Monitoring of Enoxaparin Level Using Citrated Clotting Time during Percutaneous Coronary Intervention
Objectives: To evaluate the use of citrated clotting time (CCT) during percutaneous coronary intervention (PCI) in both emergent and elective scenarios and using intravenous (IV) or subcutaneous (SC) dosing. Background: Monitoring of enoxaparin during PCI had limitations in the past due to lack of p...
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| Veröffentlicht in: | Journal of interventional cardiology 2004-10, Vol.17 (5), p.307-313 |
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| container_title | Journal of interventional cardiology |
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| creator | DÍEZ, JOSE G. CHEONG, BENJAMIN Y.C. O'MEALLIE, LAWRENCE P. ALT, ECKHARD U. |
| description | Objectives: To evaluate the use of citrated clotting time (CCT) during percutaneous coronary intervention (PCI) in both emergent and elective scenarios and using intravenous (IV) or subcutaneous (SC) dosing.
Background: Monitoring of enoxaparin during PCI had limitations in the past due to lack of point‐of‐care testing. Introduction of the CCT enables the determination of the degree of anticoagulation by enoxaparin.
Methods and Results: An analysis on 51 consecutive patients revealed that after three SC doses (1 mg/kg twice a day) or a single IV bolus (1 mg/kg) of enoxaparin, the CCT was consistently in the therapeutic range of ≥260 seconds (475 ± 105 and 565 ± 151 sec, respectively). Patients who received |
| doi_str_mv | 10.1111/j.1540-8183.2004.04030.x |
| format | Article |
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Background: Monitoring of enoxaparin during PCI had limitations in the past due to lack of point‐of‐care testing. Introduction of the CCT enables the determination of the degree of anticoagulation by enoxaparin.
Methods and Results: An analysis on 51 consecutive patients revealed that after three SC doses (1 mg/kg twice a day) or a single IV bolus (1 mg/kg) of enoxaparin, the CCT was consistently in the therapeutic range of ≥260 seconds (475 ± 105 and 565 ± 151 sec, respectively). Patients who received <3 SC doses of enoxaparin were subtherapeutic for PCI. A supplemental IV bolus of 0.3 mg/kg was found always to raise the CCT to therapeutic level (499 ± 178 sec).
Conclusions: Enoxaparin was found to be effective and safe during PCI with low vascular complication rate (9.3%). Patients who received <3 SC doses of enoxaparin benefit most from using CCT monitoring. IV dosing consistently achieved adequate anticoagulation.</description><identifier>ISSN: 0896-4327</identifier><identifier>EISSN: 1540-8183</identifier><identifier>DOI: 10.1111/j.1540-8183.2004.04030.x</identifier><identifier>PMID: 15491334</identifier><language>eng</language><publisher>350 Main Street , Malden , MA 02148 , USA: Blackwell Science Inc</publisher><subject>Angioplasty, Balloon, Coronary - methods ; Anticoagulants - administration & dosage ; Anticoagulants - blood ; Case-Control Studies ; Coronary Artery Disease - therapy ; Drug Monitoring - methods ; Enoxaparin - administration & dosage ; Enoxaparin - blood ; Female ; Humans ; Injections, Intravenous ; Injections, Subcutaneous ; Male ; Middle Aged ; Retrospective Studies ; Treatment Outcome ; Whole Blood Coagulation Time - methods</subject><ispartof>Journal of interventional cardiology, 2004-10, Vol.17 (5), p.307-313</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3190-4b29d5476e2d779796f99a6bb2f1f6a25bbdaa372da1e2313eeacf50994adce93</citedby><cites>FETCH-LOGICAL-c3190-4b29d5476e2d779796f99a6bb2f1f6a25bbdaa372da1e2313eeacf50994adce93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15491334$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DÍEZ, JOSE G.</creatorcontrib><creatorcontrib>CHEONG, BENJAMIN Y.C.</creatorcontrib><creatorcontrib>O'MEALLIE, LAWRENCE P.</creatorcontrib><creatorcontrib>ALT, ECKHARD U.</creatorcontrib><title>Monitoring of Enoxaparin Level Using Citrated Clotting Time during Percutaneous Coronary Intervention</title><title>Journal of interventional cardiology</title><addtitle>J Interv Cardiol</addtitle><description>Objectives: To evaluate the use of citrated clotting time (CCT) during percutaneous coronary intervention (PCI) in both emergent and elective scenarios and using intravenous (IV) or subcutaneous (SC) dosing.
Background: Monitoring of enoxaparin during PCI had limitations in the past due to lack of point‐of‐care testing. Introduction of the CCT enables the determination of the degree of anticoagulation by enoxaparin.
Methods and Results: An analysis on 51 consecutive patients revealed that after three SC doses (1 mg/kg twice a day) or a single IV bolus (1 mg/kg) of enoxaparin, the CCT was consistently in the therapeutic range of ≥260 seconds (475 ± 105 and 565 ± 151 sec, respectively). Patients who received <3 SC doses of enoxaparin were subtherapeutic for PCI. A supplemental IV bolus of 0.3 mg/kg was found always to raise the CCT to therapeutic level (499 ± 178 sec).
