-inflammatory cytokines and chemokines in serum from patients with f-YF are reminiscent of those seen in patients with bacterial sepsis. This finding has implications for the understanding of the pathophysiology of YF and the development of therapeutic strategies.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/425016</identifier><identifier>PMID: 15499539</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adolescent ; Adult ; Aged ; Antibodies ; Arboviroses ; Biological and medical sciences ; Chemokine CCL2 - blood ; Chemokine CXCL10 ; Chemokines ; Chemokines, CXC - blood ; Child ; Child, Preschool ; Cytokines ; Cytokines - blood ; Cytokines - immunology ; Epidemics ; Female ; Fundamental and applied biological sciences. Psychology ; Guinea ; Hemorrhage ; Human viral diseases ; Humans ; Infections ; Infectious diseases ; Inflammation Mediators - blood ; Inflammation Mediators - immunology ; Interleukin 1 Receptor Antagonist Protein ; Interleukin-6 - blood ; Male ; Medical sciences ; Microbiology ; Middle Aged ; Polymerase chain reaction ; Reverse transcriptase polymerase chain reaction ; Sialoglycoproteins - blood ; Tropical viral diseases ; Tumor Necrosis Factor-alpha - analysis ; Viral diseases ; Viremia ; Virues ; Viruses ; Yellow fever ; Yellow Fever - immunology ; Yellow Fever - pathology ; Yellow Fever - physiopathology</subject><ispartof>The Journal of infectious diseases, 2004-11, Vol.190 (10), p.1821-1827</ispartof><rights>Copyright 2004 Infectious Diseases Society of America</rights><rights>2004 by the Infectious Diseases Society of America 2004</rights><rights>2005 INIST-CNRS</rights><rights>Copyright University of Chicago Press Nov 15, 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-40f0e7a9cea18f30ea144f8bdade0b3ae07b151c3e1f69d0f5f2efe7a6229a5f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30077955$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30077955$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16313771$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15499539$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ter Meulen, Jan</creatorcontrib><creatorcontrib>Sakho, Mohamed</creatorcontrib><creatorcontrib>Koulemou, Kekoura</creatorcontrib><creatorcontrib>Magassouba, N'Faly</creatorcontrib><creatorcontrib>Bah, Aissatou</creatorcontrib><creatorcontrib>Preiser, Wolfgang</creatorcontrib><creatorcontrib>Daffis, Stephane</creatorcontrib><creatorcontrib>Klewitz, Christian</creatorcontrib><creatorcontrib>Bae, Hi-Gung</creatorcontrib><creatorcontrib>Niedrig, Matthias</creatorcontrib><creatorcontrib>Zeller, Hervé</creatorcontrib><creatorcontrib>Heinzel-Gutenbrunner, Monika</creatorcontrib><creatorcontrib>Koivogui, Lamine</creatorcontrib><creatorcontrib>Kaufmann, Andreas</creatorcontrib><title>Activation of the Cytokine Network and Unfavorable Outcome in Patients with Yellow Fever</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>To study the contribution of inflammatory mediators to the pathogenesis of yellow fever (YF), the serum levels of several cytokines and chemokines were measured in 7 patients with fatal YF (f-YF), 11 patients with nonfatal hemorrhagic YF (nf/h-YF), and 18 patients with nonfatal nonhemorrhagic YF (nf/nh-YF). The levels of interleukin (IL)-6, monocyte chemoattractant protein-1, interferon-inducible protein (IP)-10, tumor necrosis factor-α, and IL-1 receptor antagonist (IL-1RA) were all statistically significantly higher in the patients with f-YF than in those with nf/nh-YF. In patients with nf/h-YF, only levels of IP-10 and IL-1RA were significantly elevated. The high levels of pro- and anti-inflammatory cytokines and chemokines in serum from patients with f-YF are reminiscent of those seen in patients with bacterial sepsis. This finding has implications for the understanding of the pathophysiology of YF and the development of therapeutic strategies.