Rapid Induction of Splenic and Peritoneal B-1a Cells in Adult Mice by Thymus-Independent Type-2 Antigen

We have produced a transgenic mouse (PV1TgL) that can only generate B lymphocytes with an Ig receptor specific for the synthetic polymer polyvinyl pyrrolidinone. Before immunization, bone marrow B cell numbers are very low, and peripheral lymphoid organs are almost devoid of B cells, confirming the...

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Veröffentlicht in:	The Journal of immunology (1950) 2004-11, Vol.173 (9), p.5406-5414
Hauptverfasser:	Whitmore, Alan C, Neely, Harold R, Diz, Ramiro, Flood, Patrick M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - genetics Aging - immunology Animals Antibody Formation - genetics Antigens, T-Independent - administration & dosage Antigens, T-Independent - immunology B-Lymphocyte Subsets - cytology B-Lymphocyte Subsets - immunology Cell Differentiation - genetics Cell Differentiation - immunology Crosses, Genetic Female Immunization - methods Immunophenotyping Lymphocyte Activation - genetics Lymphocyte Activation - immunology Lymphocyte Count Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Peritoneum - cytology Peritoneum - immunology Povidone - administration & dosage Povidone - analogs & derivatives Spleen - cytology Spleen - immunology
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