Conclusions: Enoxaparin was found to be effective and safe during PCI with low vascular complication rate (9.3%). Patients who received <3 SC doses of enoxaparin benefit most from using CCT monitoring. IV dosing consistently achieved adequate anticoagulation.</description><subject>Angioplasty, Balloon, Coronary - methods</subject><subject>Anticoagulants - administration & dosage</subject><subject>Anticoagulants - blood</subject><subject>Case-Control Studies</subject><subject>Coronary Artery Disease - therapy</subject><subject>Drug Monitoring - methods</subject><subject>Enoxaparin - administration & dosage</subject><subject>Enoxaparin - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Injections, Intravenous</subject><subject>Injections, Subcutaneous</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><subject>Treatment Outcome</subject><subject>Whole Blood Coagulation Time - methods</subject><issn>0896-4327</issn><issn>1540-8183</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtu2zAQRYmiReI8fqHgqjspfEiiuCnQCk7iwk2KwkmWBCWNCrqy6JBUYv99JctIt-FmyJl7LwcHIUxJTIdztY5pmpAopzmPGSFJTBLCSbz7gGZvg49oRnKZRQln4hSdeb8mhJE0ZSfodBBJynkyQ_DTdiZYZ7o_2DZ43tmd3urhiZfwAi1-8OOkMMHpADUuWhvC2FmZDeC6P_h-gav6oDuwvceFdbbTbo8XXQD3Al0wtrtAnxrderg81nP0cD1fFbfR8v5mUXxbRhWnkkRJyWSdJiIDVgshhcwaKXVWlqyhTaZZWpa11lywWlNgnHIAXTUpkTLRdQWSn6MvU-7W2ecefFAb4yto22k5lWUyzxnLB2E-CStnvXfQqK0zm2FtRYkaEau1GkmqkaQaEasDYrUbrJ-Pf_TlBur_xiPTQfB1EryaFvbvDlY_7hfFeB0CoinA-AC7twDt_qpMcJGqp7sb9Tt_FI9iVajv_B86y5ui</recordid><startdate>200410</startdate><enddate>200410</enddate><creator>DÍEZ, JOSE G.</creator><creator>CHEONG, BENJAMIN Y.C.</creator><creator>O'MEALLIE, LAWRENCE P.</creator><creator>ALT, ECKHARD U.</creator><general>Blackwell Science Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200410</creationdate><title>Monitoring of Enoxaparin Level Using Citrated Clotting Time during Percutaneous Coronary Intervention</title><author>DÍEZ, JOSE G. ; CHEONG, BENJAMIN Y.C. ; O'MEALLIE, LAWRENCE P. ; ALT, ECKHARD U.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3190-4b29d5476e2d779796f99a6bb2f1f6a25bbdaa372da1e2313eeacf50994adce93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Angioplasty, Balloon, Coronary - methods</topic><topic>Anticoagulants - administration & dosage</topic><topic>Anticoagulants - blood</topic><topic>Case-Control Studies</topic><topic>Coronary Artery Disease - therapy</topic><topic>Drug Monitoring - methods</topic><topic>Enoxaparin - administration & dosage</topic><topic>Enoxaparin - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Injections, Intravenous</topic><topic>Injections, Subcutaneous</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Retrospective Studies</topic><topic>Treatment Outcome</topic><topic>Whole Blood Coagulation Time - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DÍEZ, JOSE G.</creatorcontrib><creatorcontrib>CHEONG, BENJAMIN Y.C.</creatorcontrib><creatorcontrib>O'MEALLIE, LAWRENCE P.</creatorcontrib><creatorcontrib>ALT, ECKHARD U.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of interventional cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DÍEZ, JOSE G.</au><au>CHEONG, BENJAMIN Y.C.</au><au>O'MEALLIE, LAWRENCE P.</au><au>ALT, ECKHARD U.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Monitoring of Enoxaparin Level Using Citrated Clotting Time during Percutaneous Coronary Intervention</atitle><jtitle>Journal of interventional cardiology</jtitle><addtitle>J Interv Cardiol</addtitle><date>2004-10</date><risdate>2004</risdate><volume>17</volume><issue>5</issue><spage>307</spage><epage>313</epage><pages>307-313</pages><issn>0896-4327</issn><eissn>1540-8183</eissn><abstract>Objectives: To evaluate the use of citrated clotting time (CCT) during percutaneous coronary intervention (PCI) in both emergent and elective scenarios and using intravenous (IV) or subcutaneous (SC) dosing.
Background: Monitoring of enoxaparin during PCI had limitations in the past due to lack of point‐of‐care testing. Introduction of the CCT enables the determination of the degree of anticoagulation by enoxaparin.
Methods and Results: An analysis on 51 consecutive patients revealed that after three SC doses (1 mg/kg twice a day) or a single IV bolus (1 mg/kg) of enoxaparin, the CCT was consistently in the therapeutic range of ≥260 seconds (475 ± 105 and 565 ± 151 sec, respectively). Patients who received <3 SC doses of enoxaparin were subtherapeutic for PCI. A supplemental IV bolus of 0.3 mg/kg was found always to raise the CCT to therapeutic level (499 ± 178 sec).
Conclusions: Enoxaparin was found to be effective and safe during PCI with low vascular complication rate (9.3%). Patients who received <3 SC doses of enoxaparin benefit most from using CCT monitoring. IV dosing consistently achieved adequate anticoagulation.</abstract><cop>350 Main Street , Malden , MA 02148 , USA</cop><pub>Blackwell Science Inc</pub><pmid>15491334</pmid><doi>10.1111/j.1540-8183.2004.04030.x</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Angioplasty, Balloon, Coronary - methods Anticoagulants - administration & dosage Anticoagulants - blood Case-Control Studies Coronary Artery Disease - therapy Drug Monitoring - methods Enoxaparin - administration & dosage Enoxaparin - blood Female Humans Injections, Intravenous Injections, Subcutaneous Male Middle Aged Retrospective Studies Treatment Outcome Whole Blood Coagulation Time - methods |
| title | Monitoring of Enoxaparin Level Using Citrated Clotting Time during Percutaneous Coronary Intervention |
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