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Antibodies</subject><subject>Arboviroses</subject><subject>Biological and medical sciences</subject><subject>Chemokine CCL2 - blood</subject><subject>Chemokine CXCL10</subject><subject>Chemokines</subject><subject>Chemokines, CXC - blood</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cytokines</subject><subject>Cytokines - blood</subject><subject>Cytokines - immunology</subject><subject>Epidemics</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Guinea</subject><subject>Hemorrhage</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Inflammation Mediators - blood</subject><subject>Inflammation Mediators - immunology</subject><subject>Interleukin 1 Receptor Antagonist Protein</subject><subject>Interleukin-6 - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Polymerase chain reaction</subject><subject>Reverse transcriptase polymerase chain reaction</subject><subject>Sialoglycoproteins - blood</subject><subject>Tropical viral diseases</subject><subject>Tumor Necrosis Factor-alpha - analysis</subject><subject>Viral diseases</subject><subject>Viremia</subject><subject>Virues</subject><subject>Viruses</subject><subject>Yellow fever</subject><subject>Yellow Fever - immunology</subject><subject>Yellow Fever - pathology</subject><subject>Yellow Fever - physiopathology</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV9v0zAUxS0EYmXANwCZSfAWsOPYjh-3irGhivHApMGL5STXWtrULrbTsm-Pp1SrNAnxdB_O75775yD0mpKPlNTiU1VyQsUTNKOcyUIIyp6iGSFlWdBaqSP0IsYlIaRiQj5HR5RXSnGmZujmtE391qTeO-wtTreA53fJr3oH-BuknQ8rbFyHr501Wx9MMwC-GlPr14B7h7_nTnAp4l2fbvFPGAa_w-ewhfASPbNmiPBqX4_R9fnnH_OLYnH15XJ-uijaqqapqIglII1qwdDaMpJLVdm66UwHpGEGiGwopy0DaoXqiOW2BJs7RFkqwy07Rh8m303wv0eISa_72OZFjAM_Ri2EUkzV9L8glZKxksoMnjwCl34MLh-hy5IpIgWtD25t8DEGsHoT-rUJd5oSfZ-InhLJ4Nu929isoTtg-wgy8H4PmNiawQbj2j4eOMEok_J-_3cT58fNv4e9mZhlTD48UIwQKRXnWS8mvY8J_jzoJqy0kExyfXHzS-d_1YtFdaa_sr_V17Sb</recordid><startdate>20041115</startdate><enddate>20041115</enddate><creator>ter Meulen, Jan</creator><creator>Sakho, Mohamed</creator><creator>Koulemou, Kekoura</creator><creator>Magassouba, N'Faly</creator><creator>Bah, Aissatou</creator><creator>Preiser, Wolfgang</creator><creator>Daffis, Stephane</creator><creator>Klewitz, Christian</creator><creator>Bae, Hi-Gung</creator><creator>Niedrig, Matthias</creator><creator>Zeller, Hervé</creator><creator>Heinzel-Gutenbrunner, Monika</creator><creator>Koivogui, Lamine</creator><creator>Kaufmann, Andreas</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20041115</creationdate><title>Activation of the Cytokine Network and Unfavorable Outcome in Patients with Yellow Fever</title><author>ter Meulen, Jan ; Sakho, Mohamed ; Koulemou, Kekoura ; Magassouba, N'Faly ; Bah, Aissatou ; Preiser, Wolfgang ; Daffis, Stephane ; Klewitz, Christian ; Bae, Hi-Gung ; Niedrig, Matthias ; Zeller, Hervé ; Heinzel-Gutenbrunner, Monika ; Koivogui, Lamine ; Kaufmann, Andreas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-40f0e7a9cea18f30ea144f8bdade0b3ae07b151c3e1f69d0f5f2efe7a6229a5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Antibodies</topic><topic>Arboviroses</topic><topic>Biological and medical sciences</topic><topic>Chemokine CCL2 - blood</topic><topic>Chemokine CXCL10</topic><topic>Chemokines</topic><topic>Chemokines, CXC - blood</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cytokines</topic><topic>Cytokines - blood</topic><topic>Cytokines - immunology</topic><topic>Epidemics</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Guinea</topic><topic>Hemorrhage</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Inflammation Mediators - blood</topic><topic>Inflammation Mediators - immunology</topic><topic>Interleukin 1 Receptor Antagonist Protein</topic><topic>Interleukin-6 - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Polymerase chain reaction</topic><topic>Reverse transcriptase polymerase chain reaction</topic><topic>Sialoglycoproteins - blood</topic><topic>Tropical viral diseases</topic><topic>Tumor Necrosis Factor-alpha - analysis</topic><topic>Viral