Effects of ramelteon (TAK-375) on nocturnal sleep in freely moving monkeys

We investigated the effects of ( S)- N-[2-(1,6,7,8-tetrahydro-2 H-indeno-[5,4]furan-8-yl)ethyl]propionamide (ramelteon, TAK-375), a novel MT 1/MT 2 receptor agonist, on nocturnal sleep in freely moving monkeys and compared these results with those of melatonin and zolpidem. Treatment with ramelteon...

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Veröffentlicht in:	Brain research 2004-11, Vol.1027 (1), p.59-66
Hauptverfasser:	Yukuhiro, Nobuhito, Kimura, Hiroyuki, Nishikawa, Hisao, Ohkawa, Shigenori, Yoshikubo, Shin-ichi, Miyamoto, Masaomi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - pharmacology Animals Biological and medical sciences Dose-Response Relationship, Drug EEG Electroencephalography - drug effects Female Fundamental and applied biological sciences. Psychology Hypnotics and Sedatives - pharmacology Indenes - pharmacology Macaca fascicularis Melatonin Melatonin - pharmacology Monkey Polysomnography - drug effects Pyridines - pharmacology Ramelteon (TAK-375) Reaction Time - drug effects Receptors, Melatonin - agonists Sleep Sleep - drug effects Sleep. Vigilance Time Factors Vertebrates: nervous system and sense organs Wakefulness - drug effects
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