p53 represses c-Myc through induction of the tumor suppressor miR-145

The tumor suppressor p53 negatively regulates a number of genes, including the proto-oncogene c-Myc, in addition to activating many other genes. One mechanism of the p53-mediated c-Myc repression may involve transcriptional regulation. However, it is not clear whether microRNAs (miRNAs) play a role...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-03, Vol.106 (9), p.3207-3212
Hauptverfasser:	Sachdeva, Mohit, Zhu, Shoumin, Wu, Fangting, Wu, Hailong, Walia, Vijay, Kumar, Sumit, Elble, Randolph, Watabe, Kounosuke, Mo, Yin-Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Cell cycle Cell growth Cell Line, Tumor Cell lines Cell Proliferation Directional control Gene expression Gene Expression Regulation Genes HCT116 cells Humans MicroRNA MicroRNAs - genetics Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Repression Response Elements - genetics Signal Transduction Studies Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors
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