The Organic Anion Transporter (OATP) Family
In the last decade, many organic anion transporters have been isolated, characterized their distribution and substrates. The recently identified organic anion transporter family OATP (organic anion transporting polypeptide)/LST (liver-specific transporter) family, transport bile acids, hormones as w...
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| Veröffentlicht in: | DRUG METABOLISM AND PHARMACOKINETICS 2004, Vol.19 (3), p.171-179 |
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| container_title | DRUG METABOLISM AND PHARMACOKINETICS |
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| creator | Mikkaichi, Tsuyoshi Suzuki, Takehiro Tanemoto, Masayuki Ito, Sadayoshi Abe, Takaaki |
| description | In the last decade, many organic anion transporters have been isolated, characterized their distribution and substrates. The recently identified organic anion transporter family OATP (organic anion transporting polypeptide)/LST (liver-specific transporter) family, transport bile acids, hormones as well as eicosanoids, various compounds (BSP, HMG-CoA reductase inhibitor, angiotensin converting enzyme inhibitor, etc.). The isolation of the family revealed that not only hydrophilic compounds, drugs and hormones of lipophilic nature need a membrane transport system to penetrate cell membrane. In this family, the nomenclature becomes very complicated and the physiological role of this family is still unclear except about few organs such as the brain, liver and kidney. Even in such organs, the coexistence of the OATP/LST family and similar substrate specificity hamper the progress and clear characterization identifying the real role of the transporter family. Here, recent progress and an insight of this field are reviewed. |
| doi_str_mv | 10.2133/dmpk.19.171 |
| format | Article |
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Here, recent progress and an insight of this field are reviewed.</description><subject>Animals</subject><subject>Humans</subject><subject>Organic Anion Transporters - classification</subject><subject>Organic Anion Transporters - genetics</subject><subject>Organic Anion Transporters - metabolism</subject><subject>Organic Anion Transporters - physiology</subject><subject>Pharmaceutical Preparations - metabolism</subject><subject>Phylogeny</subject><issn>1347-4367</issn><issn>1880-0920</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkM9LIzEUx4O4rK7uybvMSVxkui8_ZjI5lmJVELqH7jkkaaKpM0lNpkL_e1Na8OLlvQfvw4f3vghdYZgQTOnf1bB5m2AxwRyfoHPcdVCDIHBaZsp4zWjLz9CvnNcAlDaM_ERnuGFC4I6do7vlq60W6UUFb6pp8DFUy6RC3sQ02lTdLqbLf3-quRp8v7tEP5zqs_197Bfo__x-OXusnxcPT7Ppc20aIGPNms4IBk3rOtcZZZw1XLGudVxrwk2jHSa205w5AWUGrtoVp1o7KBc5pukFujl4Nym-b20e5eCzsX2vgo3bLNtWCILbtoB3B9CkmHOyTm6SH1TaSQxyn43cZyOxkCWbQl8ftVs92NUXewyjAPMDULbeqD6G3gcr13GbQvlXmogHOyotCQCTAFgALY1IKPp9EaLBjIoiag4iW1L68DbJbLwNpmiTNaNcRf_thZ_QcYaH</recordid><startdate>2004</startdate><enddate>2004</enddate><creator>Mikkaichi, Tsuyoshi</creator><creator>Suzuki, Takehiro</creator><creator>Tanemoto, Masayuki</creator><creator>Ito, Sadayoshi</creator><creator>Abe, Takaaki</creator><general>Elsevier Ltd</general><general>Japanese Society for the Study of Xenobiotics</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2004</creationdate><title>The Organic Anion Transporter (OATP) Family</title><author>Mikkaichi, Tsuyoshi ; Suzuki, Takehiro ; Tanemoto, Masayuki ; Ito, Sadayoshi ; Abe, Takaaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-458c94056f8f8cacfec7a486f7bb27c5bf12e8b74f90bf107a6d73bbf0184f4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Humans</topic><topic>Organic Anion Transporters - classification</topic><topic>Organic Anion Transporters - genetics</topic><topic>Organic Anion Transporters - metabolism</topic><topic>Organic Anion Transporters - physiology</topic><topic>Pharmaceutical Preparations - metabolism</topic><topic>Phylogeny</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mikkaichi, Tsuyoshi</creatorcontrib><creatorcontrib>Suzuki, Takehiro</creatorcontrib><creatorcontrib>Tanemoto, Masayuki</creatorcontrib><creatorcontrib>Ito, Sadayoshi</creatorcontrib><creatorcontrib>Abe, Takaaki</creatorcontrib><creatorcontrib>century COE program</creatorcontrib><creatorcontrib>Tohoku University Graduate School of Medicine</creatorcontrib><creatorcontrib>Department of Clinical Pharmacy</creatorcontrib><creatorcontrib>Department of Medicine</creatorcontrib><creatorcontrib>Endocrinology</creatorcontrib><creatorcontrib>Division of Nephrology</creatorcontrib><creatorcontrib>PRESTO</creatorcontrib><creatorcontrib>and Vascular Medicine</creatorcontrib><creatorcontrib>Japan Science and Technology Agency (JST</creatorcontrib><creatorcontrib>Tohoku University Graduate School of Pharmaceutical Sciences</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>DRUG METABOLISM AND PHARMACOKINETICS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mikkaichi, Tsuyoshi</au><au>Suzuki, Takehiro</au><au>Tanemoto, Masayuki</au><au>Ito, Sadayoshi</au><au>Abe, Takaaki</au><aucorp>century COE program</aucorp><aucorp>Tohoku University Graduate School of Medicine</aucorp><aucorp>Department of Clinical Pharmacy</aucorp><aucorp>Department of Medicine</aucorp><aucorp>Endocrinology</aucorp><aucorp>Division of Nephrology</aucorp><aucorp>PRESTO</aucorp><aucorp>and Vascular Medicine</aucorp><aucorp>Japan Science and Technology Agency (JST</aucorp><aucorp>Tohoku University Graduate School of Pharmaceutical Sciences</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Organic Anion Transporter (OATP) Family</atitle><jtitle>DRUG METABOLISM AND PHARMACOKINETICS</jtitle><addtitle>Drug Metab Pharmacokinet</addtitle><date>2004</date><risdate>2004</risdate><volume>19</volume><issue>3</issue><spage>171</spage><epage>179</epage><pages>171-179</pages><issn>1347-4367</issn><eissn>1880-0920</eissn><abstract>In the last decade, many organic anion transporters have been isolated, characterized their distribution and substrates. 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| source | J-STAGE Free; MEDLINE; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Animals Humans Organic Anion Transporters - classification Organic Anion Transporters - genetics Organic Anion Transporters - metabolism Organic Anion Transporters - physiology Pharmaceutical Preparations - metabolism Phylogeny |
| title | The Organic Anion Transporter (OATP) Family |
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