Claudin-3 gene silencing with siRNA suppresses ovarian tumor growth and metastasis

Claudin-3 (CLDN3) is a tight junction protein that is overexpressed in 90% of ovarian tumors. Previous in vitro studies have indicated that CLDN3 overexpression promotes the migration, invasion, and survival of ovarian cancer cells. Here, we investigated the efficacy of lipidoid-formulated CLDN3 siR...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-03, Vol.106 (9), p.3426-3430
Hauptverfasser:	Huang, Yu-Hung, Bao, Yunhua, Peng, Weidan, Goldberg, Michael, Love, Kevin, Bumcrot, David A, Cole, Geoffrey, Langer, Robert, Anderson, Daniel G, Sawicki, Janet A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Cancer Cell Line, Tumor Cell lines Cells Claudin-3 Disease Models, Animal Disease Progression Epithelial cells Female Gene expression Gene Expression Regulation, Neoplastic Heterologous transplantation Humans Medical treatment Membrane proteins Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Inbred BALB C Mice, Nude Neoplasm Metastasis - pathology Ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Proteins Ribonucleic acid RNA RNA, Small Interfering - genetics Rodents Small interfering RNA Tumor burden Tumors Xenograft Model Antitumor Assays
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