KI-67 Antigen Expression Predicts Survival and Correlates with Histologic Subtype in the WHO Classification of Thymic Epithelial Tumors
We performed an immunohistochemical study with monoclonal antibodies to Ki-67 antigen and p53 protein on 45 cases of thymic epithelial tumors classified according to the recent World Health Organization (WHO) classification system to evaluate whether there is correlation between the expression of th...
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| Veröffentlicht in: | International journal of surgical pathology 2004-10, Vol.12 (4), p.395-400 |
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| creator | Comin, Camilla E. Messerini, Luca Novelli, Luca Boddi, Vieri Dini, Sergio |
| description | We performed an immunohistochemical study with monoclonal antibodies to Ki-67 antigen and p53 protein on 45 cases of thymic epithelial tumors classified according to the recent World Health Organization (WHO) classification system to evaluate whether there is correlation between the expression of these markers and prognosis, histologic subtype, and myasthenia gravis (MG). We also correlated histologic subtype with sex, age, MG, and survival. Ki-67 and p53 labeling indices (LIs) were expressed as a percentage of positive nuclear immunostaining by counting 1,000 epithelial tumor cells. Statistically significant differences were found between Ki-67 LI and survival (p = 0.007), whereas the prognostic implication of p53 could not be demonstrated, although there appeared a trend that patients with tumors of higher LIs had worse survival. Significant correlations were also found between Ki-67 (p < 0.0005) and p53 (p < 0.0005) LIs and histologic subtypes. No correlation was found between these parameters and MG. Histologic subtypes of the WHO classification also correlated with survival (p = 0.01), whereas no correlation was found with sex, age, and MG. In conclusion, our results indicate that the proliferative activity, assessed by Ki-67 LI, and the histologic pattern, according to WHO classification system, seems to represent reliable parameters in the prognosis of thymic epithelial tumors. |
| doi_str_mv | 10.1177/106689690401200412 |
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We also correlated histologic subtype with sex, age, MG, and survival. Ki-67 and p53 labeling indices (LIs) were expressed as a percentage of positive nuclear immunostaining by counting 1,000 epithelial tumor cells. Statistically significant differences were found between Ki-67 LI and survival (p = 0.007), whereas the prognostic implication of p53 could not be demonstrated, although there appeared a trend that patients with tumors of higher LIs had worse survival. Significant correlations were also found between Ki-67 (p < 0.0005) and p53 (p < 0.0005) LIs and histologic subtypes. No correlation was found between these parameters and MG. Histologic subtypes of the WHO classification also correlated with survival (p = 0.01), whereas no correlation was found with sex, age, and MG. In conclusion, our results indicate that the proliferative activity, assessed by Ki-67 LI, and the histologic pattern, according to WHO classification system, seems to represent reliable parameters in the prognosis of thymic epithelial tumors.</description><identifier>ISSN: 1066-8969</identifier><identifier>EISSN: 1940-2465</identifier><identifier>DOI: 10.1177/106689690401200412</identifier><identifier>PMID: 15494865</identifier><identifier>CODEN: IJSPFL</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Adult ; Aged ; Biomarkers, Tumor - metabolism ; Carcinoma, Squamous Cell - classification ; Carcinoma, Squamous Cell - diagnosis ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - mortality ; Cell Nucleus - metabolism ; Cell Nucleus - pathology ; Female ; Humans ; Immunohistochemistry ; Italy - epidemiology ; Ki-67 Antigen - metabolism ; Male ; Middle Aged ; Prognosis ; Survival Rate ; Thymoma - classification ; Thymoma - diagnosis ; Thymoma - metabolism ; Thymoma - mortality ; Thymus Neoplasms - classification ; Thymus Neoplasms - diagnosis ; Thymus Neoplasms - metabolism ; Thymus Neoplasms - mortality ; Tumor Suppressor Protein p53 - metabolism</subject><ispartof>International journal of surgical pathology, 2004-10, Vol.12 (4), p.395-400</ispartof><rights>Copyright Westminster Publications, Inc. 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We also correlated histologic subtype with sex, age, MG, and survival. Ki-67 and p53 labeling indices (LIs) were expressed as a percentage of positive nuclear immunostaining by counting 1,000 epithelial tumor cells. Statistically significant differences were found between Ki-67 LI and survival (p = 0.007), whereas the prognostic implication of p53 could not be demonstrated, although there appeared a trend that patients with tumors of higher LIs had worse survival. Significant correlations were also found between Ki-67 (p < 0.0005) and p53 (p < 0.0005) LIs and histologic subtypes. No correlation was found between these parameters and MG. Histologic subtypes of the WHO classification also correlated with survival (p = 0.01), whereas no correlation was found with sex, age, and MG. In conclusion, our results indicate that the proliferative activity, assessed by Ki-67 LI, and the histologic pattern, according to WHO classification system, seems to represent reliable parameters in the prognosis of thymic epithelial tumors.