Monitoring of Enoxaparin Level Using Citrated Clotting Time during Percutaneous Coronary Intervention

Objectives: To evaluate the use of citrated clotting time (CCT) during percutaneous coronary intervention (PCI) in both emergent and elective scenarios and using intravenous (IV) or subcutaneous (SC) dosing. Background: Monitoring of enoxaparin during PCI had limitations in the past due to lack of point‐of‐care testing. Introduction of the CCT enables the determination of the degree of anticoagulation by enoxaparin. Methods and Results: An analysis on 51 consecutive patients revealed that after three SC doses (1 mg/kg twice a day) or a single IV bolus (1 mg/kg) of enoxaparin, the CCT was consistently in the therapeutic range of ≥260 seconds (475 ± 105 and 565 ± 151 sec, respectively). Patients who received