Engineered zinc finger-activating vascular endothelial growth factor transcription factor plasmid DNA induces therapeutic angiogenesis in rabbits with hindlimb ischemia

Therapeutic angiogenesis seeks to promote blood vessel growth to improve tissue perfusion. Vascular endothelial growth factor (VEGF) exists in multiple isoforms. We investigated an engineered zinc finger-containing transcription factor plasmid designed to activate the endogenous VEGF gene (ZFP-VEGF)...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2004-10, Vol.110 (16), p.2467-2475
Hauptverfasser:	Dai, Qunsheng, Huang, Jianhua, Klitzman, Bruce, Dong, Chunming, Goldschmidt-Clermont, Pascal J, March, Keith L, Rokovich, Joseph, Johnstone, Brian, Rebar, Edward J, Spratt, S Kaye, Case, Casey C, Kontos, Christopher D, Annex, Brian H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Viral, Tumor - genetics Apoptosis Binding Sites Capillaries - pathology Cytomegalovirus - genetics DNA - metabolism DNA, Recombinant - genetics Female Femoral Artery - injuries Gene Expression Regulation - genetics Genes, Synthetic Genetic Therapy Genetic Vectors - administration & dosage Genetic Vectors - therapeutic use Hindlimb - blood supply Injections, Intramuscular Ischemia - physiopathology Ischemia - therapy Neovascularization, Physiologic - genetics NF-kappa B - genetics Promoter Regions, Genetic - genetics Protein Engineering Protein Isoforms - biosynthesis Protein Isoforms - genetics Rabbits RNA, Messenger - biosynthesis Simian virus 40 - genetics Transcription Factor RelA Vascular Endothelial Growth Factor A - biosynthesis Vascular Endothelial Growth Factor A - genetics Zinc Fingers - genetics Zinc Fingers - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!