</description><subject>Adult</subject><subject>Aged</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Carcinoma, Squamous Cell - classification</subject><subject>Carcinoma, Squamous Cell - diagnosis</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Cell Nucleus - metabolism</subject><subject>Cell Nucleus - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Italy - epidemiology</subject><subject>Ki-67 Antigen - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Survival Rate</subject><subject>Thymoma - classification</subject><subject>Thymoma - diagnosis</subject><subject>Thymoma - metabolism</subject><subject>Thymoma - mortality</subject><subject>Thymus Neoplasms - classification</subject><subject>Thymus Neoplasms - diagnosis</subject><subject>Thymus Neoplasms - metabolism</subject><subject>Thymus Neoplasms - mortality</subject><subject>Tumor Suppressor Protein p53 - metabolism</subject><issn>1066-8969</issn><issn>1940-2465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kcFO3DAURa2KqlDaH-gCWSy6C9iO48RLNJoyqEhUYlCXkWO_zBglcbAdYL6A38ajGQkJJFb24rxjv3sR-kXJGaVleU6JEJUUknBCGSGcsi_oiEpOMsZFcZDuCci2xCH6HsI9IYQJRr-hQ1pwyStRHKGXv1eZKPHFEO0KBjx_Hj2EYN2A_3kwVseAbyf_aB9Vh9Vg8Mx5D52KEPCTjWu8sCG6zq2sTlwTNyNgO-C4Bvx_cYNnnUqy1moVt0rX4uV60yd2PqZh6GyyLqfe-fADfW1VF-Dn_jxGd3_my9kiu765vJpdXGc6FyJmudZFk0Na12ihWm2Alm3RFIboXEojKs3KlEfbGFrIikNTccVNzkqW65wXLD9Gv3fe0buHCUKsexs0dJ0awE2hFkLKFFOVwNN34L2b_JD-VjPKt3EzkSC2g7R3IXho69HbXvlNTUm97aj-2FEaOtmbp6YH8zayLyUB5zsgqBW8PfuJ8hXHVpn8</recordid><startdate>200410</startdate><enddate>200410</enddate><creator>Comin, Camilla E.</creator><creator>Messerini, Luca</creator><creator>Novelli, Luca</creator><creator>Boddi, Vieri</creator><creator>Dini, Sergio</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>200410</creationdate><title>KI-67 Antigen Expression Predicts Survival and Correlates with Histologic Subtype in the WHO Classification of Thymic Epithelial Tumors</title><author>Comin, Camilla E. ; Messerini, Luca ; Novelli, Luca ; Boddi, Vieri ; Dini, Sergio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-3cc5b3e120dc6afcde17f5b5d0c399d68c27904fbd15984eb84a4d32723c34523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Carcinoma, Squamous Cell - classification</topic><topic>Carcinoma, Squamous Cell - diagnosis</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Cell Nucleus - metabolism</topic><topic>Cell Nucleus - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Italy - epidemiology</topic><topic>Ki-67 Antigen - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Survival Rate</topic><topic>Thymoma - classification</topic><topic>Thymoma - diagnosis</topic><topic>Thymoma - metabolism</topic><topic>Thymoma - mortality</topic><topic>Thymus Neoplasms - classification</topic><topic>Thymus Neoplasms - diagnosis</topic><topic>Thymus Neoplasms - metabolism</topic><topic>Thymus Neoplasms - mortality</topic><topic>Tumor Suppressor Protein p53 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Comin, Camilla E.</creatorcontrib><creatorcontrib>Messerini, Luca</creatorcontrib><creatorcontrib>Novelli, Luca</creatorcontrib><creatorcontrib>Boddi, Vieri</creatorcontrib><creatorcontrib>Dini, Sergio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of surgical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Comin, Camilla E.</au><au>Messerini, Luca</au><au>Novelli, Luca</au><au>Boddi, Vieri</au><au>Dini, Sergio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>KI-67 Antigen Expression Predicts Survival and Correlates with Histologic Subtype in the WHO Classification of Thymic Epithelial Tumors</atitle><jtitle>International journal of surgical pathology</jtitle><addtitle>Int J Surg Pathol</addtitle><date>2004-10</date><risdate>2004</risdate><volume>12</volume><issue>4</issue><spage>395</spage><epage>400</epage><pages>395-400</pages><issn>1066-8969</issn><eissn>1940-2465</eissn><coden>IJSPFL</coden><abstract>We performed an immunohistochemical study with monoclonal antibodies to Ki-67 antigen and p53 protein on 45 cases of thymic epithelial tumors classified according to the recent World Health Organization (WHO) classification system to evaluate whether there is correlation between the expression of these markers and prognosis, histologic subtype, and myasthenia gravis (MG). We also correlated histologic subtype with sex, age, MG, and survival. Ki-67 and p53 labeling indices (LIs) were expressed as a percentage of positive nuclear immunostaining by counting 1,000 epithelial tumor cells. Statistically significant differences were found between Ki-67 LI and survival (p = 0.007), whereas the prognostic implication of p53 could not be demonstrated, although there appeared a trend that patients with tumors of higher LIs had worse survival. Significant correlations were also found between Ki-67 (p < 0.0005) and p53 (p < 0.0005) LIs and histologic subtypes. No correlation was found between these parameters and MG. Histologic subtypes of the WHO classification also correlated with survival (p = 0.01), whereas no correlation was found with sex, age, and MG. In conclusion, our results indicate that the proliferative activity, assessed by Ki-67 LI, and the histologic pattern, according to WHO classification system, seems to represent reliable parameters in the prognosis of thymic epithelial tumors.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>15494865</pmid><doi>10.1177/106689690401200412</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Biomarkers, Tumor - metabolism Carcinoma, Squamous Cell - classification Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - mortality Cell Nucleus - metabolism Cell Nucleus - pathology Female Humans Immunohistochemistry Italy - epidemiology Ki-67 Antigen - metabolism Male Middle Aged Prognosis Survival Rate Thymoma - classification Thymoma - diagnosis Thymoma - metabolism Thymoma - mortality Thymus Neoplasms - classification Thymus Neoplasms - diagnosis Thymus Neoplasms - metabolism Thymus Neoplasms - mortality Tumor Suppressor Protein p53 - metabolism |
| title | KI-67 Antigen Expression Predicts Survival and Correlates with Histologic Subtype in the WHO Classification of Thymic Epithelial Tumors |
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