Steroidal glycosides from the bulbs of Ornithogalum thyrsoides
Phytochemical analyses have been carried out on the fresh bulbs of Ornithogalum thyrsoides with particular attention to the steroidal glycoside constituents, resulting in the isolation of four new spirostanol saponins and seven new cholestane glycosides, together with three known steroidal compounds...
Gespeichert in:
| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2004-10, Vol.67 (10), p.1690-1696 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1696 |
|---|---|
| container_issue | 10 |
| container_start_page | 1690 |
| container_title | Journal of natural products (Washington, D.C.) |
| container_volume | 67 |
| creator | Kuroda, Minpei Mimaki, Yoshihiro Ori, Kazutomo Sakagami, Hiroshi Sashida, Yutaka |
| description | Phytochemical analyses have been carried out on the fresh bulbs of Ornithogalum thyrsoides with particular attention to the steroidal glycoside constituents, resulting in the isolation of four new spirostanol saponins and seven new cholestane glycosides, together with three known steroidal compounds. The structures of the new glycosides were determined on the basis of their spectroscopic data, including 2D NMR spectroscopy, and the results of hydrolytic cleavage. The isolated compounds were evaluated for their cytotoxic activities against HL-60 human promyelocytic leukemia cells and HSC-2 human oral squamous cell carcinoma cells. |
| doi_str_mv | 10.1021/np040108i |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_66993685</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>66993685</sourcerecordid><originalsourceid>FETCH-LOGICAL-p139t-a930cd8b39534c8302cee34b4870bbe49250f98e1752150f0df4962f115fda833</originalsourceid><addsrcrecordid>eNo1jz1PwzAURT2AaCkM_AGUiS3wnGcn9oKEKr6kSh2AObJjuw1y4mAnQ_49rSjTPdI9utIl5IbCPYWCPvQDMKAg2jOyBFpijqJkC3KZ0jcAIEh-QRaUM1lJRpfk8WO0MbRG-Wzn5yak1tiUuRi6bNzbTE9epyy4bBv7dtyHnfLTsZljCkfzipw75ZO9PuWKfL08f67f8s329X39tMkHinLMlURojNAoObJGIBSNtcg0ExVobZksODgpLK14QQ8IxjFZFo5S7owSiCty97c7xPAz2TTWXZsa673qbZhSXZZSYin4Qbw9iZPurKmH2HYqzvX_Y_wFmg9U9A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>66993685</pqid></control><display><type>article</type><title>Steroidal glycosides from the bulbs of Ornithogalum thyrsoides</title><source>ACS Publications</source><source>MEDLINE</source><creator>Kuroda, Minpei ; Mimaki, Yoshihiro ; Ori, Kazutomo ; Sakagami, Hiroshi ; Sashida, Yutaka</creator><creatorcontrib>Kuroda, Minpei ; Mimaki, Yoshihiro ; Ori, Kazutomo ; Sakagami, Hiroshi ; Sashida, Yutaka</creatorcontrib><description>Phytochemical analyses have been carried out on the fresh bulbs of Ornithogalum thyrsoides with particular attention to the steroidal glycoside constituents, resulting in the isolation of four new spirostanol saponins and seven new cholestane glycosides, together with three known steroidal compounds. The structures of the new glycosides were determined on the basis of their spectroscopic data, including 2D NMR spectroscopy, and the results of hydrolytic cleavage. The isolated compounds were evaluated for their cytotoxic activities against HL-60 human promyelocytic leukemia cells and HSC-2 human oral squamous cell carcinoma cells.</description><identifier>ISSN: 0163-3864</identifier><identifier>DOI: 10.1021/np040108i</identifier><identifier>PMID: 15497941</identifier><language>eng</language><publisher>United States</publisher><subject>Antineoplastic Agents, Phytogenic - chemistry ; Antineoplastic Agents, Phytogenic - isolation & purification ; Antineoplastic Agents, Phytogenic - pharmacology ; Drug Screening Assays, Antitumor ; Glycosides - chemistry ; Glycosides - isolation & purification ; Glycosides - pharmacology ; Humans ; Japan ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular ; Ornithogalum - chemistry ; Plant Roots - chemistry ; Plants, Medicinal - chemistry ; Steroids - chemistry ; Steroids - isolation & purification ; Steroids - pharmacology ; Tumor Cells, Cultured</subject><ispartof>Journal of natural products (Washington, D.C.), 2004-10, Vol.67 (10), p.1690-1696</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15497941$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuroda, Minpei</creatorcontrib><creatorcontrib>Mimaki, Yoshihiro</creatorcontrib><creatorcontrib>Ori, Kazutomo</creatorcontrib><creatorcontrib>Sakagami, Hiroshi</creatorcontrib><creatorcontrib>Sashida, Yutaka</creatorcontrib><title>Steroidal glycosides from the bulbs of Ornithogalum thyrsoides</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J Nat Prod</addtitle><description>Phytochemical analyses have been carried out on the fresh bulbs of Ornithogalum thyrsoides with particular attention to the steroidal glycoside constituents, resulting in the isolation of four new spirostanol saponins and seven new cholestane glycosides, together with three known steroidal compounds. The structures of the new glycosides were determined on the basis of their spectroscopic data, including 2D NMR spectroscopy, and the results of hydrolytic cleavage. The isolated compounds were evaluated for their cytotoxic activities against HL-60 human promyelocytic leukemia cells and HSC-2 human oral squamous cell carcinoma cells.