diseases</topic><topic>Viremia</topic><topic>Virues</topic><topic>Viruses</topic><topic>Yellow fever</topic><topic>Yellow Fever - immunology</topic><topic>Yellow Fever - pathology</topic><topic>Yellow Fever - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ter Meulen, Jan</creatorcontrib><creatorcontrib>Sakho, Mohamed</creatorcontrib><creatorcontrib>Koulemou, Kekoura</creatorcontrib><creatorcontrib>Magassouba, N'Faly</creatorcontrib><creatorcontrib>Bah, Aissatou</creatorcontrib><creatorcontrib>Preiser, Wolfgang</creatorcontrib><creatorcontrib>Daffis, Stephane</creatorcontrib><creatorcontrib>Klewitz, Christian</creatorcontrib><creatorcontrib>Bae, Hi-Gung</creatorcontrib><creatorcontrib>Niedrig, Matthias</creatorcontrib><creatorcontrib>Zeller, Hervé</creatorcontrib><creatorcontrib>Heinzel-Gutenbrunner, Monika</creatorcontrib><creatorcontrib>Koivogui, Lamine</creatorcontrib><creatorcontrib>Kaufmann, Andreas</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ter Meulen, Jan</au><au>Sakho, Mohamed</au><au>Koulemou, Kekoura</au><au>Magassouba, N'Faly</au><au>Bah, Aissatou</au><au>Preiser, Wolfgang</au><au>Daffis, Stephane</au><au>Klewitz, Christian</au><au>Bae, Hi-Gung</au><au>Niedrig, Matthias</au><au>Zeller, Hervé</au><au>Heinzel-Gutenbrunner, Monika</au><au>Koivogui, Lamine</au><au>Kaufmann, Andreas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activation of the Cytokine Network and Unfavorable Outcome in Patients with Yellow Fever</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2004-11-15</date><risdate>2004</risdate><volume>190</volume><issue>10</issue><spage>1821</spage><epage>1827</epage><pages>1821-1827</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>To study the contribution of inflammatory mediators to the pathogenesis of yellow fever (YF), the serum levels of several cytokines and chemokines were measured in 7 patients with fatal YF (f-YF), 11 patients with nonfatal hemorrhagic YF (nf/h-YF), and 18 patients with nonfatal nonhemorrhagic YF (nf/nh-YF). The levels of interleukin (IL)-6, monocyte chemoattractant protein-1, interferon-inducible protein (IP)-10, tumor necrosis factor-α, and IL-1 receptor antagonist (IL-1RA) were all statistically significantly higher in the patients with f-YF than in those with nf/nh-YF. In patients with nf/h-YF, only levels of IP-10 and IL-1RA were significantly elevated. The high levels of pro- and anti-inflammatory cytokines and chemokines in serum from patients with f-YF are reminiscent of those seen in patients with bacterial sepsis. This finding has implications for the understanding of the pathophysiology of YF and the development of therapeutic strategies.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>15499539</pmid><doi>10.1086/425016</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of infectious diseases, 2004-11, Vol.190 (10), p.1821-1827 |
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| source | Jstor Complete Legacy; MEDLINE; Oxford Academic Journals (OUP); Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Antibodies Arboviroses Biological and medical sciences Chemokine CCL2 - blood Chemokine CXCL10 Chemokines Chemokines, CXC - blood Child Child, Preschool Cytokines Cytokines - blood Cytokines - immunology Epidemics Female Fundamental and applied biological sciences. Psychology Guinea Hemorrhage Human viral diseases Humans Infections Infectious diseases Inflammation Mediators - blood Inflammation Mediators - immunology Interleukin 1 Receptor Antagonist Protein Interleukin-6 - blood Male Medical sciences Microbiology Middle Aged Polymerase chain reaction Reverse transcriptase polymerase chain reaction Sialoglycoproteins - blood Tropical viral diseases Tumor Necrosis Factor-alpha - analysis Viral diseases Viremia Virues Viruses Yellow fever Yellow Fever - immunology Yellow Fever - pathology Yellow Fever - physiopathology |
| title | Activation of the Cytokine Network and Unfavorable Outcome in Patients with Yellow Fever |
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