Glycosidic Torsional Motions in a Bicelle-associated Disaccharide from Residual Dipolar Couplings
An analysis of torsional motions about glycosidic bonds in a disaccharide is undertaken using residual dipolar coupling measurements and selective immobilization of the reducing end sugar to provide a suitable motional reference. The immobilization is accomplished by using the short chain of an alky...
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| Veröffentlicht in: | Journal of the American Chemical Society 2004-10, Vol.126 (42), p.13636-13638 |
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| container_end_page | 13638 |
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| container_issue | 42 |
| container_start_page | 13636 |
| container_title | Journal of the American Chemical Society |
| container_volume | 126 |
| creator | Yi, Xiaobing Venot, André Glushka, John Prestegard, James H |
| description | An analysis of torsional motions about glycosidic bonds in a disaccharide is undertaken using residual dipolar coupling measurements and selective immobilization of the reducing end sugar to provide a suitable motional reference. The immobilization is accomplished by using the short chain of an alkyl glycoside to anchor the disaccharide to a bilayer medium aligned in magnetic field. Motions about the β-(1−4) linkage of the n-butyl-4-O-β−d-galactopyranosyl-α−d-mannopyranoside are shown to be substantial (±40°) and in good agreement with predictions of a fully solvated molecular dynamics simulation. |
| doi_str_mv | 10.1021/ja045697t |
| format | Article |
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The immobilization is accomplished by using the short chain of an alkyl glycoside to anchor the disaccharide to a bilayer medium aligned in magnetic field. Motions about the β-(1−4) linkage of the n-butyl-4-O-β−d-galactopyranosyl-α−d-mannopyranoside are shown to be substantial (±40°) and in good agreement with predictions of a fully solvated molecular dynamics simulation.</description><identifier>ISSN: 0002-7863</identifier><identifier>EISSN: 1520-5126</identifier><identifier>DOI: 10.1021/ja045697t</identifier><identifier>PMID: 15493919</identifier><identifier>CODEN: JACSAT</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Biological and medical sciences ; Carbohydrate Conformation ; Disaccharides - chemistry ; Fundamental and applied biological sciences. 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Am. Chem. Soc</addtitle><description>An analysis of torsional motions about glycosidic bonds in a disaccharide is undertaken using residual dipolar coupling measurements and selective immobilization of the reducing end sugar to provide a suitable motional reference. The immobilization is accomplished by using the short chain of an alkyl glycoside to anchor the disaccharide to a bilayer medium aligned in magnetic field. Motions about the β-(1−4) linkage of the n-butyl-4-O-β−d-galactopyranosyl-α−d-mannopyranoside are shown to be substantial (±40°) and in good agreement with predictions of a fully solvated molecular dynamics simulation.</description><subject>Biological and medical sciences</subject><subject>Carbohydrate Conformation</subject><subject>Disaccharides - chemistry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Galactose - chemistry</subject><subject>Glycosides - chemistry</subject><subject>Intermolecular dynamics</subject><subject>Intermolecular phenomena</subject><subject>Mannose - chemistry</subject><subject>Models, Molecular</subject><subject>Molecular biophysics</subject><subject>Thermodynamics</subject><issn>0002-7863</issn><issn>1520-5126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkU9v1DAQxS0EokvhwBdAvoDEIa3tJP5zpFtaKpWCylKO1sR2wEs2XjyJRL89rnbVvXCaGc1vnp7eEPKasxPOBD9dA2taadT0hCx4K1jVciGfkgVjTFRKy_qIvEBcl7ERmj8nR7xtTG24WRC4HO5dwuijo6uUMaYRBvo5TaVBGkcK9Cy6MAyhAsTkIkzB0_OI4NwvyNEH2ue0obehaMzl9Dxu0wCZLtO8HeL4E1-SZz0MGF7t6zH5fvFxtfxUXX-5vFp-uK6gVmaq2iB0Zxqlai5VKwXTXpjAOyF0U1ybXjbeyNpLIULPpOq87FwjoWE6MN_6-pi82-luc_ozB5zsJuKDcxhDmtFKabQyXBTw_Q50OSHm0NttjhvI95Yz-5CnfcyzsG_2onO3Cf5A7gMswNs9AOhg6DOMLuKBk4JrLVjhqh0XcQp_H_eQf1upatXa1ddv9s7UP-4ubm7t2UEXHNp1mnN5C_7H4D96LZf9</recordid><startdate>20041027</startdate><enddate>20041027</enddate><creator>Yi, Xiaobing</creator><creator>Venot, André</creator><creator>Glushka, John</creator><creator>Prestegard, James H</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20041027</creationdate><title>Glycosidic Torsional Motions in a Bicelle-associated Disaccharide from Residual Dipolar Couplings</title><author>Yi, Xiaobing ; Venot, André ; Glushka, John ; Prestegard, James H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a379t-5e28b9477316756208d29e1b22844289f64d963d622ef067bd6bc46a408e0d5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Biological and medical sciences</topic><topic>Carbohydrate Conformation</topic><topic>Disaccharides - chemistry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Galactose - chemistry</topic><topic>Glycosides - chemistry</topic><topic>Intermolecular dynamics</topic><topic>Intermolecular phenomena</topic><topic>Mannose - chemistry</topic><topic>Models, Molecular</topic><topic>Molecular biophysics</topic><topic>Thermodynamics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yi, Xiaobing</creatorcontrib><creatorcontrib>Venot, André</creatorcontrib><creatorcontrib>Glushka, John</creatorcontrib><creatorcontrib>Prestegard, James H</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Chemical Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yi, Xiaobing</au><au>Venot, André</au><au>Glushka, John</au><au>Prestegard, James H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glycosidic Torsional Motions in a Bicelle-associated Disaccharide from Residual Dipolar Couplings</atitle><jtitle>Journal of the American Chemical Society</jtitle><addtitle>J. Am. Chem. Soc</addtitle><date>2004-10-27</date><risdate>2004</risdate><volume>126</volume><issue>42</issue><spage>13636</spage><epage>13638</epage><pages>13636-13638</pages><issn>0002-7863</issn><eissn>1520-5126</eissn><coden>JACSAT</coden><abstract>An analysis of torsional motions about glycosidic bonds in a disaccharide is undertaken using residual dipolar coupling measurements and selective immobilization of the reducing end sugar to provide a suitable motional reference. The immobilization is accomplished by using the short chain of an alkyl glycoside to anchor the disaccharide to a bilayer medium aligned in magnetic field. 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| ispartof | Journal of the American Chemical Society, 2004-10, Vol.126 (42), p.13636-13638 |
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| language | eng |
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| source | MEDLINE; ACS Publications |
| subjects | Biological and medical sciences Carbohydrate Conformation Disaccharides - chemistry Fundamental and applied biological sciences. Psychology Galactose - chemistry Glycosides - chemistry Intermolecular dynamics Intermolecular phenomena Mannose - chemistry Models, Molecular Molecular biophysics Thermodynamics |
| title | Glycosidic Torsional Motions in a Bicelle-associated Disaccharide from Residual Dipolar Couplings |
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