</description><subject>Antineoplastic Agents, Phytogenic - chemistry</subject><subject>Antineoplastic Agents, Phytogenic - isolation & purification</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Glycosides - chemistry</subject><subject>Glycosides - isolation & purification</subject><subject>Glycosides - pharmacology</subject><subject>Humans</subject><subject>Japan</subject><subject>Molecular Structure</subject><subject>Nuclear Magnetic Resonance, Biomolecular</subject><subject>Ornithogalum - chemistry</subject><subject>Plant Roots - chemistry</subject><subject>Plants, Medicinal - chemistry</subject><subject>Steroids - chemistry</subject><subject>Steroids - isolation & purification</subject><subject>Steroids - pharmacology</subject><subject>Tumor Cells, Cultured</subject><issn>0163-3864</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1jz1PwzAURT2AaCkM_AGUiS3wnGcn9oKEKr6kSh2AObJjuw1y4mAnQ_49rSjTPdI9utIl5IbCPYWCPvQDMKAg2jOyBFpijqJkC3KZ0jcAIEh-QRaUM1lJRpfk8WO0MbRG-Wzn5yak1tiUuRi6bNzbTE9epyy4bBv7dtyHnfLTsZljCkfzipw75ZO9PuWKfL08f67f8s329X39tMkHinLMlURojNAoObJGIBSNtcg0ExVobZksODgpLK14QQ8IxjFZFo5S7owSiCty97c7xPAz2TTWXZsa673qbZhSXZZSYin4Qbw9iZPurKmH2HYqzvX_Y_wFmg9U9A</recordid><startdate>200410</startdate><enddate>200410</enddate><creator>Kuroda, Minpei</creator><creator>Mimaki, Yoshihiro</creator><creator>Ori, Kazutomo</creator><creator>Sakagami, Hiroshi</creator><creator>Sashida, Yutaka</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200410</creationdate><title>Steroidal glycosides from the bulbs of Ornithogalum thyrsoides</title><author>Kuroda, Minpei ; Mimaki, Yoshihiro ; Ori, Kazutomo ; Sakagami, Hiroshi ; Sashida, Yutaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p139t-a930cd8b39534c8302cee34b4870bbe49250f98e1752150f0df4962f115fda833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Antineoplastic Agents, Phytogenic - chemistry</topic><topic>Antineoplastic Agents, Phytogenic - isolation & purification</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Glycosides - chemistry</topic><topic>Glycosides - isolation & purification</topic><topic>Glycosides - pharmacology</topic><topic>Humans</topic><topic>Japan</topic><topic>Molecular Structure</topic><topic>Nuclear Magnetic Resonance, Biomolecular</topic><topic>Ornithogalum - chemistry</topic><topic>Plant Roots - chemistry</topic><topic>Plants, Medicinal - chemistry</topic><topic>Steroids - chemistry</topic><topic>Steroids - isolation & purification</topic><topic>Steroids - pharmacology</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuroda, Minpei</creatorcontrib><creatorcontrib>Mimaki, Yoshihiro</creatorcontrib><creatorcontrib>Ori, Kazutomo</creatorcontrib><creatorcontrib>Sakagami, Hiroshi</creatorcontrib><creatorcontrib>Sashida, Yutaka</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuroda, Minpei</au><au>Mimaki, Yoshihiro</au><au>Ori, Kazutomo</au><au>Sakagami, Hiroshi</au><au>Sashida, Yutaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Steroidal glycosides from the bulbs of Ornithogalum thyrsoides</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J Nat Prod</addtitle><date>2004-10</date><risdate>2004</risdate><volume>67</volume><issue>10</issue><spage>1690</spage><epage>1696</epage><pages>1690-1696</pages><issn>0163-3864</issn><abstract>Phytochemical analyses have been carried out on the fresh bulbs of Ornithogalum thyrsoides with particular attention to the steroidal glycoside constituents, resulting in the isolation of four new spirostanol saponins and seven new cholestane glycosides, together with three known steroidal compounds. The structures of the new glycosides were determined on the basis of their spectroscopic data, including 2D NMR spectroscopy, and the results of hydrolytic cleavage. The isolated compounds were evaluated for their cytotoxic activities against HL-60 human promyelocytic leukemia cells and HSC-2 human oral squamous cell carcinoma cells.</abstract><cop>United States</cop><pmid>15497941</pmid><doi>10.1021/np040108i</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-3864 |
| ispartof | Journal of natural products (Washington, D.C.), 2004-10, Vol.67 (10), p.1690-1696 |
| issn | 0163-3864 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_66993685 |
| source | ACS Publications; MEDLINE |
| subjects | Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Drug Screening Assays, Antitumor Glycosides - chemistry Glycosides - isolation & purification Glycosides - pharmacology Humans Japan Molecular Structure Nuclear Magnetic Resonance, Biomolecular Ornithogalum - chemistry Plant Roots - chemistry Plants, Medicinal - chemistry Steroids - chemistry Steroids - isolation & purification Steroids - pharmacology Tumor Cells, Cultured |
| title | Steroidal glycosides from the bulbs of Ornithogalum thyrsoides |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T22%3A24%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Steroidal%20glycosides%20from%20the%20bulbs%20of%20Ornithogalum%20thyrsoides&rft.jtitle=Journal%20of%20natural%20products%20(Washington,%20D.C.)&rft.au=Kuroda,%20Minpei&rft.date=2004-10&rft.volume=67&rft.issue=10&rft.spage=1690&rft.epage=1696&rft.pages=1690-1696&rft.issn=0163-3864&rft_id=info:doi/10.1021/np040108i&rft_dat=%3Cproquest_pubme%3E66993685%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=66993685&rft_id=info:pmid/15497941&rfr_iscdi=true |